{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:25Z","timestamp":1787071045726,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cleft lip and palate (CLP) can have an impact on the physical development of children; however, data from such studies is currently limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare growth parameters between children with non-syndromic CLP and healthy controls in Saudi Arabia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This case\u2013control retrospective cohort study included Saudi children with CLP and age- and gender-matched healthy children (1:1) who attended a tertiary care center in Riyadh, Saudi Arabia. Growth measurements (weight, length, and head circumference) were taken at the ages of 1 year and 2 years, and the Saudi Growth Chart was used as a reference data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 86 children in each group (\n                      <jats:italic toggle=\"yes\">N<\/jats:italic>\n                      = 172), with 31.4% females and 68.6% males. The mean current age was 3.2 \u00b1 1.7 years. Most patients had a unilateral CLP (96.5%). Multivariable analysis demonstrated that at the age of 1 year, compared with controls, patients with CLP had significantly lower weight (OR: 1.7,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026), weight standard deviation score (SDS) (OR: 0.4,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and head circumference SDS (OR: 0.8,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001); however, these did not remain significant at the age of 2 years. In the early repair (age &lt;1 year) and late repair (age \u22651 year) groups, 76.1% and 63.2% of the patients achieved catch-up growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study found that Saudi children with cleft lip and palate had significantly lower weight and head circumference compared with healthy children in the first year of life, but catch-up growth in the second year of life, largely following surgical repair, rendered these differences to be insignificant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_253_24","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:02:15Z","timestamp":1745280135000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Growth Parameters in Children with Non-syndromic Cleft Lip and Palate versus Healthy Controls: A Cohort Study from Riyadh, Saudi Arabia"],"prefix":"10.4103","volume":"13","author":[{"given":"Fadiah","family":"Alkhattabi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"},{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza","family":"Aljohar","sequence":"additional","affiliation":[{"name":"Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atheer","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munirah","family":"Alsalman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghad","family":"Alhuthil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Almuabyedh","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf","family":"Alsagheir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"},{"name":"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtisam","family":"Aljarba","sequence":"additional","affiliation":[{"name":"Department of Dentistry, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"R1-20250422","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jormas.2021.05.008","article-title":"Global prevalence of cleft palate, cleft lip and cleft palate and lip:A comprehensive systematic review and meta-analysis","volume":"123","author":"Salari","year":"2022","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"R2-20250422","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.15537\/smj.2015.9.11823","article-title":"Birth prevalence of non-syndromic orofacial clefts in Saudi Arabia and the effects of parental 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