{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:11Z","timestamp":1787840411237,"version":"build-2784847793"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The COVID-19 pandemic has had a significant public health impact globally, with inoculation now paramount in limiting the spread of the disease. Although the safety and efficacy profiles of COVID-19 vaccines are well documented, it is upon the medical community to be aware of adverse effects to appropriately advise and treat patients. We report the case of a 39-year-old female who was hospitalized with optic neuritis (ON) 1 week after her second dose of the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine. The patient did not have any significant medical history, including personal or familial history of multiple sclerosis or any other demyelinating disease, other than prior COVID-19 infection. She had since made a full recovery and tested negative at the time of hospitalization for ON. Over the course of her admission, the patient\u2019s visual acuity (VA) deteriorated from 20\/400 to no light perception. After methylprednisolone was ineffective, she was started on plasmapheresis (PLEX) therapy which resulted in mild improvement of VA. To our knowledge and after a thorough PubMed literature search, this is the first reported case of isolated ON associated with COVID-19 vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_354_21","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:49:17Z","timestamp":1716558557000},"page":"397-402","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Optic neuritis secondary to the Pfizer-BioNTech-162b2 COVID-19 vaccine managed with plasmapheresis"],"prefix":"10.4103","volume":"15","author":[{"given":"Paras P.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Gelnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-31-20240908","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N Engl J Med"},{"key":"R3-31-20240908","doi-asserted-by":"crossref","first-page":"e932946","DOI":"10.12659\/AJCR.932946","article-title":"A 59-year-old woman with extensive deep vein thrombosis and pulmonary thromboembolism 7 days following a first dose of the pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine","volume":"22","author":"Al-Maqbali","year":"2021","journal-title":"Am J Case Rep"},{"key":"R4-31-20240908","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1001\/jamacardio.2021.3471","article-title":"Association of myocarditis with BNT162b2 messenger RNA COVID-19 vaccine in a case series of children","volume":"6","author":"Dionne","year":"2021","journal-title":"JAMA Cardiol"},{"key":"R5-31-20240908","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/ICO.0000000000002886","article-title":"Acute corneal transplant rejection after severe acute respiratory syndrome coronavirus 2 mRNA-1273 vaccination","volume":"41","author":"Yu","year":"2022","journal-title":"Cornea"},{"key":"R6-31-20240908","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.survophthal.2021.04.001","article-title":"Ocular adverse events following vaccination: Overview and update","volume":"67","author":"Cheng","year":"2022","journal-title":"Surv Ophthalmol"},{"key":"R7-31-20240908","first-page":"749","article-title":"A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adverse Event Reporting System (VAERS) database and literature review","volume":"22","author":"Geier","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"R8-31-20240908","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1212\/WNL.45.2.244","article-title":"Optic neuritis: A population-based study in Olmsted County, Minnesota","volume":"45","author":"Rodriguez","year":"1995","journal-title":"Neurology"},{"key":"R9-31-20240908","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.autrev.2013.03.012","article-title":"A literature review on optic neuritis following vaccination against virus infections","volume":"12","author":"St\u00fcbgen","year":"2013","journal-title":"Autoimmun Rev"},{"key":"R10-31-20240908","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1001\/archopht.1972.01000020137004","article-title":"Optic neuritis and multiple sclerosis: An epidemiologic study","volume":"87","author":"Percy","year":"1972","journal-title":"Arch Ophthalmol"},{"key":"R11-31-20240908","doi-asserted-by":"crossref","first-page":"101320","DOI":"10.1016\/j.inat.2021.101320","article-title":"Optic neuritis post-COVID-19 infection. A case report with meta-analysis","volume":"26","author":"Azab","year":"2021","journal-title":"Interdiscip Neurosurg"},{"key":"R12-31-20240908","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/09273948.2020.1792512","article-title":"Panuveitis and optic neuritis as a possible initial presentation of the novel coronavirus disease 2019 (COVID-19)","volume":"28","author":"Benito-Pascual","year":"2020","journal-title":"Ocul Immunol Inflamm"},{"key":"R13-31-20240908","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/WNO.0000000000001049","article-title":"Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis and myelitis in COVID-19","volume":"40","author":"Zhou","year":"2020","journal-title":"J Neuroophthalmol"},{"key":"R14-31-20240908","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/jamaophthalmol.2020.5695","article-title":"Coronavirus disease 2019-associated ocular neuropathy with panuveitis: A case report","volume":"139","author":"Fran\u00e7ois","year":"2021","journal-title":"JAMA Ophthalmol"},{"key":"R15-31-20240908","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1080\/02713683.2021.1874027","article-title":"COVID-2019 associated with acquired monocular blindness","volume":"46","author":"Liu","year":"2021","journal-title":"Curr Eye Res"},{"key":"R16-31-20240908","doi-asserted-by":"crossref","first-page":"2324709620976018","DOI":"10.1177\/2324709620976018","article-title":"COVID-19-induced acute bilateral optic neuritis","volume":"8","author":"Sawalha","year":"2020","journal-title":"J Investig Med High Impact Case Rep"},{"key":"R17-31-20240908","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1515\/cclm-2021-0339","article-title":"Comprehensive assessment of humoral response after Pfizer BNT162b2 mRNA Covid-19 vaccination: A three-case series","volume":"59","author":"Danese","year":"2021","journal-title":"Clin Chem Lab Med"},{"key":"R18-31-20240908","first-page":"e17961","article-title":"Neuromyelitis optica in a healthy female after severe acute respiratory syndrome coronavirus 2 mRNA-1273 vaccine","volume":"13","author":"Fujikawa","year":"2021","journal-title":"Cureus"},{"key":"R19-31-20240908","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1080\/09273948.2021.1961815","article-title":"Acute thyroiditis and bilateral optic neuritis following SARS-CoV-2 vaccination with CoronaVac: A case report","volume":"29","author":"Leber","year":"2021","journal-title":"Ocul Immunol Inflamm"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_354_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:20Z","timestamp":1787836940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_354_21"}},"subtitle":["A case report and review"],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_354_21","relation":{},"ISSN":["0974-620X"],"issn-type":[{"value":"0974-620X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}