{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:33:33Z","timestamp":1787758413673,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Esophageal motility disorders (EMDs) can significantly impact patients\u2019 quality of life. The Chicago Classification (CC) was developed as a robust framework to enable clinicians to better understand and classify the nature of motility disorders. Previous studies have primarily focused on the CC version 3.0 (CCv3.0), and data regarding the correlation between symptoms and CC version 4.0 (CCv4.0) in the Saudi Arabian population are lacking. This study aimed to assess the correlation between symptoms and CCv3.0 and CCv4.0 using high-resolution esophageal manometry (HRM) in Saudi Arabia, to evaluate the diagnostic performance of both classifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 182 patients presenting with esophageal symptoms were included in this study. HRM was performed to assess esophageal motility, and patients\u2019 reported symptoms were recorded. The association between HRM findings and symptomatic variables was analyzed using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Variability was observed in the diagnostic performance of symptomatic variables for major EMDs. CCv4.0 demonstrated a higher sensitivity for dysphagia than CCv3.0; however, it exhibited lower sensitivity to atypical gastroesophageal reflux disease (GERD) symptoms. Noncardiac chest pain (NCCP) exhibited the highest specificity and PPV, whereas typical GERD symptoms showed lower specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>CCv4.0 demonstrated potential improvements in sensitivity for dysphagia, but lower sensitivity for atypical GERD symptoms, compared with CCv3.0. These insights provide guidance for clinicians in Saudi Arabia and contribute to understanding the diagnostic performance of CCv3.0 and CCv4.0.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjg.sjg_243_23","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T06:07:54Z","timestamp":1691647674000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Association of esophageal motility disorder symptoms with Chicago classification versions 3.0 and 4.0 using high-resolution esophageal manometry: A single-center experience from Saudi Arabia"],"prefix":"10.4103","volume":"30","author":[{"given":"Mohammed A.","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, King Khalid University, Aseer Central Hospital, Abha, Saudi 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M.","family":"Alahmari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Aseer Central Hospital, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Al-Shahrani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, King Khalid University, Aseer Central Hospital, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz S.","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Najran University, Najran, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"Almanjahi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Aseer Central Hospital, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M.","family":"Alqarni","sequence":"additional","affiliation":[{"name":"Department of Occupational Health, Aseer Central Hospital, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/nmo.12477","article-title":"The Chicago Classification of esophageal motility disorders, v3.0","volume":"27","author":"Kahrilas","year":"2015","journal-title":"Neurogastroenterol Motil"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.cgh.2018.04.026","article-title":"Advances in management of esophageal motility disorders","volume":"16","author":"Kahrilas","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11894-017-0576-7","article-title":"Chicago classification of esophageal motility 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