{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:35:27Z","timestamp":1786739727115,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Acute disseminated encephalomyelitis (ADEM) is an uncommon disease generally with a preceding history of infectious illness. Here, we report a rare case of ADEM following influenza A infection with transient detection of anti-myelin oligodendrocyte glycoprotein (MOG) antibody in a young male patient who presented with extensive demyelination of brain and spinal cord, likely the result of dysregulated immune response from previous influenza A infection. The patient presented to the emergency with urinary retention and progressive ascending weakness of lower limbs. Magnetic resonance imaging (MRI) of the brain and spinal cord showed multiple ill-defined hyperintensities, suggestive of demyelination. The clinical presentation, MRI findings, cerebrospinal fluid examination, negative anti-aquaporin-4 antibody and metabolic and other viral infectious screening supported the diagnosis of ADEM. The patient had transiently positive anti-MOG antibodies (for 3 months) and was treated with intravenous immunoglobulin followed by oral prednisolone for 3 months. There was a significant recovery in the upper limb weakness and brainstem function. This case highlights the association of anti-MOG antibody with ADEM following viral infections and the need for prolonged follow-up to differentiate between transient antibodies from relapsing MOG antibody disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjmms.sjmms_791_20","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T02:37:55Z","timestamp":1629513475000},"page":"271-275","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Transient Myelin Oligodendrocyte Glycoprotein Antibody-positive Acute Disseminated Encephalomyelitis Following Influenza A Infection"],"prefix":"10.4103","volume":"9","author":[{"given":"Prashant","family":"Nasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mortada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanchal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickrant","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240909","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1212\/WNL.0000000000002825","article-title":"Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome","volume":"87","author":"Pohl","year":"2016","journal-title":"Neurology"},{"key":"R2-11-20240909","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/B978-0-444-53488-0.00035-3","article-title":"Acute disseminated encephalomyelitis","volume":"123","author":"Javed","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"R4-11-20240909","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41582-018-0112-x","article-title":"Myelin oligodendrocyte glycoprotein antibodies in neurological disease","volume":"15","author":"Reindl","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"R5-11-20240909","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1007\/s00415-018-9122-2","article-title":"Neurological update: MOG antibody disease","volume":"266","author":"Wynford-Thomas","year":"2019","journal-title":"J Neurol"},{"key":"R6-11-20240909","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/biomedicines7020042","article-title":"Neuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes","volume":"7","author":"Lana-Peixoto","year":"2019","journal-title":"Biomedicines"},{"key":"R7-11-20240909","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1093\/brain\/awx276","article-title":"Clinical presentation and prognosis in MOG-antibody disease: A UK study","volume":"140","author":"Jurynczyk","year":"2017","journal-title":"Brain"},{"key":"R8-11-20240909","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fimmu.2017.00529","article-title":"Myelin oligodendrocyte glycoprotein: Deciphering a target in inflammatory demyelinating diseases","volume":"8","author":"Peschl","year":"2017","journal-title":"Front Immunol"},{"key":"R9-11-20240909","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-0039-1693152","article-title":"Diagnostic considerations in acute disseminated encephalomyelitis and the interface with MOG antibody","volume":"50","author":"Santoro","year":"2019","journal-title":"Neuropediatrics"},{"key":"R10-11-20240909","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7224\/1537-2073.2018-104","article-title":"Case report: Postvaccination anti-myelin oligodendrocyte glycoprotein neuromyelitis optica spectrum disorder: A case report and literature review of postvaccination demyelination","volume":"22","author":"Kumar","year":"2020","journal-title":"Int J MS Care"},{"key":"R11-11-20240909","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12883-014-0224-x","article-title":"Influenza-associated MOG antibody-positive longitudinally extensive transverse myelitis: A case report","volume":"14","author":"Amano","year":"2014","journal-title":"BMC Neurol"},{"key":"R12-11-20240909","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/jnnp-2017-316880","article-title":"Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination","volume":"89","author":"Ramanathan","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Saudi Journal of Medicine &amp; Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjmms.sjmms_791_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:31:55Z","timestamp":1786735915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjmms.sjmms_791_20"}},"subtitle":["A Rare Case"],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/sjmms.sjmms_791_20","relation":{},"ISSN":["1658-631X"],"issn-type":[{"value":"1658-631X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]}}}