{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:07:02Z","timestamp":1787170022129,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Bilastine is a novel second-generation antihistaminic. Very few studies in Indian population have compared the safety and efficacy of bilastine with other second-generation antihistaminic like cetirizine. Hence, the present study was planned.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was a randomized, open-label comparative parallel group study conducted on 70 patients of chronic spontaneous urticaria (CSU). Patients either received cetirizine 10 mg or bilastine 20 mg once daily for 6 weeks. The primary endpoint was to find out the difference in the mean total symptom score (MTSS) at baseline and 6 weeks. The secondary endpoint was to find out changes in the scale of the number of wheals, change in pruritus scale, scale for size of wheal, change for interference of wheals with sleep, change in visual analog scale (VAS) for sedation, change in scale for intensity of erythema, and change in Scale for Extent of Skin Area Involvement (SESI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Bilastine and cetirizine offer a significant reduction in MTSS, mean number of wheals, and mean pruritus scale at baseline to 1, 3, and 6 weeks. The mean difference in MTSS was significantly more in bilastine. Cetirizine showed a significant increase in VAS score for sedation as compared to bilastine. Both the drugs were well tolerated and safe. Adverse events like headache, gastric irritation, dryness of mouth, and sedation were more reported in cetirizine group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bilastine was more efficacious than cetirizine in patients of CSU and the efficacy was seen earlier at 1 week, which was not seen in the cetirizine group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/picr.picr_28_23","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:40:43Z","timestamp":1696581643000},"page":"180-186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Comparative study of efficacy and safety of cetirizine and bilastine in patients of chronic spontaneous urticaria: Open-label, randomized, parallel-group study"],"prefix":"10.4103","volume":"14","author":[{"given":"Vishakha V.","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrunalini Vinay","family":"Kalikar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh Ishwardas","family":"Mukhi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Government Medical College, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil Bhagwan","family":"Giradkar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Sontakke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Shri Vasantrao Naik Government Medical College, Yavatmal, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/ijd.IJD_308_17","article-title":"Consensus statement for the diagnosis and treatment of urticaria:A 2017 update","volume":"63","author":"Godse","year":"2018","journal-title":"Indian J Dermatol"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.dsi.2017.09.002","article-title":"Aktan Sebnem, Turkish dermatologists'approach for chronic spontaneous urticaria:A questionnaire based study","volume":"36","author":"Kocat\u00fcrk","year":"2018","journal-title":"Dermatol Sin"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1111\/j.1398-9995.2009.02177.x","article-title":"The definition and diagnostic testing of physical and cholinergic urticarias \u2013EAACI\/GA2LEN\/EDF\/UNEV consensus panel recommendations","volume":"64","author":"Magerl","year":"2009","journal-title":"Allergy"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1398-9995.2010.02496.x","article-title":"Unmet clinical needs in chronic spontaneous urticaria. A GA\u00b2LEN task force report","volume":"66","author":"Maurer","year":"2011","journal-title":"Allergy"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5415\/apallergy.2016.6.1.56","article-title":"Role of bilastine in the management of allergic rhinitis and urticaria:An Asia-pacific consensus statement","volume":"6","author":"M\u00f6sges","year":"2016","journal-title":"Asia Pac Allergy"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1398-9995.2009.02179.x","article-title":"EAACI\/GA(2)LEN\/EDF\/WAO guideline:Definition, classification and diagnosis of urticaria","volume":"64","author":"Zuberbier","year":"2009","journal-title":"Allergy"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/ijdd.ijdd_12_18","article-title":"Bilastine:A novel antihistamine","volume":"4","author":"Gandhi","year":"2018","journal-title":"Indian J Drugs Dermatol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1398-9995.2009.02217.x","article-title":"Comparison of the efficacy and safety of bilastine 20 mg versus levocetirizine 5 mg for the treatment of chronic idiopathic urticaria:A Multi-Centre, double-blind, randomized, placebo-controlled study","volume":"65","author":"Zuberbier","year":"2010","journal-title":"Allergy"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/ijd.12250","article-title":"Clinical effectiveness and safety of cetirizine versus rupatadine in chronic spontaneous urticaria:A randomized, double-blind, 6-week trial","volume":"53","author":"Dakhale","year":"2014","journal-title":"Int J Dermatol"},{"key":"R11-20240829","first-page":"318","article-title":"Comparative efficacy and safety of loratadine and cetirizine in patients with chronic idiopathic urticaria","volume":"14","author":"Patel","year":"1997","journal-title":"Adv Ther"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12948-015-0008-x","article-title":"Bilastine:New insight into antihistamine treatment","volume":"13","author":"Ridolo","year":"2015","journal-title":"Clin Mol Allergy"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/14740338.2018.1502268","article-title":"Comparative study of the effect of bilastine and cetirizine on cognitive functions at ground level and at an altitude of 4,000 m simulated in hypobaric chamber:A randomized, double-blind, placebo-controlled, cross-over study","volume":"17","author":"Rem\u00e9nyi","year":"2018","journal-title":"Expert Opin Drug Saf"},{"issue":"Suppl 3","key":"R14-20240829","first-page":"9","article-title":"Bilastine and the central nervous system","volume":"21","author":"Montoro","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"R17-20240829","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/jdv.14305","article-title":"Bilastine:A new H(1) \u2013Antihistamine with an optimal profile for updosing in urticaria","volume":"31","author":"Church","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R18-20240829","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jaci.2020.03.005","article-title":"The role of eosinophils in chronic spontaneous urticaria","volume":"145","author":"Altrichter","year":"2020","journal-title":"J Allergy Clin Immunol"}],"container-title":["Perspectives in Clinical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/picr.picr_28_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:16:49Z","timestamp":1787167009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/picr.picr_28_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,8]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/picr.picr_28_23","relation":{},"ISSN":["2229-3485","2229-5488"],"issn-type":[{"value":"2229-3485","type":"print"},{"value":"2229-5488","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,8]]},"assertion":[{"value":"2023-02-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}