{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:10Z","timestamp":1787761210285,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Crohn\u2019s disease (CD) is associated with malnutrition, an independent risk factor for surgical morbidity and mortality in more than 65% of patients, with a significant impact on disease outcomes. In this single-center retrospective cohort study, we aimed to investigate the impact of total parenteral nutrition (TPN) on the surgical outcomes of patients with CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included patients with CD who underwent abdominal surgery. We compared patients who received preoperative total parenteral nutrition (TPN group) to those who did not (non-TPN group). Prolonged oral intolerance, albumin level &lt;30 g\/L, and body mass index &lt;18.5 were the main indications for TPN. We evaluated postoperative surgical complications in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Between January 2010 and October 2018, 169 eligible patients underwent abdominal surgery. The TPN and non-TPN groups included 40 and 129 patients, respectively. The mean albumin level was significantly lower in the TPN group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.013). Laparoscopic surgery was performed in 76.9% of the patients, with a conversion rate of 11.6%. Infectious and non-infectious complications developed in 8.9% and 16% of patients, respectively. Surgical complications were comparable between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Despite oral intake intolerance and severe disease in the TPN group, the surgical complications were comparable between the groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjg.sjg_425_22","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T01:46:23Z","timestamp":1672364783000},"page":"158-163","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["The impact of preoperative total parenteral nutrition on the surgical complications of Crohn\u2019s disease: A retrospective cohort study"],"prefix":"10.4103","volume":"29","author":[{"given":"Thamer A.","family":"Bin Traiki","sequence":"first","affiliation":[{"name":"Department of Surgery, Colorectal Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-5489","authenticated-orcid":false,"given":"Sulaiman A.","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Surgery, Colorectal Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A.","family":"Aljomah","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monirah M.","family":"Alsalouli","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa S.","family":"Altawil","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Clinical Pharmacy Services, King Saud University Medical City, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha-Hamadien","family":"Abdulla","sequence":"additional","affiliation":[{"name":"Department of Surgery, Colorectal Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura S.","family":"Alhassan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Colorectal Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khayal A.","family":"Alkhayal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Colorectal Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"8646495","DOI":"10.1155\/2017\/8646495","article-title":"Nutrition and IBD:Malnutrition and\/or sarcopenia?A practical guide","volume":"2017","author":"Scaldaferri","year":"2017","journal-title":"Gastroenterol Res Pract"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/j.gastro.2013.07.041","article-title":"Risk of surgery for inflammatory bowel diseases has decreased over time:A systematic review and meta-analysis of population-based studies","volume":"145","author":"Frolkis","year":"2013","journal-title":"Gastroenterology"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.clnu.2019.11.002","article-title":"ESPEN practical guideline:Clinical Nutrition in inflammatory bowel disease","volume":"39","author":"Bischoff","year":"2020","journal-title":"Clin Nutr"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/ecco-jcc\/jjx102","article-title":"Prevalence of malnutrition and nutritional characteristics of patients with inflammatory bowel disease","volume":"11","author":"Casanova","year":"2017","journal-title":"J Crohns Colitis"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/nu9060562","article-title":"Preoperative nutritional conditioning of Crohn's patients-Systematic review of current evidence and practice","volume":"9","author":"Grass","year":"2017","journal-title":"Nutrients"},{"key":"R7-20240829","first-page":"1","article-title":"ECCO-ESCP consensus on surgery for Crohn's disease","volume":"12","author":"Bemelman","year":"2018","journal-title":"J Crohns Colitis"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/nu5020608","article-title":"Enteral and parenteral nutrition in the perioperative period:State of the art","volume":"5","author":"Abunnaja","year":"2013","journal-title":"Nutrients"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1097\/MD.0000000000000478","article-title":"Role of exclusive enteral nutrition in the preoperative optimization of patients with Crohn's disease following immunosuppressive therapy","volume":"94","author":"Li","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3390\/nu13051628","article-title":"Nutritional treatment in Crohn's disease","volume":"13","author":"Caio","year":"2021","journal-title":"Nutrients"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0002-9610(82)90144-1","article-title":"Preoperative total parenteral nutrition and surgical outcome in patients with inflammatory bowel disease","volume":"143","author":"Rombeau","year":"1982","journal-title":"Am J Surg"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/01.CCM.0000150960.36228.C0","article-title":"A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients","volume":"33","author":"Peter","year":"2005","journal-title":"Crit Care Med"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.clnu.2017.02.013","article-title":"ESPEN guideline:Clinical nutrition in surgery","volume":"36","author":"Weimann","year":"2017","journal-title":"Clin