{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:49:12Z","timestamp":1792050552019,"version":"4.4.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Liver transplantation (LT) was first introduced in the early 1960s, with early paediatric experience marked by significant technical challenges and high risk. Advances in surgical techniques and immunosuppressive therapy in the late 1970s led to successful paediatric LT outcomes, while continued improvements throughout the 1980s and 1990s have enhanced survival and reduced complications. Current 10-year graft and patient survival rates for elective paediatric indications exceed 90%. Over the past two decades, LT has increasingly been used to treat inherited metabolic diseases (IMDs), which now account for 25\u201330% of paediatric LT. Initially recommended for tyrosinaemia type 1 in 1978 and later for urea cycle disorders such as ornithine transcarbamylase deficiency, LT can be curative when the metabolic defect is confined to the liver and partially corrective in conditions with extrahepatic involvement. As indications expand and earlier intervention is emphasized, this review examines the role of LT in IMDs, highlighting current concepts, challenges, and controversies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjg.sjg_325_25","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:00:08Z","timestamp":1772895608000},"page":"177-181","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric liver transplantation for inherited metabolic disease\u2014Current challenges"],"prefix":"10.4103","volume":"32","author":[{"given":"Roshni","family":"Vara","sequence":"first","affiliation":[{"name":"Department of Metabolic Medicine, Evelina Children\u2019s Hospital, London, UK"},{"name":"Paediatric Liver Service, King\u2019s College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedim","family":"Hadzic","sequence":"additional","affiliation":[{"name":"Paediatric Liver Service, King\u2019s College Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"R1-20261015","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/lt.25433","article-title":"Evolving trends in liver transplant for metabolic liver disease in the United States","volume":"25","author":"McKiernan","year":"2019","journal-title":"Liver Transpl"},{"key":"R2-20261015","doi-asserted-by":"crossref","first-page":"e14625","DOI":"10.1111\/petr.14625","article-title":"Current status and future directions of liver transplantation for metabolic liver disease in children","volume":"28","author":"Eldredge","year":"2024","journal-title":"Pediatr 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