{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:21:55Z","timestamp":1787772115293,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Several investigations suggested correlation between microscopic colitis (MC) and celiac disease (CD). This study aimed to examine this relationship using large-sized, population-based data with adequate control for confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study employed the National Inpatient Sample (NIS) database over 4 years (2016\u20132019). Patients with\/without MC in the presence\/absence of CD were identified through ICD-10 codes. Univariate and multi-variate analyses involving odds ratios (OR) and 95% confidence intervals (CI) were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall, 26,836,118 patients were analyzed. Of whom, 6,836 patients had MC (n = 179 with CD and n = 6,657 without CD). The mean hospital stay was not significantly different between both groups (5.42 \u00b1 5.44 days vs. 4.95 \u00b1 4.66 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.202). The univariate analysis revealed a significant association between MC and CD (OR = 22.69, 95% [19.55, 26.33],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). In the multi-variate analysis, which adjusted for potential confounders including age, race, hospital region, hospital teaching status, ZIP income, smoking status, alcohol overuse, hypertension, diabetes mellitus, lipidemia-related disorders, non-steroidal anti-inflammatory drug use, and selected auto-immune diseases, the association remained significant (OR = 15.71, 95% CI [13.52, 18.25],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Moreover, in patients with MC, the presence of CD emerged as a significant, independent variable of in-hospital mortality in univariate (OR = 2.87, 95% [1.14, 7.21],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025) and multi-variate (OR = 3.37, 95% CI [1.32, 8.60],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.011) analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study establishes a probable link between MC and CD, backed by both univariate and multi-variate analyses, while also identifying CD as an independent risk factor for increased mortality among MC patients. These findings need to be validated in real-world clinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjg.sjg_92_24","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T08:00:23Z","timestamp":1714982423000},"page":"319-323","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the association between microscopic colitis and celiac disease: A comprehensive analysis using the national in-patient data (2016\u20132019)"],"prefix":"10.4103","volume":"30","author":[{"given":"Abdullah","family":"Altawili","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed A.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhafer M.","family":"Alyami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman A.","family":"Alatawi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid S.","family":"Albalawi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muath A.","family":"Alghassab","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Fahad Specialist Hospital, Tabuk, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turki F. 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