{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:59:01Z","timestamp":1785214741573,"version":"3.55.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Multiple sclerosis (MS) is a non-traumatic disability that affects the central nervous system and reduces quality of life (QoL). No study from Jordan has specifically assessed the QoL in patients with MS.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To evaluate QoL among Jordanian MS patients and examine its association with sociodemographic and medical characteristics.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This cross-sectional analytical study included adult Jordanian MS patients (aged \u226518 years) who attended the MS Unit at Albasheer Governmental Teaching Hospital, Amman, between December 2023 and July 2025. Data was collected through face-to-face interviews using the validated 26-item WHOQOL-BREF questionnaire.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 300 patients with MS were included (mean age: 35.3 \u00b1 11.1 years; female: 68.7%). The overall mean QoL score was 57.2 \u00b1 15.2, indicating generally low QoL. Physical and psychological domains had lower mean scores (49.7 \u00b1 18 and 57.8 \u00b1 18.4, respectively). In the univariate analysis, significant risk factors for poor QoL were parental consanguinity (OR: 1.88, 95% CI = 1.01\u20133.45) and smoking (OR: 1.74, 95% CI = 1.08\u20132.77). In the multivariable logistic regression analysis, factors independently associated with lower odds of higher QoL were smoking (OR = 0.454, 95% CI: 0.236\u20130.871;\n P<\/jats:italic>\n = 0.018), having one comorbidity (OR = 0.278, 95% CI: 0.108\u20130.714;\n P<\/jats:italic>\n = 0.008), and secondary progressive MS (OR = 0.260, 95% CI: 0.084\u20130.798;\n P<\/jats:italic>\n = 0.019).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The overall QoL of Jordanian multiple sclerosis patients is poor, particularly in the physical and psychological domains. Factors independently associated with lower odds of higher QoL were smoking, having one comorbidity, and secondary progressive multiple sclerosis, and thus interventions targeting these risk factors may improve the QoL.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_740_25","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:00:13Z","timestamp":1784664013000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life and Its Determinants among Jordanian Patients with Multiple Sclerosis: A Cross-sectional Analytical Study"],"prefix":"10.4103","volume":"14","author":[{"given":"Najah Essam","family":"Mahadin","sequence":"first","affiliation":[{"name":"Alkarak Health Directorate, Ministry of Health, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Sulaiman Odeh","family":"Alshobaki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Mohammed Mahmoud","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amro Osama Khalil","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obieda Husam","family":"Hussein","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour Amin","family":"Tarawneh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya Amin","family":"Tarawneh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University, Alkarak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashed Omar","family":"Alqaisi","sequence":"additional","affiliation":[{"name":"Ma\u2019an Health Directorate, Ministry of Health, Ma\u2019an, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Samer Abu","family":"Khashab","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Albasheer Hospital, Amman, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waqar Abdul-Qahar","family":"Al-Kubaisy","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Family Medicine, College of Medicine, Ashur University, Baghdad, 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