{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:23:10Z","timestamp":1787775790237,"version":"build-2784847793"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Several studies worldwide have studied the correlation between subclinical hypothyroidism (SCH), and metabolic syndrome (MetS), but have reported inconsistent findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the correlation between SCH and MetS in a population from Saudi Arabia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study was conducted at King Abdulaziz University Hospital and analyzed all thyroid function tests conducted between January 1, 2019, to December 31, 2021. A predesigned checklist was used to collect data about patients\u2019 characteristics such as age, gender, nationality, TSH, FT4 level, and MetS components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 41,519 thyroid function tests were conducted during the study period. From this, 1303 (3.1%) patients were found to have SCH, with the majority being females (74.4%). The prevalence did not differ according to gender but increased to 3.5% among those aged &gt;60 years. MetS components between mildly and markedly elevated TSH were significant for total cholesterol (P &lt; 0.001) and high-density lipoprotein cholesterol (P &lt; 0.05). Male patients with SCH were at a higher risk of developing diabetes (P &lt; 0.001) and hypertension (P &lt; 0.02), than female patients with SCH. After adjusting for age, in the multiple stepwise linear regression analysis, a significant association was found between TSH levels and ALT (odds ratio: 0.77) and SBP (odds ratio: 0.35).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study demonstrated that the prevalence of SCH is similar between both genders but increases with age. MetS components were abnormal in patients aged &gt;50 years and in males with SCH. SCH and MetS components were found to be correlated, and thus monitoring these variables in patients with SCH is advisable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_225_22","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T06:03:57Z","timestamp":1690610637000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study"],"prefix":"10.4103","volume":"11","author":[{"given":"Salhah Saleh","family":"Alsulami","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukhtiar","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atheer Hameed","family":"Albeladi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad Bandar","family":"Alyoubi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad Alhumaidi","family":"Alsubaie","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah Abdulsalam","family":"Albeladi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kholoud Alawi","family":"Ghamri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia"},{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer Mohammed Saeed","family":"Alraiqi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa Mobarak","family":"Alyoubi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam Aied","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"R1-20240909","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJM200107263450406","article-title":"Clinical practice. 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