{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:18:26Z","timestamp":1793319506752,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Updated Sydney system (USS) recommends taking biopsies from certain areas of the stomach for the diagnosis of precancerous lesions associated with\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      . Our aim was to evaluate the contribution of each of the biopsy sites to the diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective study included 97 patients aged 40 and over with dyspeptic complaints. Biopsies were taken from five regions: the lesser curvature of the antrum (LCA), the lesser curvature of the corpus (LCC), incisura angularis (IA), the greater curvature of the antrum (GCA), and the greater curvature of the corpus (GCC). Biopsy specimens were stained with hematoxylin\u2013eosin stain, periodic acid Schiff\u2013alcian blue, and Giemsa histochemical stain and evaluated according to the Sydney classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Thirty-seven (38%) patients were positive for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in at least one biopsy site. Atrophic gastritis without intestinal metaplasia (IM) was found in 17 (17.5%) of the patients (6.2% in IA, 5.2% in each of LCA, GCA, and LCC, and 2% in GCC). The prevalence of atrophic gastritis with IM was 42.3% (21.6% in LCA, 20.6% in GCA, 20.6% in IA, 14.4% in LCC, and 5.2% in GCC). Endoscopic follow-up was planned in 21 (22%) patients due to the presence of extensive atrophy or incomplete IM. If a single biopsy of the LCA or a biopsy of both LCA and GCA was taken, endoscopic follow-up would have been missed in 12 (57%) or 6 (29%) patients, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Taking biopsies in accordance with the USS had higher sensitivity in detecting atrophic gastritis with or without IM compared to single biopsy. One or two biopsies is not sufficient to identify patients for whom endoscopic follow-up is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjg.sjg_146_22","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T06:58:24Z","timestamp":1658818704000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of the diagnostic accuracy of the updated Sydney system and single biopsy"],"prefix":"10.4103","volume":"28","author":[{"given":"Cundullah","family":"Torun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arda","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kubra","family":"Akan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Seneldir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Nur","family":"Toksoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Celal","family":"Ulasoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240829","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R2-7-20240829","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/a-0859-1883","article-title":"Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019","volume":"51","author":"Pimentel-Nunes","year":"2019","journal-title":"Endoscopy"},{"key":"R3-7-20240829","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2012","journal-title":"J Dig Dis"},{"key":"R4-7-20240829","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/hel.12071","article-title":"Diagnosis and epidemiology of Helicobacter pylori infection","volume":"18","author":"Calvet","year":"2013","journal-title":"Helicobacter"},{"key":"R5-7-20240829","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"R6-7-20240829","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/apt.14424","article-title":"Reversibility of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication \u2013 A prospective study for up to 10 years","volume":"47","author":"Hwang","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"R7-7-20240829","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/gast.2000.8550","article-title":"Atrophy and intestinal metaplasia one year after cure of H.pylori infection: A prospective, randomized study","volume":"119","author":"Sung","year":"2000","journal-title":"Gastroenterology"},{"key":"R8-7-20240829","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1053\/bega.2001.0253","article-title":"Atrophy-metaplasia-dysplasia-carcinoma sequence in the stomach: A reality or merely an hypothesis?","volume":"15","author":"Meining","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"R9-7-20240829","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1055\/s-0042-108435","article-title":"A multicenter prospective study of the real-time use of narrow-band imaging in the diagnosis of premalignant gastric conditions and lesions","volume":"48","author":"Pimentel-Nunes","year":"2016","journal-title":"Endoscopy"},{"key":"R10-7-20240829","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1440-1746.1991.tb01469.x","article-title":"The Sydney System: Endoscopic division. 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