{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:33:26Z","timestamp":1791311606529,"version":"4.3.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Diabetic foot ulcers (DFUs) are a severe diabetes complication, often leading to amputations. Despite medical advancements, no standard treatment exists. Conventional care is insufficient, prompting research into new therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>Phenytoin, an antiepileptic drug, has shown potential in wound healing by stimulating fibroblast proliferation. This study evaluated the efficacy and safety of topical phenytoin cream versus standard care for DFUs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This randomized, open-label trial was conducted at a tertiary hospital in India. Adults with diabetes and full-thickness lower extremity ulcers (Grade IA or II, University of Texas Classification) were randomized 1:1 to receive either topical phenytoin 1% cream or saline dressing daily for 8 weeks. The primary outcome was complete ulcer healing at 8 weeks. Secondary outcomes were healing time, ulcer size reduction, and adverse events. The primary outcome was analysed using the Chi-square test for independence, while secondary outcomes, namely time to wound closure, the percentage reduction in ulcer surface area and incidence of adverse events were analysed using the log-rank test, Mann-Whitney U test and Chi-square test respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 28 participants, two were lost to follow-up. Healing rates were 23% (phenytoin) vs. 53% (saline) (p=0.102). Median healing time was 8 weeks in both groups (p=0.142). Ulcer size reduction was greater with saline (89.19% \u00b1 17.33%) than phenytoin (56.51% \u00b1 46.11%; p=0.037). Adverse events were fewer with phenytoin (p=0.431).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Topical phenytoin was safe but not superior. Larger trials are needed to confirm its role in DFU treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/picr.picr_61_25","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T21:00:09Z","timestamp":1757710809000},"page":"33-38","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of topical phenytoin cream in diabetic foot ulcers: A randomized, open-label, parallel, and proof-of-concept study"],"prefix":"10.4103","volume":"17","author":[{"given":"A.","family":"Vinayak","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeet K.","family":"Bhilwade","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarsh P.","family":"Gajjar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monty U.","family":"Khajanchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Seth G. S. 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