{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:16:49Z","timestamp":1791238609125,"version":"4.1.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"\n Background:<\/jats:title>\n \n This study aimed to investigate the efficacy of\n P. oleracea<\/jats:italic>\n in the management of patients with functional constipation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n A total of 60 patients with functional constipation as defined by the Rome IV criteria were enrolled in this randomized, double-blind, placebo-controlled study; 70% ethanol extracts of the aerial parts of\n P. oleracea<\/jats:italic>\n were used for the intervention. Patients were randomly assigned to the\n P. oleracea<\/jats:italic>\n or placebo groups. Treatment response, quality of life, and changes in colonic transit time (CTT) were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Complete spontaneous bowel movement (CSBM) improved significantly in the\n P. oleracea<\/jats:italic>\n group compared with that in the placebo group over 8 weeks of treatment (\n P<\/jats:italic>\n = 0.003). Overall Patient Assessment of Constipation Quality of Life (PAC-QOL) and Patient Assessment of Constipation Symptoms (PAC-SYM) score improvements were observed in the\n P. oleracea<\/jats:italic>\n group (\n P<\/jats:italic>\n < 0.05). Moreover, CTT decreased from 44.5 \u00b1 22.0 h to 33.7 \u00b1 22.7 h in the\n P. oleracea<\/jats:italic>\n group after 7 weeks of treatment (\n P<\/jats:italic>\n = 0.04). There were no significant differences in the Bristol Stool Form Scale (BSFS) or adverse events between the groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Compared to placebo, the use of\n P. oleracea<\/jats:italic>\n in patients with functional constipation significantly improved CSBM, severity of symptoms, and quality of life. Further large studies are required to assess the benefits of\n P. oleracea<\/jats:italic>\n in the treatment of functional constipation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sjg.sjg_400_21","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T03:29:23Z","timestamp":1657769363000},"page":"296-303","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Portulaca Oleracea L. extract on functional constipation"],"prefix":"10.4103","volume":"28","author":[{"given":"Ki Bae","family":"Bang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun-Chual","family":"Rho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung W.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Eun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240829","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5056\/jnm15185","article-title":"Guidelines for the diagnosis and treatment of chronic functional constipation in Korea, 2015 revised edition","volume":"22","author":"Shin","year":"2016","journal-title":"J Neurogastroenterol Motil"},{"key":"R2-8-20240829","doi-asserted-by":"crossref","first-page":"e13441","DOI":"10.1111\/nmo.13441","article-title":"Nonpharmacological conservative treatments for chronic functional constipation: A systematic review and network meta-analysis","volume":"31","author":"Zheng","year":"2019","journal-title":"Neurogastroenterol Motil"},{"key":"R3-8-20240829","doi-asserted-by":"crossref","first-page":"e13762","DOI":"10.1111\/nmo.13762","article-title":"European society of neurogastroenterology and motility guidelines on functional constipation in adults","volume":"32","author":"Serra","year":"2020","journal-title":"Neurogastroenterol Motil"},{"key":"R4-8-20240829","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1007\/s12325-017-0633-5","article-title":"The better understanding and recognition of the disconnects, experiences, and needs of patients with chronic idiopathic constipation (BURDEN-CIC) study: Results of an online questionnaire","volume":"34","author":"Harris","year":"2017","journal-title":"Adv Ther"},{"key":"R5-8-20240829","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1080\/14740338.2017.1361402","article-title":"The safety of available treatments for chronic constipation","volume":"16","author":"Serrano-Falc\u00f3n","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"R6-8-20240829","doi-asserted-by":"crossref","first-page":"925631","DOI":"10.1155\/2015\/925631","article-title":"Portulaca oleracea L.: A review of phytochemistry and pharmacological effects","volume":"2015","author":"Zhou","year":"2015","journal-title":"BioMed Res Int"},{"key":"R7-8-20240829","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3831\/KPI.2019.22.001","article-title":"A pharmacological review on Portulaca oleracea L.: Focusing on anti-inflammatory, anti- oxidant, immuno-modulatory and antitumor activities","volume":"22","author":"Rahimi","year":"2019","journal-title":"J Pharmacopuncture"},{"key":"R8-8-20240829","first-page":"37","article-title":"Bioactive effects of a herbal formula KDC16-2 consisting Portulaca oleracea L.extracts","volume":"50","author":"Hur","year":"2019","journal-title":"Korean J Pharmacogn"},{"key":"R9-8-20240829","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.foodres.2017.12.058","article-title":"Portulaca oleracea extracts and their active compounds ameliorate inflammatory bowel diseases in vitro and in vivo by modulating TNF-\u03b1, IL-6 and IL-1\u03b2 signalling","volume":"106","author":"Kim","year":"2018","journal-title":"Food Res Int"},{"key":"R10-8-20240829","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel disorders","volume":"150","author":"Mearin","year":"2016","journal-title":"Gastroenterology"},{"key":"R11-8-20240829","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3109\/00365529709011203","article-title":"Stool form scale as a useful guide to intestinal transit time","volume":"32","author":"Lewis","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"R12-8-20240829","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1080\/003655299750025327","article-title":"Psychometric validation of a constipation symptom assessment questionnaire","volume":"34","author":"Frank","year":"1999","journal-title":"Scand J Gastroenterol"},{"key":"R13-8-20240829","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/00365520510012208","article-title":"Development and validation of the patient assessment of constipation quality of life questionnaire","volume":"40","author":"Marquis","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"R14-8-20240829","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5056\/jnm.2012.18.1.94","article-title":"How to interpret a functional or motility test-colon transit study","volume":"18","author":"Kim","year":"2012","journal-title":"J Neurogastroenterol Motil"},{"key":"R15-8-20240829","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jep.2017.05.004","article-title":"A review of traditional uses, phytochemistry and pharmacology of Portulaca oleracea L","volume":"205","author":"Iranshahy","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"R16-8-20240829","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1111\/nmo.12103","article-title":"The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota","volume":"25","author":"Crouzet","year":"2013","journal-title":"Neurogastroenterol Motil"},{"key":"R17-8-20240829","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(17)30338-2","article-title":"Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial","volume":"3","author":"Johnsen","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"R18-8-20240829","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/ajg.2014.202","article-title":"Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: Systematic review and meta-analysis","volume":"109","author":"Ford","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"R19-8-20240829","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3746\/jfn.2004.9.4.306","article-title":"Antimicrobial effect of portulaca oleracea extracts on food-bone pathogens","volume":"9","author":"Bae","year":"2004","journal-title":"Prev Nutr Food Sci"}],"container-title":["Saudi Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjg.sjg_400_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:04:52Z","timestamp":1787756692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjg.sjg_400_21"}},"subtitle":["A randomized, double-blind, placebo-controlled trial"],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/sjg.sjg_400_21","relation":{},"ISSN":["1319-3767"],"issn-type":[{"value":"1319-3767","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}