{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:40:17Z","timestamp":1787071217387,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sepsis and septic shock are among the leading causes of morbidity and mortality worldwide. Hypoalbuminemia is commonly observed preoperatively and may serve as a prognostic factor for predicting severity of sepsis and septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A cross-sectional, prospective descriptive study was conducted on 122 surgical adult patients diagnosed with sepsis or septic shock according to the Sepsis-3 criteria. All patients were admitted to the intensive care unit from April 2023 to May 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 46 patients (37.7%) were diagnosed with sepsis and 76 patients (62.3%) developed septic shock. The septic shock group had significantly longer hospital stays compared to the sepsis group (7 days vs. 4 days, respectively) and higher mortality rates (52.6% vs. 10.9%, respectively). Hypoalbuminemia was present in 89.3% of all patients, with 22.1% patients having severe hypoalbuminemia. There was a significant difference in mortality rates between patients with hypoalbuminemia and normal albumin level (40.4% vs. 7.7%, respectively). The mortality rate of severe hypoalbuminemia patients was also higher (48.1%) than non-severe hypoalbuminemia (37.8%) and normal albumin levels (7.7%). The adjusted odds ratio for post-operative in-hospital death comparing patients with hypoalbuminemia and patients with normal albumin level was 8.12 [1.02\u201364.73]. A preoperative hypoalbuminemia with cutoff of 29.8 g\/L was the prognostic factor for mortality with an area under the receiver operating characteristic curve (AUROC) of 67.3%, sensitivity of 78.6%, and specificity of 56.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Preoperative albumin level was the potential prognostic indicator for severity and should be considered in the risk stratification model for patients with surgical sepsis and septic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sja.sja_627_25","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T07:00:32Z","timestamp":1775199632000},"page":"344-350","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Preoperative hypoalbuminemia as a prognosis indicator in patients with surgical 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