{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:31:10Z","timestamp":1787761870175,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Bietti crystalline dystrophy is a rare hereditary autosomal recessive disease that causes photoreceptor loss secondary to degeneration of retinal pigment epithelium due to intracellular retinal pigment epithelial crystalline deposits and abnormal lipid metabolism. We aimed to present a case of choroidal neovascular membrane secondary to Bietti crystalline dystrophy diagnosed with multimodal imaging and treated with an intravitreal injection of aflibercept. A single dose of aflibercept injection might be effective due to its higher affinity for vascular endothelial growth factor (VEGF) in comparison with other anti-VEGFs. It might be a treatment alternative that can be considered in the choroidal neovascular membrane due to uncommon etiologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_9_22","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T02:50:51Z","timestamp":1676947851000},"page":"142-144","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Bietti crystalline dystrophy complicated by choroidal neovascularization treated with a single dose of aflibercept"],"prefix":"10.4103","volume":"16","author":[{"given":"Merve","family":"Ozbek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seren","family":"Pehlivanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil Ozgur","family":"Artunay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-32-20240908","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/ICB.0b013e3181780832","article-title":"Bietti crystalline dystrophy with bilateral macular holes","volume":"3","author":"Ji","year":"2009","journal-title":"Retin Cases Brief Rep"},{"key":"R2-32-20240908","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.2147\/OPTH.S185744","article-title":"Current perspectives in Bietti crystalline dystrophy","volume":"13","author":"Garc\u00eda-Garc\u00eda","year":"2019","journal-title":"Clin Ophthalmol"},{"key":"R3-32-20240908","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.4103\/ijo.IJO_39_18","article-title":"Multimodal imaging of Bietti's crystalline dystrophy","volume":"66","author":"Kumar","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"R4-32-20240908","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10792-010-9406-8","article-title":"Bietti crystalline dystrophy and choroidal neovascularisation","volume":"31","author":"Gupta","year":"2011","journal-title":"Int Ophthalmol"},{"key":"R5-32-20240908","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3341\/kjo.2014.28.2.189","article-title":"Acetazolamide for cystoid macular oedema in Bietti crystalline retinal dystrophy","volume":"28","author":"Broadhead","year":"2014","journal-title":"Korean J Ophthalmol"},{"key":"R6-32-20240908","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/0301-4738.95873","article-title":"Ranibizumab for choroidal neovascular membrane in a rare case of Bietti's crystalline dystrophy: A case report","volume":"60","author":"Nachiappan","year":"2012","journal-title":"Indian J Ophthalmol"},{"key":"R7-32-20240908","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/13816810.2015.1126616","article-title":"Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization","volume":"37","author":"Fuerst","year":"2016","journal-title":"Ophthalmic Genet"},{"key":"R8-32-20240908","first-page":"1970","article-title":"Molecular screening of the CYP4V2 gene in Bietti crystalline dystrophy that is associated with choroidal neovascularization","volume":"17","author":"Mamatha","year":"2011","journal-title":"Mol Vis"},{"key":"R9-32-20240908","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12886-020-01545-3","article-title":"Multimodal imaging features and genetic findings in Bietti crystalline dystrophy","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"R10-32-20240908","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1167\/iovs.61.13.22","article-title":"Preclinical efficacy and safety of VEGF-grab, a novel anti-VEGF drug, and its comparison to aflibercept","volume":"61","author":"Hong","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_9_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:06:44Z","timestamp":1787760404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_9_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_9_22","relation":{},"ISSN":["0974-620X"],"issn-type":[{"value":"0974-620X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}