{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:23:28Z","timestamp":1787757808711,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Xanthomatous meningioma is an extremely rare subtype of metaplastic meningiomas with few cases reported in the literature. Histopathologically, it is composed of oval-shaped cells that have central nuclei and cytoplasm with lipid-filled vacuoles, resembling macrophages. Here, the authors present a case of xanthomatous meningioma and discuss the hypotheses related to its origin and the differential diagnosis. A 40-year-old woman presented with an increased headache complaint over the past month. A computed tomography scan revealed a heterogeneous mass on the right parietal lobe, following which a right craniotomy was done. Microscopic examination showed neoplastic meningothelial cells with whorl formation and areas of xanthomatous changes. Both meningothelial and xanthomatous cells were positive with vimentin, progesterone, and epithelial membrane antigen. CD68 and lysozyme were expressed only in the xanthomatous component, and there was no expression with periodic acid-Schiff (PAS) stain and PAS\u2013diastase. As the diagnostic criteria of atypical meningioma were not observed, a diagnosis of xanthomatous meningioma, WHO grade I, was made. Owing to the characteristic xanthomatous changes, its differential diagnosis includes grade II clear cell meningioma, Rosai\u2013Dorfman disease, and hemangioblastoma. To avoid misidentifying these cells as macrophages, a high degree of awareness of this unique subtype of meningioma is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_705_20","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:46:45Z","timestamp":1641948405000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Rare Case of Xanthomatous Meningioma"],"prefix":"10.4103","volume":"10","author":[{"given":"Sultan Deniz","family":"Altindag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulya","family":"Cakalagaoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokay","family":"Karaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurullah","family":"Yuceer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R3-10-20240909","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00005072-199407000-00010","article-title":"Lipidized meningothelial tumor cells in \u201cxanthomatous\u201d meningioma express macrophage antigen","volume":"53","author":"Kepes","year":"1994","journal-title":"J Neuropathol Exp Neurol"},{"key":"R4-10-20240909","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s003810050109","article-title":"Xanthomatous posterior pyramid meningioma in a 2-year-old girl","volume":"13","author":"German\u00f2","year":"1997","journal-title":"Childs Nerv Syst"},{"key":"R5-10-20240909","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s003810050519","article-title":"Radiation-associated xanthomatous meningioma in a child","volume":"16","author":"Ijiri","year":"2000","journal-title":"Childs Nerv Syst"},{"key":"R6-10-20240909","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/00000478-200106000-00008","article-title":"Lipomatous meningioma: A clinicopathologic study of 18 cases with special reference to the issue of metaplasia","volume":"25","author":"Roncaroli","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R7-10-20240909","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1440-1789.2008.00865.x","article-title":"A case of metaplastic meningioma with extensive xanthomatous change","volume":"28","author":"Ikota","year":"2008","journal-title":"Neuropathology"},{"key":"R8-10-20240909","first-page":"2242","article-title":"Xanthomatous meningioma: A case report with review of the literature","volume":"6","author":"Ishida","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"R9-10-20240909","first-page":"112","article-title":"Clinicopathological analysis of metaplastic meningioma: Report of 15 cases in Huashan Hospital","volume":"25","author":"Tang","year":"2013","journal-title":"Chin J Cancer Res"},{"key":"R10-10-20240909","first-page":"445","article-title":"Xanthomatous meningioma \u2013 A rare case report","volume":"5","author":"Chougule","year":"2015","journal-title":"Int J Health Sci Res"},{"key":"R11-10-20240909","first-page":"141","article-title":"Xanthomatous meningioma: A case report","volume":"29","author":"Ersoz","year":"2019","journal-title":"Turk Neurosurg"},{"key":"R12-10-20240909","doi-asserted-by":"crossref","first-page":"66","DOI":"10.33762\/mjbu.2018.159462","article-title":"Xanthomatous meningioma; a rare histological variant","volume":"36","author":"Al-Diab","year":"2018","journal-title":"Med J Basrah Univ"},{"key":"R13-10-20240909","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/neup.12511","article-title":"Xanthomatous meningioma: A metaplastic or degenerative phenomenon?","volume":"38","author":"Wong","year":"2018","journal-title":"Neuropathology"},{"key":"R14-10-20240909","first-page":"125","article-title":"Xanthomatous changes in atypical and anaplastic meningiomas. 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