{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:34:35Z","timestamp":1792683275718,"version":"4.5.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context:<\/jats:title>\n                    <jats:p>The use of perioperative antimicrobial prophylaxis has been consistently considered an effective means of reducing the risk of surgical site infections. However, inappropriate use of surgical antibiotic prophylaxis is associated with complications such as reduced treatment efficacy, development of antibiotic resistance, and increased health-care costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim of this study is to investigate the adherence to international\/national guidelines regarding the use of surgical antibiotic prophylaxis in the perioperative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>King Faisal Specialist Hospital and Research Centre (KFSH&amp;RC) a 1589-bed tertiary\/quaternary care and referral hospital based in Riyadh, Saudi Arabia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>A retrospective observational study, in which antibiotic prophylaxis parameters were assessed against recommendations provided by international\/national guidelines in elective\/emergency procedures performed at the general operating suite. Data was obtained from the medical records starting of 174 cases over a period of 2 weeks in May 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Preoperative antibiotic prophylaxis (PAP) was prescribed for 118 (78.7%) patients, 72 (61%) of which were \u201crecommended,\u201d whereas 46 (39%) were \u201cnot recommended.\u201d Of the 72 patients for whom the antibiotics were \u201crecommended\u201d and given, 19 (26.4%) received \u201cinadequate\u201d choice of antibiotics, 50 (69.4%) received a sub-therapeutic dose, 14 (19.4%) had \u201cimproper\u201d timing of the first dose, 11 (15.3%) were given an \u201cinappropriate\u201d second intraoperative dose, and 43 (59.7%) had an unnecessarily extended duration of prophylaxis. The overall compliance to guidelines was achieved in only 23 (15.3%) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A significant gap between current KFSH &amp; RC practice and international\/national guidelines regarding surgical antibiotic prophylaxis usage has been demonstrated which calls for immediate action to ensure effective guideline adoption and implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sja.sja_187_17","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T01:07:11Z","timestamp":1515373631000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["An observational study of perioperative antibiotic-prophylaxis use at a major quaternary care and referral hospital in Saudi Arabia"],"prefix":"10.4103","volume":"12","author":[{"given":"Yasser Younis","family":"A. Tolba","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, King Faisal Specialist Hospital and Research Centre, Egypt"},{"name":"Associate Professor of Anesthesiology, College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia"},{"name":"Senior Lecturer, Department of Anaesthesiology, National Cancer Institute, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Osama","family":"El-Kabbani","sequence":"additional","affiliation":[{"name":"Associate Professor of Anesthesiology, College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NorAldeen Suhail","family":"Al-Kayyali","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, College of Science, King Fahd University of Petroleum and Minerals, Al-Khobar, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2146\/ajhp120568","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"70","author":"Bratzler","year":"2013","journal-title":"Am J Health Syst Pharm"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archsurg.141.11.1109","article-title":"Implementing 1-dose antibiotic prophylaxis for prevention of surgical site infection","volume":"141","author":"Fonseca","year":"2006","journal-title":"Arch Surg"},{"issue":"Suppl 10","key":"R8-20250920","doi-asserted-by":"crossref","first-page":"S879","DOI":"10.1093\/clinids\/13.Supplement_10.S879","article-title":"Cost and benefit of perioperative antimicrobial prophylaxis: Methods for economic analysis","volume":"13","author":"McGowan","year":"1991","journal-title":"Clin Infect Dis"},{"issue":"Suppl 1","key":"R9-20250920","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1086\/591064","article-title":"Strategies to prevent surgical site infections in acute care hospitals","volume":"29","author":"Anderson","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11096-012-9719-y","article-title":"An audit of prophylactic surgical antibiotic use in a Sudanese teaching hospital","volume":"35","author":"Elbur","year":"2013","journal-title":"Int J Clin Pharm"},{"key":"R12-20250920","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1086\/591861","article-title":"NHSN annual update: Antimicrobial-resistant pathogens associated with healthcare-associated infections: Annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007","volume":"29","author":"Hidron","year":"2008","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01437113-201812010-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:52:15Z","timestamp":1787838735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01437113-201812010-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/sja.sja_187_17","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}