{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:29:50Z","timestamp":1787758190724,"version":"build-2784847793"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      To investigage the thiol and disulphide levels in\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      -positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. First, blood samples were drawn from patients to determine their serum thiol and disulphide levels. Endoscopic biopsy was performed on all patients and the biopsy specimens obtained were examined pathologically. Patients positive for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      were administered eradication therapy. Blood samples were drawn from these patients for the second time, and their serum thiol and disulphide levels were measured. The thiol\u2013disulfide levels of the patients who were successful in\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication treatment, with those who were not, were compared before and after the treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean plasma disulphide level decreased significantly from 14.0 \u00b1 6.6 to 10.9 \u00b1 5.9 \u03bcmol\/L in\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      -positive patients that responded to the\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication treatment (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.033). On the other hand, there was an insignificant increase in the mean serum thiol level (341.4 \u00b1 30.5 vs. 342.6 \u00b1 29.8 \u03bcmol\/L;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.273) and an insignificant decrease in the mean serum disulphide level (15.2 \u00b1 2.5 vs. 14.8 \u00b1 2.3 \u03bcmol\/L;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.163) in\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      -positive patients that did not respond to the\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      eradication treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The inflammation caused by\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      shifted the thiol\u2013disulphide equilibrium in the cell redox system towards the direction of disulphide. The study findings suggest that the restoration of the said hemostatic balance with eradication therapy relieved the organism from oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjg.sjg_114_22","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T05:36:18Z","timestamp":1659936978000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia"],"prefix":"10.4103","volume":"28","author":[{"given":"Berat","family":"Ebik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihat","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naz\u0131m","family":"Ekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhat","family":"Bacaksiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medeni","family":"Arpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Neselioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozcan","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyzullah","family":"Ucmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240829","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/j.1572-0241.2007.01335.x","article-title":"\u201cThe association between Helicobacter pylori infection and early gastric cancer: A meta-analysis\u201d","volume":"102","author":"Wang","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"R2-6-20240829","doi-asserted-by":"crossref","first-page":"e12644","DOI":"10.1111\/hel.12644","article-title":"Review: Helicobacter: Inflammation, immunology, and vaccines","volume":"24","author":"Lehours","year":"2019","journal-title":"Helicobacter"},{"key":"R3-6-20240829","doi-asserted-by":"crossref","first-page":"e12406","DOI":"10.1111\/hel.12406","article-title":"Helicobacter: Inflammation, immunology and vaccines","volume":"22","author":"Robinson","year":"2017","journal-title":"Helicobacter"},{"key":"R4-6-20240829","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1016\/S0140-6736(84)91886-5","article-title":"Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy","volume":"1","author":"Halliwell","year":"1984","journal-title":"Lancet"},{"key":"R5-6-20240829","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-chembioeng-080615-033553","article-title":"Thiol-disulfide exchange reactions in the mammalian extracellular environment","volume":"7","author":"Yi","year":"2016","journal-title":"Annu Rev Chem Biomol Eng"},{"key":"R6-6-20240829","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2014.06.012","article-title":"Disulfide-containing parenteral delivery systems and their redox-biological fate","volume":"195","author":"Brulisauer","year":"2014","journal-title":"J Control Release"},{"key":"R7-6-20240829","doi-asserted-by":"crossref","first-page":"22040","DOI":"10.1074\/jbc.M703591200","article-title":"Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: Implications for mitochondrial redox signalling","volume":"282","author":"Hurd","year":"2007","journal-title":"J Biol Chem"},{"key":"R8-6-20240829","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3906\/sag-2003-64","article-title":"Thiol-disulfide homeostasis: An integrated approach with biochemical and clinical aspects","volume":"50","author":"Erel","year":"2020","journal-title":"Turk J Med Sci"},{"key":"R9-6-20240829","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0891-5849(02)00868-7","article-title":"Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress","volume":"33","author":"Naito","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"R10-6-20240829","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri1312","article-title":"NOX enzymes and the biology of reactive oxygen","volume":"4","author":"Lambeth","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"R11-6-20240829","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jcmgh.2017.02.002","article-title":"Oxidative stress resulting fromhelicobacter pylori\u0131nfectioncontributes to gastric