{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:13Z","timestamp":1786649413828,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Background:<\/jats:title>\n Liver transplantation is frequently associated with massive blood loss and utilization of blood products to optimize coagulation; this study aimed to evaluate their possible correlation with etiological and perioperative factors.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective analysis of adult liver transplant (LT) recipients (excluding re-do transplants) operated upon at our center between 2011 and 2021 was conducted using R package with rBiostatistics.com graphical user interface.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 947 cases, 70.70% had cirrhosis, and 28.6% hepatocellular carcinoma, as secondary diagnoses; the most common primary diagnosis was viral hepatitis (B = 20.9% and C = 20.0%). The mean blood loss volume was 3393.2 ml. Living donor liver transplantation (LDLT) recipients (n = 740, 78.2%) had lesser blood loss (mean difference 738 mL,\n P<\/jats:italic>\n = 0.037) and reduced requirement for fresh frozen plasma (FFP, OR = 0.734,\n P<\/jats:italic>\n = 0.001) and platelets (OR = 0.809,\n P<\/jats:italic>\n < 0.001). Presence of hepatocellular carcinoma (n = 273, 28.6%) was significantly protective for blood loss (mean difference 717 ml,\n P<\/jats:italic>\n = 0.037) and the need for FFP (OR = 0.991,\n P<\/jats:italic>\n < 0.001), cryoprecipitate (OR = 0.568,\n P<\/jats:italic>\n = 0.001), and platelets (OR = 0.602,\n P<\/jats:italic>\n < 0.001). Schistosomiasis (\n n<\/jats:italic>\n = 23, 2.4%) was accompanied by increased blood loss (mean difference 2328 ml (\n P<\/jats:italic>\n = 0.012)). A body mass index (BMI) >35 kg\/m\n 2<\/jats:sup>\n increased the hazard of cryoprecipitate requirement (OR = 1.203,\n P<\/jats:italic>\n = 0.008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The blood loss and the blood products transfusion requirements in LT are influenced by the etiology, graft type, and other perioperative factors such as BMI.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sja.sja_76_25","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:01:24Z","timestamp":1756900884000},"page":"505-513","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of correlation between etiology of end stage liver disease and intraoperative utilization of blood products during liver transplantation"],"prefix":"10.4103","volume":"19","author":[{"given":"Amer","family":"Majeed","sequence":"first","affiliation":[{"name":"Department of Abdominal Transplant Anesthesia, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basel A.","family":"Jobeir","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplant Anesthesia, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, University Hospitals of North Midlands NHST, Stoke-on-Trent, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad S.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, TN, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Tufail","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Montefiore Medical Center, Bronx, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri A.","family":"Raptis","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplant and Hepatobiliary Surgery, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luluah","family":"Altukhaifi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej A. G.","family":"AlFattani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"R1-20260421","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.3748\/wjg.v28.i40.5881","article-title":"Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade: A single-center experience","volume":"28","author":"Cervantes-Alvarez","year":"2022","journal-title":"World J Gastroenterol"},{"key":"R2-20260421","doi-asserted-by":"crossref","first-page":"507","DOI":"10.6002\/ect.2016.0325","article-title":"The impact of preoperative variables on intraoperative blood loss and transfusion requirements during orthotopic liver transplant","volume":"17","author":"Eghbal","year":"2019","journal-title":"Exp Clin Transplant"},{"key":"R3-20260421","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4240\/wjgs.v7.i6.86","article-title":"Intraoperative blood loss in orthotopic liver transplantation: The predictive factors","volume":"7","author":"Pandey","year":"2015","journal-title":"World J Gastrointest Surg"},{"key":"R4-20260421","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3390\/biomedicines11041093","article-title":"Patient blood management in liver transplant\u2014A concise review","volume":"11","author":"P\u00e9rez-Calatayud","year":"2023","journal-title":"Biomedicines"},{"key":"R5-20260421","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jhep.2021.08.018","article-title":"Risk of transfusion-transmitted hepatitis E virus infection from pool-tested platelets and plasma","volume":"76","author":"Cordes","year":"2022","journal-title":"J Hepatol"},{"key":"R6-20260421","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jamcollsurg.2012.12.047","article-title":"Blood transfusion requirement during liver transplantation is an important risk factor for mortality","volume":"216","author":"Rana","year":"2013","journal-title":"J Am Coll Surg"},{"key":"R7-20260421","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.ajt.2024.04.020","article-title":"Robotic living donor hepatectomy is associated with superior outcomes for both the donor and the recipient compared with laparoscopic or open - 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