{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:17Z","timestamp":1787775677615,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder primarily affecting young males, characterized by progressive vision loss due to retinal ganglion cell degeneration. LHON is typically associated with specific mitochondrial mutations with potential triggers such as environmental factors and, more recently, postvaccination complications. We present a case of a 35-year-old male who experienced LHON onset 3 weeks following administration of the AstraZeneca Coronavirus disease 2019 vaccine. Despite lacking traditional risk factors, genetic testing confirmed the presence of the mitochondrial genome coding for the NADH-ubiquinone oxidoreductase chain four (MT-ND4) m.11778G &gt;A mutation. The patient\u2019s presentation contributed to a delay in diagnosing LHON as demyelinating disease optic neuritis, and after excluding all the possible causes, the diagnosis of postvaccination LHON was considered. Continued vigilance and awareness among healthcare providers are essential for prompt identification and management of LHON in postvaccination contexts.<\/jats:p>","DOI":"10.4103\/ojo.ojo_431_24","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:00:11Z","timestamp":1772218811000},"page":"137-139","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Leber hereditary optic neuropathy triggered by the AstraZeneca coronavirus disease 2019 vaccination"],"prefix":"10.4103","volume":"19","author":[{"given":"Anan A.","family":"Aljawi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nooran Osama","family":"Badeeb","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ophthalmology Division, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia"},{"name":"Department of Ophthalmology, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"R1-20260302","first-page":"1165","article-title":"Leber hereditary optic neuropathy: Current perspectives","volume":"9","author":"Meyerson","year":"2015","journal-title":"Clin Ophthalmol"},{"key":"R2-20260302","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.yaoo.2023.03.004","article-title":"Neuro-ophthalmic complications of COVID-19 infection and vaccination","volume":"8","author":"Alotaibi","year":"2023","journal-title":"Adv Ophthalmol Optom"},{"key":"R3-20260302","doi-asserted-by":"crossref","first-page":"e528","DOI":"10.1097\/WNO.0000000000002037","article-title":"COVID-19 disease: A trigger for leber hereditary optic neuropathy (LHON)","volume":"44","author":"Benbunan-Ferreiro","year":"2024","journal-title":"J Neuroophthalmol"},{"key":"R4-20260302","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1097\/WNO.0000000000001790","article-title":"Leber hereditary optic neuropathy 3 weeks after COVID-19 vaccination","volume":"44","author":"Gonz\u00e1lez-Mart\u00edn-Moro","year":"2024","journal-title":"J Neuroophthalmol"},{"key":"R5-20260302","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1097\/WNO.0000000000001665","article-title":"A case of Leber hereditary optic neuropathy triggered by Pfizer-BioNTech vaccine: evidence of pathogenesis of a novel mutation","volume":"44","author":"Rizk","year":"2024","journal-title":"J Neuroophthalmol."}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_431_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:38:10Z","timestamp":1787773090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_431_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_431_24","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-12-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}