{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:34Z","timestamp":1787840614083,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rising use of biologicals, especially the anti-tumor necrosis factor \u03b1 inhibitors (anti-TNF-\u03b1 inhibitors) such as adalimumab, certolizumab pegol, etanercept, and infliximab in cases of recalcitrant uveitis with systemic associations have proved to be an effective treatment of choice. However, it also carries an additional risk of developing infections like tuberculosis in an endemic country like India. We present an interesting case of a young male with a history of chronic juvenile idiopathic arthritis treated with adalimumab. He eventually went on to develop ascites, which were presumed to be tubercular in etiology, and hence, an immediate cessation of the biologic was required. The case highlights the known complications of adalimumab and also emphasizes the need for close monitoring of patients on adalimumab.<\/jats:p>","DOI":"10.4103\/ojo.ojo_42_24","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:01:31Z","timestamp":1761670891000},"page":"389-392","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Presumed abdominal tuberculosis in a patient of recalcitrant Juvenile Idiopathic Arthritis associated uveitis treated with Adalimumab"],"prefix":"10.4103","volume":"18","author":[{"given":"Saloni","family":"Desai","sequence":"first","affiliation":[{"name":"Department of Uveitis and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotirmay","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Uveitis and Ocular Pathology, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"R1-20251030","first-page":"623","article-title":"Biologic agents and tuberculosis","volume":"2017","author":"Dobler","journal-title":"Tuberculosis and Nontuberculous Mycobacterial Infections"},{"key":"R2-20251030","doi-asserted-by":"crossref","first-page":"5792937","DOI":"10.1155\/2020\/5792937","article-title":"Utility of Ascitic Fluid Adenosine Deaminase Levels in the Diagnosis of Tuberculous Peritonitis in General Medical Practice","volume":"2020","author":"Kumabe","year":"2020","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"R3-20251030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/0974-2727.187927","article-title":"Performance of Xpert MTB\/RIF on ascitic fluid samples for detection of abdominal tuberculosis","volume":"9","author":"Rufai","year":"2017","journal-title":"J Lab Physicians"},{"key":"R4-20251030","first-page":"762","article-title":"Extra-pulmonary reactivation of latent tuberculosis after initiation of anti-tumour necrosis factor therapy for inflammatory bowel disease-are current screening strategies adequate?","volume":"11","author":"Tranah","year":"2017","journal-title":"J Crohns Colitis"},{"key":"R5-20251030","doi-asserted-by":"crossref","first-page":"bcr2018224459","DOI":"10.1136\/bcr-2018-224459","article-title":"Miliary tuberculosis and herpes pharyngitis after a trip to a developing country:Dangers of biologics","volume":"2018","author":"Patel","year":"2018","journal-title":"BMJ Case Rep"},{"key":"R6-20251030","doi-asserted-by":"crossref","first-page":"bcr1220115395","DOI":"10.1136\/bcr.12.2011.5395","article-title":"Coincident intra-abdominal presentation of lymphoma and tuberculosis after long-term iatrogenic immunosuppression","volume":"2012","author":"Negi","year":"2012","journal-title":"BMJ Case Rep"},{"key":"R7-20251030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5144\/0256-4947.2021.285","article-title":"The risk of tuberculosis infection in 410 Saudi patients receiving adalimumab therapy","volume":"41","author":"Al-Sohaim","year":"2021","journal-title":"Ann Saudi Med"},{"key":"R8-20251030","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cyto.2016.08.014","article-title":"Molecular mechanisms of action of anti-TNF-? agents \u2013Comparison among therapeutic TNF-? antagonists","volume":"101","author":"Mitoma","year":"2018","journal-title":"Cytokine"},{"key":"R9-20251030","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1146\/annurev.immunol.21.120601.141110","article-title":"T cell anergy","volume":"21","author":"Schwartz","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"R10-20251030","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/s12879-019-4034-z","article-title":"Evaluation of treatment response in extrapulmonary tuberculosis in a low-resource setting","volume":"19","author":"J\u00f8rstad","year":"2019","journal-title":"BMC Infect Dis"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_42_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:55Z","timestamp":1787837155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_42_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_42_24","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2024-02-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}