{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:57:45Z","timestamp":1792241865390,"version":"4.4.0"},"reference-count":54,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>Spinal cord injury (SCI) causes motor and cognitive impairments, with secondary hippocampal damage contributing to memory deficits. This study examined the effects of neural stem cell (NSC)-laden polyurethane\/functionalized multiwalled carbon nanotube (PU\/f-MWCNT) scaffolds coated with liposomal hesperidin (Hsd@lip) on hippocampal synaptic integrity, neuroinflammation, and memory in a rat model of dorsal hemisection SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach:<\/jats:title>\n                    <jats:p>Electrospun PU\/f-MWCNT scaffolds were prepared and loaded with NSCs, Hsd@lip, or both. Wistar rats (n = 15\/group) were assigned to untreated SCI, scaffold+Hsd@lip (PCH), scaffold+NSC (PCN), or scaffold+NSC+Hsd@lip (PCHN). Four weeks post-implantation, hippocampal synaptic plasticity, oxidative stress, neuronal survival, and memory performance were evaluated using electrophysiology, biochemical assays, histology, and behavioral tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings\/Results:<\/jats:title>\n                    <jats:p>The scaffolds were uniform, bead-free fibers with an average diameter of 174.7 \u00b1 63.5 nm. Hsd@lip coating formed a thin, non-aggregated layer that maintained scaffold porosity. Cell seeding demonstrated good NSC adhesion and spreading, supporting the scaffold\u2019s biocompatibility. Compared to the SCI group, animals treated with PCHN exhibited a significant reduction in MDA levels and decreased AChE activity, and increased thiol content. Doublecortin expression markedly increased, while NF-\u03baB levels and dark neuron counts significantly reduced. Furthermore, cognitive function improved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and implications:<\/jats:title>\n                    <jats:p>These findings highlight the potential of NSC-laden PU\/f-MWCNT scaffolds coated with Hsd@lip to mitigate hippocampal damage, restore synaptic integrity, and improve cognitive function following SCI. This multimodal approach offers a promising therapeutic strategy for addressing the cognitive sequelae of SCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/rps.rps_39_25","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:00:45Z","timestamp":1760976045000},"page":"760-776","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Hippocampal synaptic markers and cognitive recovery in spinal cord injury: the therapeutic potential of neural stem cell-laden carbon nanotube-based fiber scaffolds with liposomal hesperidin"],"prefix":"10.4103","volume":"20","author":[{"given":"Amirhossein Rabiei","family":"Rad","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Tokat Gaziosmanpa\u015fa University, Tokat, 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