{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:17Z","timestamp":1787772317742,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n PURPOSE:<\/jats:title>\n This study aimed to assess the efficacy and safety of sodium cromoglycate with fluorometholone in patients with allergic conjunctivitis.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n We conducted a single-arm phase IV open-label trial where fifty patients who received the eye drops were followed for 4 weeks. Treatment efficacy was assessed using the ocular itching score, conjunctival assessment score, total symptom and sign (TSS) score, and Visual Analog Scale (VAS).<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Patients who received sodium cromoglycate-fluorometholone eye drops experienced significant improvements in their ocular itching score (mean difference [MD]: 1.14,\n P<\/jats:italic>\n < 0.001) and conjunctival redness score (MD: 1.18,\n P<\/jats:italic>\n < 0.001). Statistically significant improvements in TSS and VAS were achieved in 78% of the patients reporting no conjunctivitis by the end of the study. The overall therapeutic response to the drug was as follows: 16% improved and 84% much improved. No serious adverse events were reported.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Sodium cromoglycate with fluorometholone eye drops achieved 100% therapeutic response among patients with allergic conjunctivitis. The eye drops improve the ocular itching, and conjunctival irritation without serious adverse events. This combination appears effective and tolerable for treatment of allergic conjunctivitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sjopt.sjopt_208_21","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:29:15Z","timestamp":1716186555000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of sodium cromoglycate-fluorometholone fixed combination eye drops in allergic conjunctivitis"],"prefix":"10.4103","volume":"36","author":[{"given":"Saeed","family":"Alwadani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-17-20240830","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1517\/14656566.2015.1040760","article-title":"Advances in pharmacotherapy for allergic conjunctivitis","volume":"16","author":"Abelson","year":"2015","journal-title":"Expert Opin Pharmacother"},{"key":"R2-17-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.iac.2007.12.011","article-title":"Ocular allergy overview","volume":"28","author":"Bielory","year":"2008","journal-title":"Immunol Allergy Clin North Am"},{"key":"R3-17-20240830","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/j.1365-2222.2009.03224.x","article-title":"Evaluation of desloratadine on conjunctival allergen challenge-induced ocular symptoms","volume":"39","author":"Torkildsen","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"R4-17-20240830","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2500\/aap.2013.34.3671","article-title":"Bepotastine Besilate Ophthalmic Solution 1.5% (Bepreve) Study Group. Efficacy of bepotastine besilate ophthalmic solution 1.5% for seasonal allergic conjunctivitis: A randomized, placebo-controlled, natural exposure, clinical trial","volume":"34","author":"Carr","year":"2013","journal-title":"Allergy Asthma Proc"},{"key":"R5-17-20240830","first-page":"35","article-title":"Treating the ocular component of allergic rhinoconjunctivitis and related eye disorders","volume":"9","author":"Bielory","year":"2007","journal-title":"MedGenMed"},{"key":"R6-17-20240830","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2165\/00003495-198631020-00003","article-title":"Ocular sodium cromoglycate. An overview of its therapeutic efficacy in allergic eye disease","volume":"31","author":"Sorkin","year":"1986","journal-title":"Drugs"},{"key":"R7-17-20240830","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF00160774","article-title":"Twice daily 4% Sodium Cromoglycate vs.2% Sodium Cromoglycate used four times daily in seasonal (grass pollen) allergic conjunctivitis","volume":"82","author":"Collum","year":"1992","journal-title":"Doc Ophthalmol"},{"key":"R8-17-20240830","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.intimp.2015.02.004","article-title":"Nasal sodium cromoglycate (Lomusol) modulates the early phase reaction of mild to moderate persistent allergic rhinitis in patients mono-sensitized to house dust mite: A preliminary study","volume":"26","author":"Lejeune","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"R9-17-20240830","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/jop.2008.0121","article-title":"Comparison of efficacy of bromfenac sodium 0.1% ophthalmic solution and fluorometholone 0.02% ophthalmic suspension for the treatment of allergic conjunctivitis","volume":"25","author":"Fujishima","year":"2009","journal-title":"J Ocul Pharmacol Ther"},{"key":"R10-17-20240830","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/ICO.0b013e318265684b","article-title":"Comparative evaluation of topical pranoprofen and fluorometholone in cases with chronic allergic conjunctivitis","volume":"32","author":"Li","year":"2013","journal-title":"Cornea"},{"key":"R11-17-20240830","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2105\/AJPH.94.3.361","article-title":"Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: The TREND statement","volume":"94","author":"Des Jarlais","year":"2004","journal-title":"Am J Public Health"},{"key":"R12-17-20240830","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/bmj.2.5402.177","article-title":"Human experimentation. code of ethics of the world medical association. declaration of helsinki","volume":"2","author":"Rickham","year":"1964","journal-title":"Br Med J"},{"key":"R13-17-20240830","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1755-3768.2011.02272.x","article-title":"Management of seasonal allergic conjunctivitis: Guide to therapy","volume":"90","author":"Bielory","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"R14-17-20240830","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s12325-012-0031-y","article-title":"Comparison of tacrolimus, fluorometholone, and saline in mild-to-moderate contact lens-induced papillary conjunctivitis","volume":"29","author":"Diao","year":"2012","journal-title":"Adv Ther"},{"key":"R15-17-20240830","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3109\/02713683.2013.827213","article-title":"Comparative evaluation of olopatadine 0.01% combined fluorometholone 0.1% treatment versus olopatadine 0.01% combined ketorolac 0.4% treatment in patients with acute seasonal allergic conjunctivitis","volume":"39","author":"Celik","year":"2014","journal-title":"Curr Eye Res"},{"key":"R16-17-20240830","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/ICL.0000000000000127","article-title":"Topical fluorometholone versus diclofenac sodium in cases with perennial allergic conjunctivitis","volume":"41","author":"Li","year":"2015","journal-title":"Eye Contact Lens"},{"key":"R17-17-20240830","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/112067219200200306","article-title":"Randomised double-masked trial of lodoxamide and sodium cromoglycate in allergic eye disease. A multicentre study","volume":"2","author":"Fahy","year":"1992","journal-title":"Eur J Ophthalmol"},{"key":"R18-17-20240830","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/bjo.81.1.23","article-title":"Effect of lodoxamide and disodium cromoglycate on tear eosinophil cationic protein in vernal keratoconjunctivitis","volume":"81","author":"Leonardi","year":"1997","journal-title":"Br J Ophthalmol"},{"key":"R19-17-20240830","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/eye.1998.67","article-title":"Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis","volume":"12","author":"Akman","year":"1998","journal-title":"Eye (Lond"},{"key":"R20-17-20240830","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40123-013-0020-5","article-title":"Intraocular pressure effects of common topical steroids for post-cataract inflammation: Are they all the same?","volume":"2","author":"Pleyer","year":"2013","journal-title":"Ophthalmol Ther"},{"key":"R21-17-20240830","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/112067211002000501","article-title":"Treatment of allergic conjunctivitis: Results of a 1-month, single-masked randomized study","volume":"20","author":"Figus","year":"2010","journal-title":"Eur J Ophthalmol"},{"key":"R22-17-20240830","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-2008-1035023","article-title":"Antazoline\/tetryzoline eyedrops in comparison with levocabastine eyedrops in acute allergic conjunctivitis","volume":"210","author":"Wertheimer","year":"1997","journal-title":"Klin Monbl Augenheilkd"}],"container-title":["Saudi Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_208_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:38:28Z","timestamp":1787769508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_208_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/sjopt.sjopt_208_21","relation":{},"ISSN":["1319-4534"],"issn-type":[{"value":"1319-4534","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}