Nutr"},{"key":"R14-20240829","first-page":"102","article-title":"Total parenteral nutrition in the surgical patient:A meta-analysis","volume":"44","author":"Heyland","year":"2001","journal-title":"Can J Surg"},{"key":"R15-20240829","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/ajcn\/74.4.534","article-title":"Enteral compared with parenteral nutrition:A meta-analysis","volume":"74","author":"Braunschweig","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"R16-20240829","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bjid.2020.02.002","article-title":"Infectious complications associated with parenteral nutrition in intensive care unit and non-intensive care unit patients","volume":"24","author":"Comerlato","year":"2020","journal-title":"Braz J Infect Dis"},{"key":"R17-20240829","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/0148607116688437","article-title":"The relationship between parenteral nutrition and central line-associated bloodstream infections:2009-2014","volume":"42","author":"Fonseca","year":"2018","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"233","key":"R18-20240829","first-page":"235","article-title":"A prospective audit of total parenteral nutrition at a major teaching hospital","volume":"163","author":"Ioannides-Demos","year":"1995","journal-title":"Med J Aust"},{"key":"R19-20240829","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/0148607107031004284","article-title":"Risk factors of catheter-related bloodstream infections in parenteral nutrition catheterization","volume":"31","author":"Yilmaz","year":"2007","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"R20-20240829","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMoa1500964","article-title":"Intravascular complications of central venous catheterization by insertion site","volume":"373","author":"Parienti","year":"2015","journal-title":"N Engl J Med"},{"key":"R21-20240829","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jmii.2015.07.001","article-title":"Central line-associated bloodstream infections among critically-ill patients in the era of bundle care","volume":"50","author":"Lin","year":"2017","journal-title":"J Microbiol Immunol Infect"},{"key":"R22-20240829","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1177\/0148607114536580","article-title":"Utility of electronic medical records to assess the relationship between parenteral nutrition and central line-associated bloodstream infections in adult hospitalized patients","volume":"39","author":"Ippolito","year":"2015","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"R23-20240829","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ajg.2016.541","article-title":"Postoperative complications after ileocecal resection in Crohn's disease:A Prospective study from the REMIND Group","volume":"112","author":"Fumery","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"R24-20240829","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13304-020-00918-z","article-title":"Anastomosis configuration and technique following ileocaecal resection for Crohn's disease:A multicentre study","volume":"73","author":"Celentano","year":"2021","journal-title":"Updates Surg"},{"key":"R25-20240829","first-page":"648","article-title":"Preoperative total parenteral nutrition (TPN) in severe Crohn's disease","volume":"103","author":"Gouma","year":"1988","journal-title":"Surgery"},{"key":"R26-20240829","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/BF01540346","article-title":"Preoperative total parenteral nutrition for bowel resection in Crohn's disease","volume":"34","author":"Lashner","year":"1989","journal-title":"Dig Dis Sci"},{"key":"R27-20240829","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3109\/00365521.2011.648954","article-title":"Early postoperative complications in patients with Crohn's disease given and not given preoperative total parenteral nutrition","volume":"47","author":"Jacobson","year":"2012","journal-title":"Scand J Gastroenterol"},{"key":"R28-20240829","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/gastro\/goy033","article-title":"Pre-operative total parenteral nutrition improves post-operative outcomes in a subset of Crohn's disease patients undergoing major abdominal surgery","volume":"7","author":"Ayoub","year":"2019","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"R29-20240829","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1471-2482-13-14","article-title":"Laparoscopic surgery for Crohn's disease:A meta-analysis of perioperative complications and long term outcomes compared with open surgery","volume":"13","author":"Patel","year":"2013","journal-title":"BMC Surg"},{"key":"R30-20240829","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.4240\/wjgs.v13.i10.1190","article-title":"Laparoscopy for Crohn's disease:A comprehensive exploration of minimally invasive surgical techniques","volume":"13","author":"Wan","year":"2021","journal-title":"World J Gastrointest Surg"},{"key":"R31-20240829","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/ecco-jcc\/jjz187","article-title":"ECCO guidelines on therapeutics in Crohn's disease:Surgical treatment","volume":"14","author":"Adamina","year":"2020","journal-title":"J Crohns Colitis"},{"key":"R32-20240829","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/bjs.10595","article-title":"Short- and medium-term outcomes following primary ileocaecal resection for Crohn's disease in two specialist centres","volume":"104","author":"de Buck van Overstraeten","year":"2017","journal-title":"Br J Surg"}],"container-title":["Saudi Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjg.sjg_425_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:27:35Z","timestamp":1787758055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjg.sjg_425_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/sjg.sjg_425_22","relation":{},"ISSN":["1319-3767","1998-4049"],"issn-type":[{"value":"1319-3767","type":"print"},{"value":"1998-4049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,30]]},"assertion":[{"value":"2022-09-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}