{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:09:52Z","timestamp":1789002592508,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>Colitis is a type of inflammatory bowel disease (IBD) with an unknown and complex etiology. Lacosamide is a known antiepileptic drug for which anti-inflammatory effects have been reported. This study investigates the ameliorative effects of lacosamide on acetic acid-induced colitis in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach:<\/jats:title>\n                    <jats:p>Male Wistar rats were divided into different interventional groups, including normal and control colitis groups (normal saline, 5 mL\/kg), two colitis groups (dexamethasone, 1 mg\/kg) and mesalazine (100 mg\/kg), four colitis groups received oral lacosamide (10, 20, or 40 mg\/kg), or lacosamide enema (10 mg\/kg). The treatments were conducted for five days following disease induction by acetic acid (3.5%, 2 mL). Colitis indices in tissue samples, as well as biochemical factors such as myeloperoxidase (MPO), malondialdehyde (MDA), and ferric reducing antioxidant power (FRAP), were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings\/Results:<\/jats:title>\n                    <jats:p>\n                      The trend of body weight drop was stopped by using lacosamide. Colon weight as well as ulcer index significantly decreased in the groups that received lacosamide (10-40 mg\/kg\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      oral or rectal) compared to the control group. Histological findings showed that lacosamide (10 and 20 mg\/kg\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      oral and enema) reduced inflammation markers and tissue damage while causing tissue regeneration. Levels of MDA and MPO significantly decreased while FRAP increased in lacosamide (10 and 20 mg\/kg) groups, both oral and\n                      <jats:italic toggle=\"yes\">via<\/jats:italic>\n                      enema.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and implications:<\/jats:title>\n                    <jats:p>Findings highlight the potential of lacosamide as an effective treatment in reducing inflammation and promoting ulcer healing. However, further studies are needed to elucidate the precise mechanisms of lacosamide's anti-inflammatory effects and to confirm these results in human disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/rps.rps_24_25","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T15:00:20Z","timestamp":1766847620000},"page":"36-46","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the anti-ulcerative effects of lacosamide in a rat model of acetic acid-induced colitis"],"prefix":"10.4103","volume":"21","author":[{"given":"Mohsen","family":"Minaiyan","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan, 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