{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:34:49Z","timestamp":1786649689201,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Ketofol, a combination of ketamine and propofol, is widely used for procedural sedation in monitored anesthesia care (MAC). While it provides analgesia and hemodynamic stability, it may be insufficient for painful procedures. Sufentanil, a potent opioid with rapid onset and moderate duration, may enhance analgesia in ketofol-based MAC. This study aimed to evaluate the efficacy and safety of adding single-dose sufentanil to ketofol in patients undergoing brief ambulatory gynecologic procedures under MAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients who received ketofol-based MAC with or without a single dose of sufentanil. Primary outcomes included postoperative pain scores at 0\u20131 and 1\u20136 h. Secondary outcomes included surgical condition scores, need for assisted ventilation, and incidence of postoperative nausea and vomiting (PONV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eighty patients were included (n = 40 per group). The sufentanil group had significantly lower pain scores in the first postoperative hour than did those of the ketofol-only group, with no difference in pain scores at 1\u20136 h. Surgical conditions were significantly better in the sufentanil group than in the ketofol-only group. However, assisted ventilation was more frequently required in the sufentanil group than in the ketofol-only group. PONV incidence was similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Adding a single dose of sufentanil to ketofol-based MAC improves early postoperative analgesia and enhances surgical conditions without prolonging the emergence time or increasing the incidence of PONV. However, it significantly increases the need for assisted ventilation, highlighting the importance of respiratory monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sja.sja_508_25","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:01:27Z","timestamp":1767337287000},"page":"68-73","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of a single dose of sufentanil as an adjunct to ketofol-based monitored anesthesia care for ambulatory surgery: A retrospective case-control study"],"prefix":"10.4103","volume":"20","author":[{"given":"Myungjin","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Haeundae Paik Hospital, Inje University, Busan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Haeundae Paik Hospital, Inje University, Busan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"123","DOI":"10.17245\/jdapm.2023.23.3.123","article-title":"Ketamine-propofol (ketofol) in procedural sedation: A narrative review","volume":"23","author":"Choi","year":"2023","journal-title":"J Dent Anesth Pain Med"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s00101-008-1331-0","article-title":"Sympathomimetic effects of low-dose S(+)-ketamine: Effect of propofol dosage","volume":"57","author":"Timm","year":"2008","journal-title":"Anaesthesist"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4097\/kjae.2011.61.2.122","article-title":"The effect-site concentration of propofol producing respiratory depression during spinal anesthesia","volume":"61","author":"Lee","year":"2011","journal-title":"Korean J Anesthesiol"},{"key":"R4-20260421","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11916-023-01208-0","article-title":"Efficacy and safety of ketamine-dexmedetomidine versus ketamine-propofol combination for periprocedural sedation: A systematic review and meta-analysis","volume":"28","author":"Elsaeidy","year":"2024","journal-title":"Curr Pain Headache Rep"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.21037\/jtd-21-296","article-title":"Risk factors for postoperative nausea and vomiting after thoracoscopic pulmonary wedge resection: Pitfalls of an increased fentanyl dose","volume":"13","author":"Nakai","year":"2021","journal-title":"J Thorac Dis"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.7150\/ijms.34656","article-title":"Comparison of the analgesic effect of sufentanil versus fentanyl in intravenous patient-controlled analgesia after total laparoscopic hysterectomy: A randomized, double-blind, prospective study","volume":"16","author":"Oh","year":"2019","journal-title":"Int J Med Sci"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bjan.2018.12.011","article-title":"Sufentanil during anesthetic induction of remifentanil-based total intravenous anesthesia: A randomized controlled trial","volume":"69","author":"Menezes","year":"2019","journal-title":"Braz J Anesthesiol"},{"key":"R8-20260421","first-page":"282","article-title":"Total intravenous anesthesia with ketofol versus combination of ketofol and lidocaine for short-term anesthesia in pediatric patients; double blind, randomized clinical trial of effects on recovery","volume":"9","author":"Neve\u0161\u0107anin Bili\u0161kov","year":"2022","journal-title":"Children (Basel, Switzerland)"},{"key":"R9-20260421","doi-asserted-by":"crossref","first-page":"701329","DOI":"10.1155\/2014\/701329","article-title":"The effect of sufentanil administration on remifentanil-based anaesthesia during laparoscopic gynaecological surgery: A double-blind randomized controlled trial","volume":"2014","author":"Son","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"R10-20260421","doi-asserted-by":"crossref","first-page":"ojac040","DOI":"10.1093\/asjof\/ojac040","article-title":"Sufentanil sublingual tablet reduces postoperative opioid use following outpatient plastic surgery","volume":"4","author":"Seify","year":"2022","journal-title":"Aesthetic Surg J Open Forum"},{"key":"R11-20260421","doi-asserted-by":"crossref","first-page":"102809","DOI":"10.1016\/j.amjoto.2020.102809","article-title":"Comparison of general anesthesia and monitored anesthesia care for sialendoscopy procedures","volume":"42","author":"Mastrolonardo","year":"2021","journal-title":"Am J Otolaryngol"},{"key":"R12-20260421","first-page":"533","article-title":"Monitored anesthesia care","volume":"71","author":"Ghisi","year":"2005","journal-title":"Minerva Anestesiol"},{"key":"R13-20260421","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1097\/00000539-200106000-00022","article-title":"The effects of small-dose ketamine on propofol sedation: Respiration, postoperative mood, perception, cognition, and pain","volume":"92","author":"Mortero","year":"2001","journal-title":"Anesth Analg"},{"key":"R14-20260421","first-page":"102","article-title":"Effect of lidocaine, fentanyl, or dexmedetomidine on minimum infusion rate and cardiorespiratory variables in dogs undergoing ketofol total intravenous anesthesia","volume":"24","author":"Khannejad","year":"2023","journal-title":"Iran J Vet Res"},{"key":"R15-20260421","first-page":"455","article-title":"Sufentanil vs fentanyl for fast-track cardiac anaesthesia","volume":"53","author":"Deshpande","year":"2009","journal-title":"Indian J Anaesth"},{"key":"R16-20260421","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/bja\/aeg263","article-title":"Influence of peroperative opioid on postoperative pain after major abdominal surgery: Sufentanil TCI versus remifentanil TCI. 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