{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:28:37Z","timestamp":1787228917907,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intrathecal chemical neurolysis with phenol is a neuroablative technique reserved for cases of refractory cancer pain in which pharmacological strategies and less invasive interventional procedures have failed. We report the case of an 87-year-old man with stage IV prostate cancer and severe perineal pain refractory to strong opioids and adjuvant analgesics, who underwent intrathecal phenol neurolysis as a last-resort intervention. Within 24 hours, the patient experienced a marked improvement in pain control, allowing progressive tapering and eventual discontinuation of systemic opioids. Adequate analgesia was maintained until the patient\u2019s death during the same admission, in the context of disease progression, without recurrence of severe pain. This case illustrates the potential role of intrathecal phenol in carefully selected palliative-care scenarios, where the primary therapeutic objective is relief of suffering and improvement of quality of life in terminal stages of illness.<\/jats:p>","DOI":"10.4103\/sja.sja_47_26","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:01:20Z","timestamp":1782968480000},"page":"713-715","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Intrathecal phenol neurolysis for refractory perineal cancer pain: A case report"],"prefix":"10.4103","volume":"20","author":[{"given":"Enrique Lacoba","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Management, Hospital Cl\u00ednic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles Espin\u00f3s","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Management, Hospital Cl\u00ednic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem Urquijo","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Management, Hospital Cl\u00ednic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi P\u00e9rez","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Management, Hospital Cl\u00ednic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"R1-20260820","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9610(33)91041-7","article-title":"Segmental peridural spinal anesthesia: A new method of conduction anesthesia","volume":"20","author":"Dogliotti","year":"1933","journal-title":"Am J Surg"},{"key":"R2-20260820","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/jnnp.73.6.705","article-title":"Managing severe lower limb spasticity in multiple sclerosis: Does intrathecal phenol have a role?","volume":"73","author":"Jarrett","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R3-20260820","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2044.1978.tb08472.x","article-title":"Intrathecal neurolysis","volume":"33","author":"Swerdlow","year":"1978","journal-title":"Anaesthesia"},{"key":"R4-20260820","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1521-6896(03)00016-8","article-title":"Intrathecal neurolytic blocks for the relief of cancer pain","volume":"17","author":"Candido","year":"2003","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"R5-20260820","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.oooo.2024.08.018","article-title":"Adverse effects associated with the irresponsible use of phenol peeling: Literature review","volume":"139","author":"de Oliveira Ciaramicolo","year":"2025","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"R6-20260820","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00401-003-0730-1","article-title":"The effect of combined neurolytic blocking agent 5% phenol-glycerol in rat sciatic nerve","volume":"106","author":"Westerlund","year":"2003","journal-title":"Acta Neuropathol"},{"key":"R7-20260820","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11916-010-0123-9","article-title":"The role of chemical neurolysis in cancer pain","volume":"14","author":"Koyyalagunta","year":"2010","journal-title":"Curr Pain Headache Rep"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sja.sja_47_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:01:36Z","timestamp":1787227296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sja.sja_47_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/sja.sja_47_26","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}