{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:33:27Z","timestamp":1788608007362,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"\n Background:<\/jats:title>\n \n Candida<\/jats:italic>\n bloodstream infections cause significant excess morbidity and mortality in the health-care setting. There is limited evidence regarding\n Candida<\/jats:italic>\n species causing invasive infections in Saudi Arabia.\n <\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n \n To identify\n Candida<\/jats:italic>\n species causing bloodstream infection and determine the clinical outcome and factors associated with mortality in a tertiary center in Saudi Arabia.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This retrospective study included all cases of positive blood culture for\n Candida<\/jats:italic>\n in patients admitted to King Abdulaziz Medical City, a tertiary care center in Riyadh, Saudi Arabia, between January 1, 2013 and June 30, 2019.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 532 patients with candidemia were identified (male: 55.4%; mean age: 54 \u00b1 26.2 years). The most common\n Candida<\/jats:italic>\n species isolated was\n Candida albicans<\/jats:italic>\n (26.7%), followed by\n Candida glabrata<\/jats:italic>\n (22.7%),\n Candida parapsilosis<\/jats:italic>\n (22.2%), and\n Candida tropicalis<\/jats:italic>\n (18.4%). Non-\n albicans<\/jats:italic>\n candidemia was more common in patients with diabetes (76.7%;\n P<\/jats:italic>\n = 0.0560), neutropenia (89.8%;\n P<\/jats:italic>\n = 0.0062), recent exposure to fluconazole (85.7%;\n P<\/jats:italic>\n = 0.0394), and active chemotherapy (83.1%;\n P<\/jats:italic>\n = 0.0128). In non-\n albicans<\/jats:italic>\n , susceptibility to fluconazole varied from 95.9% with\n C. tropicalis<\/jats:italic>\n to 41.5% with\n C. parapsilosis<\/jats:italic>\n ; nonetheless, all species were highly susceptible to echinocandins. The overall 30- and 90-day mortality rates were 39.9% and 56.4%, respectively. The mortality rate was nonsignificantly higher with non-\n albicans<\/jats:italic>\n species at 30 days (41.2% vs. 35.9%;\n P<\/jats:italic>\n = 0.2634) and 90 days (58.2% vs. 51.4%;\n P<\/jats:italic>\n = 0.1620).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This study found a changing pattern in the\n Candida<\/jats:italic>\n species causing bloodstream infections and an epidemiological shift toward more non-\n albicans<\/jats:italic>\n Candida species in Saudi Arabia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_625_21","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T14:47:16Z","timestamp":1650034036000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Characteristics and Outcome of Candidemia"],"prefix":"10.4103","volume":"10","author":[{"given":"Hind","family":"Alhatmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Almansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Abanamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Abalkhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Alsaedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Alalwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameera","family":"AlJohani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar 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