{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:54Z","timestamp":1787071074854,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"\n Background and Aims:<\/jats:title>\n Anaesthesia for children undergoing magnetic resonance imaging (MRI) ranges from moderate to deep sedation in order to facilitate uninterrupted completion of the scan. While various intravenous and inhalational techniques of anaesthesia have their own merits and demerits, there is a paucity of comparative literature between the two in children undergoing diagnostic MRI.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This prospective observational cohort study was conducted at the Radiology suite of a 2800-bedded tertiary care hospital, wherein 107 unpremedicated children between the ages of 6 months to 15 years received either sedation with propofol infusion (Group GSP,\n n<\/jats:italic>\n = 57) or inhalational anaesthesia with a laryngeal mask airway (Group GAL,\n n<\/jats:italic>\n = 50). Primary outcome measures included time to induction and time to recovery. Secondary outcomes comprised the incidence of respiratory and non-respiratory adverse events in the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The median time to induction was significantly shorter in GSP than GAL [7.00 (IQR 5.0, 10.0) versus 10.00 minutes (IQR 8.8, 13.0),\n P<\/jats:italic>\n < 0.001]; the incidence of desaturation [8 (16.0%) in GAL, 1 (1.8%) in GSP,\n P<\/jats:italic>\n = 0.012], laryngospasm [11 (22.4%) in GAL, 1 (1.8%) in GSP,\n P<\/jats:italic>\n = 0.001] and emergence delirium (5 (10%) in GAL, 0 in GSP,\n P<\/jats:italic>\n = 0.047) were significantly greater in the GAL group. There was no difference in the time to emergence, nausea and vomiting or bradycardia between the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Sedation with propofol infusion during paediatric MRI scan offers a short turnover time and favourable adverse event profile when compared to inhalational anaesthesia with an LMA.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sja.sja_741_19","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:56:55Z","timestamp":1598605015000},"page":"311-317","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Timeliness of care and adverse event profile in children undergoing general anesthesia or sedation for MRI: An observational prospective cohort study"],"prefix":"10.4103","volume":"14","author":[{"given":"Suma Mary","family":"Thampi","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poornima","family":"Kothandan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Jiwanmall","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1460-9592.2008.02900.x","article-title":"Sedation medication received and adverse events related to sedation for brain MRI in children with and without developmental disabilities","volume":"19","author":"Kannikeswaran","year":"2009","journal-title":"Paediatr Anaesth"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1542\/peds.2006-2780","article-title":"Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures: An update","volume":"118","author":"Cot\u00e9","year":"2006","journal-title":"Pediatrics"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/ACO.0b013e32833bb524","article-title":"Anaesthesia or sedation for MRI in children","volume":"23","author":"Schulte-Uentrop","year":"2010","journal-title":"Curr Opin Anaesthesiol"},{"key":"R4-20250925","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/ACO.0b013e3283620121","article-title":"Anaesthesia or sedation for paediatric MRI: Advantages and disadvantages","volume":"26","author":"Arthurs","year":"2013","journal-title":"Curr Opin Anaesthesiol"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/ACO.0b013e328304115b","article-title":"Anaesthesia for MRI in the paediatric patient","volume":"21","author":"Serafini","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"key":"R6-20250925","doi-asserted-by":"crossref","first-page":"e1018","DOI":"10.1259\/bjr\/28871143","article-title":"Sedation\/anaesthesia in paediatric radiology","volume":"85","author":"Arlachov","year":"2012","journal-title":"Br J Radiol"},{"key":"R7-20250925","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/oxfordjournals.bja.a013586","article-title":"Sedation and general anaesthesia in children undergoing MRI and CT: Adverse events and outcomes","volume":"84","author":"Malviya","year":"2000","journal-title":"Br J Anaesth"},{"key":"R8-20250925","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1213\/ANE.0000000000000504","article-title":"Propofol anesthesia for children undergoing magnetic resonance imaging: A comparison with isoflurane, nitrous oxide, and a laryngeal mask airway","volume":"120","author":"Heard","year":"2015","journal-title":"Anesth Analg"},{"key":"R9-20250925","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1460-9592.2009.03048.x","article-title":"Arandomized trial comparing sevoflurane and propofol in children undergoing MRI scans","volume":"19","author":"Bryan","year":"2009","journal-title":"Paediatr Anaesth"},{"key":"R10-20250925","first-page":"39","article-title":"Major morbidity or mortality from office anesthetic procedures: A closed-claim analysis of 13 cases","volume":"38","author":"Jastak","year":"1991","journal-title":"Anesth Prog"},{"key":"R11-20250925","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/j.1460-9592.2006.01959.x","article-title":"Outpatient arthroscopic knee surgery under combined local and intravenous propofol anesthesia in children and adolescents","volume":"16","author":"Maldini","year":"2006","journal-title":"Paediatr Anaesth"},{"key":"R12-20250925","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/bja\/aen153","article-title":"Propofol-based sedation regimen for infants and children undergoing ambulatory magnetic resonance imaging","volume":"101","author":"Machata","year":"2008","journal-title":"Br J Anaesth"},{"key":"R13-20250925","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1097\/00000542-200512000-00007","article-title":"Respiratory reflex responses of the larynx differ between sevoflurane and propofol in pediatric patients","volume":"103","author":"Oberer","year":"2005","journal-title":"Anesthesiology"},{"key":"R14-20250925","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1213\/01.ANE.0000070227.78670.43","article-title":"The effect of small dose fentanyl on the emergence characteristics of pediatric patients after sevoflurane anesthesia without surgery","volume":"97","author":"Cravero","year":"2003","journal-title":"Anesth Analg"},{"key":"R15-20250925","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/BF03021048","article-title":"Anesthesia for magnetic resonance imaging in children: A survey of Canadian pediatric centres","volume":"50","author":"Usher","year":"2003","journal-title":"Can J Anaesth"},{"key":"R16-20250925","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/aas.12151","article-title":"Propofol-remifentanil or sevoflurane for children undergoing magnetic resonance imaging? A randomised study","volume":"57","author":"Pedersen","year":"2013","journal-title":"Acta Anaesthesiol Scand"}],"container-title":["Saudi Journal of Anaesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sja.SJA_741_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:05Z","timestamp":1787067665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sja.SJA_741_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,30]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/sja.sja_741_19","relation":{},"ISSN":["1658-354X","0975-3125"],"issn-type":[{"value":"1658-354X","type":"print"},{"value":"0975-3125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,30]]},"assertion":[{"value":"2019-11-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}