{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:43Z","timestamp":1787772463077,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>An 18-year-old male diagnosed with acrodermatitis enteropathica (AE) since early childhood presented with worsening of dermatitis along with photophobia and watering in both eyes. Systemic evaluation by dermatology and gastroenterology specialists confirmed a diagnosis of acute exacerbation of AE, and oral zinc supplements were initiated. A best-corrected visual acuity of 20\/20 was documented in both eyes. Slit-lamp examination revealed bilateral subepithelial corneal opacities in a radial fan-like pattern extending from the superior limbus toward the center. A whorled appearance of fluorescein staining and small epithelial erosions was noted in both eyes. Ocular involvements in AE such as blepharitis, cataracts, and radial corneal opacities have been reported previously. We report a new association of AE with limbal stem cell deficiency with its classical features of linear subepithelial corneal opacities with a whorling uptake of fluorescein stain and corneal erosions.<\/jats:p>","DOI":"10.4103\/ojo.ojo_46_22","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:56:24Z","timestamp":1716558984000},"page":"326-328","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A novel case of limbal stem cell deficiency in a patient with acrodermatitis enteropathica"],"prefix":"10.4103","volume":"16","author":[{"given":"Gayatri","family":"Sundareswaran","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anandan","family":"Sankarasubramaniam","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"R1-20240908","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ng913","article-title":"Identification of SLC39A4, a gene involved in acrodermatitis enteropathica","volume":"31","author":"K\u00fcry","year":"2002","journal-title":"Nat Genet"},{"key":"R2-20240908","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1365-2133.1979.tb03567.x","article-title":"Acrodermatitis enteropathica","volume":"100","author":"Danbolt","year":"1979","journal-title":"Br J Dermatol"},{"key":"R3-20240908","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1755-3768.1962.tb07832.x","article-title":"Eye symptoms in Acromdermatitis enteropathica. 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