{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:57:50Z","timestamp":1781179070386,"version":"3.54.1"},"reference-count":0,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":1361,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>\n Introduction: Plasmablastic lymphoma\n (PBL) is a rare lymphoma associated with\n immunosuppression. It is strongly associated with\n immunosuppression (human immunodeficiency virus\n [HIV]) and often occurs within the oral cavity.\n PBL is also seen in patients receiving\n immunosuppressive therapy; however, despite its\n predisposition for the immunocompromised patients,\n PBL has been diagnosed in immunocompetent\n patients. Aim: This study aims to prognostic\n factors and outcome of PBL in immunocompromised\n and in immunocompetent patients. Materials and\n Methods: We conducted a retrospective study at our\n institute from the year 2008 to 2015. Results: A\n total of 13 patients (8 males and 5 females) with\n PBL were identified. Eight patients (61.5%) had\n extraoral PBL (median age 30.2 years) and 5\n patients (38.5%) had oral PBL (median age 44\n years). Most common extraoral site was\n gastrointestinal tract. Eight (61.5%) out of 13\n patients were HIV positive. More than 50% of\n patients had Ann Arbor Stage III or IV. All the\n cases were CD20 negative and CD138 positive. Seven\n out of 13 patients had Ki-67 more than 80%. Nine\n patients received cyclophosphamide, doxorubicin,\n vincristine, and prednisone chemotherapy. Three\n patients were on best supportive care due to poor\n performance status (PS). One patient received\n intensive chemotherapy with CODOX-M\/IVAC. The\n median overall survival was 9 months in\n HIV-positive patients and 6 months in HIV-negative\n patients. The prognosis was worse in patients with\n Ki-67 of >80%. Statistical Analysis: Survival\n curves were generated using the Kaplan\u2013Meier\n method and analyzed using log-rank test and\n Fisher's t-test. Conclusion: The present study\n confirms that PBL in both HIV-positive and in\n HIV-negative patients has an overall unfavorable\n outcome. The most important prognostic factors are\n stage, ki-67, and the Eastern Cooperative Oncology\n Group PS of the patient at the time of\n presentation.<\/jats:p>","DOI":"10.4103\/sajc.sajc_186_16","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T12:47:03Z","timestamp":1610369223000},"page":"069-071","source":"Crossref","is-referenced-by-count":9,"title":["Plasmablastic lymphoma in immunocompetent\n and in immunocompromised patients: Experience at a\n regional cancer centre in India"],"prefix":"10.25259","volume":"06","author":[{"given":"A.H.","family":"Rudresha","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.C.","family":"Lakshmaiah","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Govind","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Loknatha","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linu Abraham","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.N.","family":"Lokesh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.K.","family":"Rajeev","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,12,22]]},"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/sajc.sajc_186_16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:11:38Z","timestamp":1781176298000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/plasmablastic-lymphoma-in-immunocompetent-and-in-immunocompromised-patients-experience-at-a-regional-cancer-centre-in-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,12,22]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.4103\/sajc.sajc_186_16","relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}