carcinogenesis","volume":"3","author":"Butcher","year":"2017","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"R12-6-20240829","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"R13-6-20240829","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3109\/10409238.2013.764840","article-title":"Thiol\/disulfide redox states in signalling and sensing","volume":"48","author":"Go","year":"2013","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"R14-6-20240829","first-page":"2477","article-title":"Effects of smoking on thiol\/disulfide homeostasis","volume":"22","author":"Solak","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R15-6-20240829","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10096-018-3414-4","article-title":"Diagnostic methods for Helicobacter pylori infection: Ideals, options, and limitations","volume":"38","author":"Sabbagh","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"R16-6-20240829","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis The updated Sydney System International Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"R17-6-20240829","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1523-5378.2010.00758.x","article-title":"High efficacy of 14-day triple therapy-based, bismuth-containing quadruple therapy for initial Helicobacter pylori eradication","volume":"15","author":"Sun","year":"2010","journal-title":"Helicobacter"},{"key":"R18-6-20240829","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.3748\/wjg.v11.i37.5878","article-title":"Comparison of a monoclonal antigen stool test (Hp StAR) with the 13C-urea breath test in monitoring Helicobacter pylori eradication therapy","volume":"11","author":"Perri","year":"2005","journal-title":"World J Gastroenterol"},{"key":"R19-6-20240829","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","article-title":"A novel and automated assay for thiol\/disulphide homeostasis","volume":"47","author":"Erel","year":"2014","journal-title":"Clin Biochem"},{"key":"R20-6-20240829","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2036.2008.03852.x","article-title":"Clinical trial: Arandomized trial of early endoscopy, Helicobacter pylori testing and empirical therapy for the management of dyspepsia in primary care","volume":"29","author":"Duggan","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"R21-6-20240829","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.freeradbiomed.2009.08.021","article-title":"Measuring the poise of thiol\/disulfide couples in vivo","volume":"47","author":"Jones","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"R22-6-20240829","first-page":"1063","article-title":"Serum antioxidant capacity and oxidative injury to pulmonary DNA in never-smokers with primary lung cancer","volume":"32","author":"Ito","year":"2012","journal-title":"Anticancer Res"},{"key":"R23-6-20240829","first-page":"1279250","article-title":"Approaches and methods to measure oxidative stress in clinical samples: Research applications in the cancer field","volume":"2019","author":"Katerji","year":"2019","journal-title":"OxidMedCell Longev"},{"key":"R24-6-20240829","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/10408360903142326","article-title":"Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers","volume":"46","author":"Giustarini","year":"2009","journal-title":"Crit Rev Clin Lab Sci"},{"key":"R25-6-20240829","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jsps.2012.05.002","article-title":"Review on in vivo and in vitro methods evaluation of antioxidant activity","volume":"21","author":"Alam","year":"2013","journal-title":"Saudi Pharm J"},{"key":"R26-6-20240829","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"key":"R27-6-20240829","doi-asserted-by":"crossref","first-page":"948","DOI":"10.18621\/eurj.443557","article-title":"Thiol\/disulphide homeostasis in H.pylori infected patients","volume":"5","author":"Baykan","year":"2019","journal-title":"The European Research Journal"},{"key":"R28-6-20240829","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1574-695X.2007.00259.x","article-title":"Potential role of thiol: disulfide oxidoreductases in the pathogenesis of Helicobacter pylori","volume":"50","author":"Kaakoush","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R29-6-20240829","doi-asserted-by":"crossref","first-page":"867","DOI":"10.7754\/Clin.Lab.2017.161117","article-title":"Clinical utility of thiol\/disulfide homeostasis","volume":"63","author":"Erenler","year":"2017","journal-title":"Clin Lab"},{"key":"R30-6-20240829","doi-asserted-by":"crossref","first-page":"75e103","DOI":"10.1016\/j.freeradbiomed.2016.12.048","article-title":"Redox signaling in the gastrointestinal tract","volume":"104","author":"Perez","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"R31-6-20240829","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1042\/BST0391268","article-title":"Thiol regulation of pro-inflammatory cytokines and innate immunity: Protein S-thiolation as a novel molecular mechanism","volume":"39","author":"Coppo","year":"2011","journal-title":"Biochem Soc Trans"},{"key":"R32-6-20240829","doi-asserted-by":"crossref","first-page":"e12535","DOI":"10.1111\/hel.12535","article-title":"The effect of antioxidants on Helicobacter pylori eradication: A systematic review with meta-analysis","volume":"23","author":"Yang-Ou","year":"2018","journal-title":"Helicobacter"},{"key":"R33-6-20240829","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.clinre.2011.07.001","article-title":"Efficacy of vitamin supplementation to therapy on Helicobacter pylori eradication in patients with low antioxidant capacity","volume":"35","author":"Sezikli","year":"2011","journal-title":"Clin Res Hepatol Gastroenterol"}],"container-title":["Saudi Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjg.sjg_114_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:08:38Z","timestamp":1787756918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjg.sjg_114_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/sjg.sjg_114_22","relation":{},"ISSN":["1319-3767"],"issn-type":[{"value":"1319-3767","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}