{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:06Z","timestamp":1787071086224,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Potentiation of neuromuscular blocking agents by local anesthetics has been described in various clinical and experimental studies. This study assessed the influence of epidural ropivacaine on pharmacodynamic characteristics of rocuronium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a prospective randomized clinical trial at the women\u2019s hospital, an university tertiary hospital in Brazil. Sixty-two patients underwent elective abdominal surgeries requiring general anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>\n                      Patients were distributed into two groups: Group 1 (general anesthesia and epidural anesthesia) and Group 2 (general anesthesia). In Group 1, 0.2% ropivacaine at a dose of 40 mg (20 ml) was associated with 2 mg (2 ml) of morphine in a single epidural injection. The following parameters were assessed: clinical duration (DC\n                      <jats:sub>25<\/jats:sub>\n                      ) and time for recovery of the train-of-four (TOF) 0.9 ratio (T4\/T1 = 90%) after an initial 0.6 mg\/kg dose of rocuronium. The primary outcomes were DC\n                      <jats:sub>25<\/jats:sub>\n                      and TOF 0.9 ratio (T4\/T1 = 90%). Secondary outcomes were total propofol and remifentanil consumption.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Values were presented as median and interquartile range. The results for DC\n                      <jats:sub>25<\/jats:sub>\n                      and TOF 0.9 of rocuronium were, respectively, 41.5 35.0\u201355.0 (25.0\u201363.0) in Group 1 and 44.0 37.0-51.0 (20.0\u201367.0) in Group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.88); 88.0 67.0\u201399.0 (43.0\u2013137.0) in Group 1; and 80.0 71.0-86.0 (38.0\u2013155.0) in Group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.83). There was no significant difference between the groups, in terms of pharmacodynamic characteristics of rocuronium. Propofol consumption did not show any difference between the groups. However, remifentanil consumption was significantly lower in Group 1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Epidural ropivacaine, in the dose studied, did not prolong the duration of rocuronium-induced neuromuscular blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registry Number:<\/jats:title>\n                    <jats:p>ReBEC (ref: RBR-7cyp6t).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sja.sja_493_19","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T05:44:53Z","timestamp":1578375893000},"page":"63-68","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Epidural administration of ropivacaine and its effects on the pharmacodynamics of rocuronium: Randomized controlled trial. Interaction between ropivacaine and rocuronium"],"prefix":"10.4103","volume":"14","author":[{"given":"Fernando Eduardo F.","family":"Junqueira","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medical Science, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica Fatima A.","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, School of Medical Science, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Henriques","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, School of Medical Science, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin S. S.","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, School of Medical Science, State University of Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla J. B. L.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Dr. Jos\u00e9 Aristodemo Pinotti Women\u2019s Hospital, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P. C.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Dr. Jos\u00e9 Aristodemo Pinotti Women\u2019s Hospital, State University of Campinas, Campinas, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe N. C.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1213\/00000539-197809000-00014","article-title":"Interaction of muscle relaxants and local anesthetics at the neuromuscular junction","volume":"57","author":"Matsuo","year":"1978","journal-title":"Anesth Analg"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1590\/S0102-86502013001100005","article-title":"Evidence of presynaptic and postsynaptic action of local anesthetics in rats","volume":"28","author":"Braga Ade","year":"2013","journal-title":"Acta Cir Bras"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4103\/0019-5049.170019","article-title":"Effect of 50% enantiomeric excess bupivacaine mixture combined with pancuronium on neuromuscular transmission in rat phrenic nerve-diaphragm preparation; a pilot study","volume":"59","author":"de Assun\u00e7\u00e3o Braga Ade","year":"2015","journal-title":"Indian J Anaesth"},{"key":"R4-20250925","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/j.1399-6576.2010.02304.x","article-title":"Effect of an intravenous infusion of lidocaine on cisatracurium-induced neuromuscular block duration: A randomized-controlled trial","volume":"54","author":"Hans","year":"2010","journal-title":"Acta Anaesthesiol Scand"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1399-6576.1990.tb03165.x","article-title":"Effect of epidurally administered bupivacaine on atracurium-induced neuromuscular blockade","volume":"34","author":"Toft","year":"1990","journal-title":"Acta Anaesthesiol Scand"},{"key":"R6-20250925","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1399-6576.1994.tb03928.x","article-title":"The effect of epidural bupivacaine on vecuronium-induced neuromuscular blockade in children","volume":"38","author":"Taivainen","year":"1994","journal-title":"Acta Anaesthesiol Scand"},{"key":"R7-20250925","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/bja\/aem253","article-title":"Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block","volume":"99","author":"Suzuki","year":"2007","journal-title":"Br J Anaesth"},{"key":"R8-20250925","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/0310057X1103900411","article-title":"Effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block in patients undergoing lower abdominal surgery","volume":"39","author":"Sahin","year":"2011","journal-title":"Anaesth Intensive Care"},{"key":"R9-20250925","first-page":"1377","article-title":"Influence of epidural lidocaine injection on vecuronium-induced neuromuscular blockade","volume":"53","author":"Munakata","year":"2004","journal-title":"Masui"},{"key":"R10-20250925","first-page":"678","article-title":"Neuromuscular drug interactions of clinical importance","volume":"59","author":"Br\u00fcckner","year":"1980","journal-title":"Anesth Analg"},{"key":"R11-20250925","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0034-7094(09)70097-2","article-title":"Influence of local anesthetics on the neuromuscular blockade produced by rocuronium: Effects of lidocaine and 50% enantiomeric excess bupivacaine on the neuromuscular junction","volume":"59","author":"Braga Ade","year":"2009","journal-title":"Rev Bras Anestesiol"},{"key":"R12-20250925","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0102-86502009000300009","article-title":"The influence of lidocaine and racemic bupivacaine on neuromuscular blockade produced by rocuronium. A study in rat phrenic nerve-diaphragm preparation","volume":"24","author":"Carvalho","year":"2009","journal-title":"Acta Cir Bras"},{"key":"R13-20250925","first-page":"136","article-title":"Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: Experimental study","volume":"65","author":"Braga Ade","year":"2015","journal-title":"Rev Bras Anestesiol"},{"key":"R14-20250925","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1399-6576.2011.02625.x","article-title":"Intravenous lidocaine has no impact on rocuronium-induced neuromuscular block. Randomised study","volume":"56","author":"Czarnetzki","year":"2012","journal-title":"Acta Anaesthesiol Scand"},{"key":"R15-20250925","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/bja\/76.2.300","article-title":"Ropivacaine","volume":"76","author":"McClure","year":"1996","journal-title":"Br J Anaesth"},{"issue":"Suppl 1","key":"R16-20250925","first-page":"S277","article-title":"Neuromuscular block","volume":"147","author":"Bowman","year":"2006","journal-title":"Br J Pharmacol"},{"key":"R17-20250925","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1085\/jgp.52.1.144","article-title":"Alteration by xylocaine (lidocaine) and its derivatives of the time course of the end plate potential","volume":"52","author":"Steinbach","year":"1968","journal-title":"J Gen Physiol"},{"key":"R18-20250925","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0773.1988.tb00938.x","article-title":"Screening for drugs blocking acetylcholine-activated ion channels and local anaesthetics with the isolated chick biventer cervicis preparation","volume":"63","author":"MacDonald","year":"1988","journal-title":"Pharmacol Toxicol"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sja.SJA_493_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:14Z","timestamp":1787067674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sja.SJA_493_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/sja.sja_493_19","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-08-03","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}