{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:26:14Z","timestamp":1787765174936,"version":"build-2784847793"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A patient who had been diagnosed with infantile retinal dystrophy developed renal failure in his twenties, at which time the diagnosis was revised to Senior\u2013Loken syndrome. He was poorly compliant. At 36 years old, he experienced a sudden drop in visual acuity in the setting of cramping and fatigue and was found to be in uremic crisis. Six months after the event and its treatment, his vision failed to improved. Optic nerve pallor was out of proportion to the retinal dystrophy, and the presumed reason for his new visual loss was uremic optic neuropathy. The patient\u2019s younger sister also had been diagnosed with infantile retinal dystrophy, and metabolic screening confirmed subclinical renal dysfunction that was to be carefully followed going forward. Infantile retinal dystrophy can be associated with later systemic disease. Early detection of such disease can potentially decrease morbidity. Patients with retinal dystrophy can develop new visual loss from causes other than the retinopathy itself.<\/jats:p>","DOI":"10.4103\/sjopt.sjopt_140_23","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T14:01:35Z","timestamp":1704981695000},"page":"310-312","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Presumed uremic optic neuropathy in a patient with Senior\u2013Loken syndrome"],"prefix":"10.4103","volume":"37","author":[{"given":"Arif O.","family":"Khan","sequence":"first","affiliation":[{"name":"Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/gim.2015.127","article-title":"Expanding the clinical, allelic, and locus heterogeneity of retinal dystrophies","volume":"18","author":"Patel","year":"2016","journal-title":"Genet Med"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1097\/IAE.0000000000002675","article-title":"Phenotype-guided genetic testing of pediatric inherited retinal disease in the United Arab Emirates","volume":"40","author":"Khan","year":"2020","journal-title":"Retina"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-3-319-95046-4_34","article-title":"Ciliopathy:Senior-L\u00f8ken syndrome","volume":"1085","author":"Tsang","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000013344","article-title":"Uremic optic neuropathy. A uremic manifestation mandating dialysis","volume":"18","author":"Korzets","year":"1998","journal-title":"Am J Nephrol"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.semcdb.2020.07.013","article-title":"Primary cilia biogenesis and associated retinal ciliopathies","volume":"110","author":"Chen","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"E23","DOI":"10.1053\/ajkd.2001.22101","article-title":"Optic neuropathy in uremia:An interdisciplinary emergency","volume":"37","author":"Winkelmayer","year":"2001","journal-title":"Am J Kidney Dis"}],"container-title":["Saudi Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_140_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:02:31Z","timestamp":1787763751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_140_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/sjopt.sjopt_140_23","relation":{},"ISSN":["1319-4534","2542-6680"],"issn-type":[{"value":"1319-4534","type":"print"},{"value":"2542-6680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-06-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}