{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:44Z","timestamp":1792670864074,"version":"4.5.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>The purpose of the study was to study the outcome of indocyanine green enhanced transpupillary thermotherapy (ICG-E TTT) in the treatment of reactivation of retinoblastoma (RB) showing poor response to standard TTT after 6 cycles of systemic chemotherapy in pigmented Indian eyes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>After initial 6 cycles of standard-dose intravenous chemotherapy and focal consolidation with conventional TTT, ICG-E TTT was considered for reactivation of RB postchemotherapy when there was no response to 2 consecutive standard TTT or when there was minimal\/inadequate response to 4 or more standard TTT. Examination under general anesthesia was done after 4 weeks, and process was repeated if required. Treatment success was described as achieving a treatment-free follow-up and decreasing the need for further chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Ten eyes of 8 babies (7 with bilateral RB) received ICG enhanced TTT. In 8 out 10 eyes, good regression was noted following ICG E TTT, for a mean of 2 times using a mean power of 350 mW. Seven out of 8 babies did not need re-starting systemic chemotherapy for recurrence. The mean treatment-free follow-up was 6.4 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Using ICG-enhanced TTT, we achieved longer treatment-free follow-up and a decrease in the need for restarting systemic chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjopt.sjopt_206_23","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T17:00:14Z","timestamp":1764262814000},"page":"366-370","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Indocyanine green-enhanced transpupillary thermotherapy in treatment of retinoblastoma: Experience in Indian eyes"],"prefix":"10.4103","volume":"39","author":[{"given":"Abhishek","family":"Das","sequence":"first","affiliation":[{"name":"Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Maitra","sequence":"additional","affiliation":[{"name":"Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parag K.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ventatapathy","family":"Narendran","sequence":"additional","affiliation":[{"name":"Department of Pediatric Retina and Ocular Oncology, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"R1-20251201","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.3390\/cancers13246240","article-title":"Retinoblastoma survival following primary enucleation by AJCC staging","volume":"13","author":"Zhao","year":"2021","journal-title":"Cancers (Basel)"},{"key":"R2-20251201","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4103\/ijo.IJO_721_20","article-title":"Modern treatment of retinoblastoma: A 2020 review","volume":"68","author":"Ancona-Lezama","year":"2020","journal-title":"Indian J 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