{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:02Z","timestamp":1787070722040,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 5-year-old boy presented with gradually progressive painful proptosis of the left eye for 5 months. He had an incidental testicular swelling for which he underwent high inguinal orchidectomy and histopathology showed atypical lymphoid cells. His vision was 6\/6, N6 in the right eye, and no perception of light in the left eye. Left eye examination revealed an inferior dystopia and total ophthalmoplegia with corneal exposure changes. A computerized tomography scan showed an isodense mass molding around the globe. An incision biopsy from the subconjunctival mass showed atypical large lymphocytes on histopathology which on immunohistochemistry confirmed a diagnosis of precursor B-cell lymphoblastic lymphoma (B-LBL). Bone marrow aspiration and biopsy were normal. The patient was started on oral steroids and high-risk acute LBL chemotherapy protocol to which he showed excellent response. Precursor B-LBL is a rare neoplasm of the pediatric and adolescent age group. A total of 22 cases involving the orbit have been reported to date of which 17 belonged to the pediatric age group. Early detection and prompt initiation of multiagent chemotherapy have shown good survival rates in these patients.<\/jats:p>","DOI":"10.4103\/ojo.ojo_346_24","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:00:16Z","timestamp":1750748416000},"page":"212-215","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A rare case of precursor B-cell lymphoblastic lymphoma of the orbit in a child"],"prefix":"10.4103","volume":"18","author":[{"given":"Ruhi Girish","family":"Jange","sequence":"first","affiliation":[{"name":"Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirthi","family":"Koka","sequence":"additional","affiliation":[{"name":"Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramanian","family":"Krishnakumar","sequence":"additional","affiliation":[{"name":"Larson and Toubro Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaarani","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius Xavier","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipasha","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"R1-20250628","first-page":"1477","article-title":"Orbital precursor B-lymphoblastic lymphoma involving the extraocular muscles in a 56-year-old male and a review of the literature","volume":"17","author":"Ejstrup","year":"2019","journal-title":"Oncol Lett"},{"key":"R2-20250628","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/00000478-200011000-00003","article-title":"Precursor B-cell lymphoblastic lymphoma: A predominantly extranodal tumor with low propensity for leukemic involvement","volume":"24","author":"Lin","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R3-20250628","doi-asserted-by":"crossref","first-page":"e000483","DOI":"10.1136\/bmjophth-2020-000483","article-title":"Paediatric ocular adnexal lymphoma: A population-based analysis","volume":"5","author":"Moustafa","year":"2020","journal-title":"BMJ Open Ophthalmol"},{"key":"R4-20250628","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1525-1470.2005.22105.x","article-title":"Concurrent mycosis fungoides and precursor B cell lymphoblastic lymphoma in a 6-year-old child","volume":"22","author":"Chou","year":"2005","journal-title":"Pediatr Dermatol"},{"key":"R5-20250628","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-215679","article-title":"Precursor B cell lymphoblastic lymphoma presenting as periorbital swelling","author":"Galway","year":"2016","journal-title":"BMJ Case Rep 2016"},{"key":"R6-20250628","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3892\/mco.2016.1008","article-title":"Primary orbital precursor T-cell lymphoblastic lymphoma: Report of a unique case","volume":"5","author":"Stenman","year":"2016","journal-title":"Mol Clin Oncol"},{"key":"R7-20250628","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1309\/Q5GV-3K00-WAC6-BBUB","article-title":"Precursor B-cell lymphoblastic lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature","volume":"115","author":"Maitra","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"R8-20250628","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/cncr.11615","article-title":"Lymphoblastic lymphoma of childhood and the LSA2-L2 protocol: The 30-year experience at Memorial-Sloan-Kettering Cancer Center","volume":"98","author":"Mora","year":"2003","journal-title":"Cancer"},{"key":"R9-20250628","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1365-2141.2010.08541.x","article-title":"Clinical presentation, evolution, and prognosis of precursor B-cell lymphoblastic lymphoma in trials LMT96, EORTC 58881, and EORTC 58951","volume":"152","author":"Ducassou","year":"2011","journal-title":"Br J Haematol"},{"key":"R10-20250628","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/08880018.2021.2005725","article-title":"Clinical outcomes and prognostic factors in children with B-cell lymphoblastic lymphoma (LBL) treated according to on modified BFM-90 protocol: Experience from a tertiary cancer care center in India","volume":"39","author":"Vijayasekharan","year":"2022","journal-title":"Pediatr Hematol Oncol"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_346_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:35:27Z","timestamp":1787067327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_346_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_346_24","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-10-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}