{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:21Z","timestamp":1787775861533,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n \n Cronobacter sakazakii<\/jats:italic>\n is an opportunistic pathogen that mostly affects neonates, infants, and elderly people with weakened immune systems. No study has reported the frequency and antibiotic susceptibility patterns of\n C. sakazakii<\/jats:italic>\n from Oman, and thus this study was conducted to fill this gap in the literature.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This single-center retrospective study included\n C. sakazakii<\/jats:italic>\n isolates identified from different clinical samples of patients treated at Sohar Hospital, Oman, between January 2017 and December 2023. Bacterial identification and antibiotic susceptibility testing were done using the VITEK II automated microbiological system in accordance with the Clinical Laboratory Standards Institute (CLSI) guidelines.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 185\n C. sakazakii<\/jats:italic>\n isolates were included, most commonly from patients aged >60 years (42.7%) and <1 year (11.4%).\n C. sakazakii<\/jats:italic>\n strains had high susceptibility (>80%) to most of the tested antibiotics; however, for beta-lactam antibiotics, it ranged from 0% to 50%. Approximately 26.5% of the strains were multidrug resistant. Independent risk factors for increased frequency of multidrug-resistant strains were urinary catheterization (\n P<\/jats:italic>\n = 0.002), surgery (\n P<\/jats:italic>\n = 0.021), previous antibiotic therapy (\n P<\/jats:italic>\n = 0.047), and critical care unit admission (\n P<\/jats:italic>\n = 0.048). About one-fifth of the patients experienced life-threatening\n C. sakazakii<\/jats:italic>\n infections such as septicemia (15%) and pneumonia (4.7%). All deaths due to septicemia occurred in the >60 years (\n n<\/jats:italic>\n = 12) and <1 year (\n n<\/jats:italic>\n = 4) age groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n Cronobacter sakazakii<\/jats:italic>\n isolates from the North Batinah region of Oman were most frequently isolated from elderly and infant patients and had high antibiotic susceptibility; however, the significant resistance against beta-lactams suggests their low effectiveness. The high number of multidrug-resistant strains coupled with the independent risk factors suggests the need for following stricter antibiotic stewardship protocols and infection control practices.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_136_24","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T03:00:30Z","timestamp":1736737230000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Profile and Antibiotic Susceptibility Patterns of Cronobacter sakazakii in the Northern Region of Oman"],"prefix":"10.4103","volume":"13","author":[{"given":"Mohan Bilikallahalli","family":"Sannathimmappa","sequence":"first","affiliation":[{"name":"Department of Microbiology, College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Nambiar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama Mohammed Salih Adnan","family":"Al-Alawi","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouge Mohammad Salah","family":"Al-Fragi","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isra Mohammed Ali","family":"Al Mani","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Merza Ahmed Hasan Ahmed","family":"Madan","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences, National University of Science and Technology, Sohar Campus, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima","family":"Al-Maqbali","sequence":"additional","affiliation":[{"name":"Department of Pathology and Blood Bank, Sohar Hospital, Sohar, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Aravindakshan","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, 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