{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:25:12Z","timestamp":1787775912526,"version":"build-2784847793"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>\n                    Beh\u00e7et\u2019s disease (BD) is a systemic disease characterized by the onset of oral aphthae, genital ulceration, skin lesions, and uveitis. Although it seems that the first description of this disease was made by Hippocrates in the 5\n                    <jats:sup>th<\/jats:sup>\n                    century BC, the Turkish dermatologist Hulusi Beh\u00e7et in 1937 proposed the association of oral and genital ulcers and uveitis as an expression of a distinct disease. This review aimed to critically examine the first descriptions by Hulusi Beh\u00e7et and compare the clinical ocular findings he reported between 1937 and 1940 with those observed in the current era. No significant changes have been observed over time regarding gender distribution, mean age at onset, bilaterality, and occurrence of posterior\/panuveitis, while the occurrence of hypopyon seems to decrease and that of anterior uveitis to increase. In Beh\u00e7et\u2019s works, it is possible to find a quite a detailed description of many of the common clinical features of this disease, based on the observation of a few cases, and without the aid of modern ancillary technologies. Finally, in recent reports, there is no adequate acknowledgment of Beh\u00e7et\u2019s first observations.\n                  <\/jats:p>","DOI":"10.4103\/sjopt.sjopt_216_24","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:00:11Z","timestamp":1739523611000},"page":"41-46","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Beh\u00e7et\u2019s disease: A review of the ophthalmologic findings reported in Beh\u00e7et\u2019s original descriptions"],"prefix":"10.4103","volume":"39","author":[{"given":"Massimo","family":"Accorinti","sequence":"first","affiliation":[{"name":"IRCCS Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Gilardi","sequence":"additional","affiliation":[{"name":"Eye Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Cecere","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"De Geronimo","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"R1-20250325","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3109\/09273948.2012.723112","article-title":"Epidemiology of Beh\u00e7et disease","volume":"20","author":"Khairallah","year":"2012","journal-title":"Ocul Immunol Inflamm"},{"key":"R2-20250325","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/archopht.1982.01030040433013","article-title":"Close association of HLA-Bw51 with Beh\u00e7et's disease","volume":"100","author":"Ohno","year":"1982","journal-title":"Arch Ophthalmol"},{"key":"R4-20250325","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1136\/bjo.40.6.355","article-title":"Description of Beh\u00e7et's syndrome in the Hippocratic third book of endemic diseases","volume":"40","author":"Feigenbaum","year":"1956","journal-title":"Br J Ophthalmol"},{"key":"R5-20250325","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4103\/0974-9233.58425","article-title":"Beh\u00e7et's uveitis","volume":"16","author":"Tugal-Tutkun","year":"2009","journal-title":"Middle East Afr J Ophthalmol"},{"key":"R6-20250325","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.survophthal.2005.04.009","article-title":"Current concepts in the etiology and treatment of Beh\u00e7et disease","volume":"50","author":"Evereklioglu","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"R8-20250325","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","article-title":"Clinical features of Chinese patients with Beh\u00e7et's disease","volume":"115","author":"Yang","year":"2008","journal-title":"Ophthalmology"},{"key":"R9-20250325","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10792-008-9273-8","article-title":"Spectrum of Beh\u00e7et's disease in Indian population","volume":"29","author":"Sachdev","year":"2009","journal-title":"Int Ophthalmol"},{"key":"R10-20250325","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0161-6420(03)00265-3","article-title":"Conjunctival ulcers in Beh\u00e7et's disease","volume":"110","author":"Zamir","year":"2003","journal-title":"Ophthalmology"},{"key":"R11-20250325","first-page":"751","article-title":"Isolated conjunctival ulcerations as the first sign of Beh\u00e7et's disease","volume":"16","author":"Merle","year":"2006","journal-title":"Eur J Ophthalmol"},{"key":"R12-20250325","first-page":"309","article-title":"Ocular manifestations of Behcet's disease in Indian patients","volume":"51","author":"Rohatgi","year":"2003","journal-title":"Indian J Ophthalmol"},{"key":"R13-20250325","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/bjo.86.2.140","article-title":"The incidence and pathology of conjunctival ulceration in Beh\u00e7et's syndrome","volume":"86","author":"Matsuo","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"R14-20250325","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.jfo.2020.03.026","article-title":"Posterior scleritis as a rare manifestation of Beh\u00e7et's disease","volume":"44","author":"Dehghani","year":"2021","journal-title":"J Fr Ophtalmol"},{"key":"R15-20250325","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/rheumatology\/kep232","article-title":"Peripheral ulcerative keratitis:An unusual primary ocular manifestation in Behcet's disease?","volume":"48","author":"Murphy","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"R16-20250325","doi-asserted-by":"crossref","first-page":"e16886","DOI":"10.1097\/MD.0000000000016886","article-title":"An unusual case of Behcet disease with posterior scleritis:A case report","volume":"98","author":"Yanagida","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"R17-20250325","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3349\/ymj.1999.40.3.294","article-title":"Neuro-Behcet's disease presenting with isolated unilateral lateral rectus muscle palsy","volume":"40","author":"Lew","year":"1999","journal-title":"Yonsei Med J"},{"key":"R18-20250325","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1442-9071.2006.01181.x","article-title":"Orbital inflammation associated with Beh\u00e7et's disease","volume":"34","author":"Hammami","year":"2006","journal-title":"Clin Exp Ophthalmol"},{"key":"R19-20250325","first-page":"1152","article-title":"Uber rezidivierende, aphthose, durch ein virus verursachte geschwure am mund, am auge und an den genitalien","volume":"105","author":"Beh\u00e7et","year":"1937","journal-title":"Dermatol Wochenschr, German."},{"key":"R20-20250325","first-page":"420","article-title":"Considerations sur le lesions aphteuses de la bouche et des parties genitales ainsi sur les manifestations oculaires d'origine probablement parasitarie et observations concernant leur foyer d'infection","volume":"45","author":"Beh\u00e7et","year":"1938","journal-title":"Bull Soc Fr Dermatol Syph"},{"key":"R21-20250325","first-page":"1037","article-title":"Kurze mitteilung uber fokalsepsis mit aphthosen erscheinungen an mund, genitalien und veranderungen an den augen, als wahrscheinliche folge einer durch virus bedingten allgemeininfektion","volume":"107","author":"Beh\u00e7et","year":"1938","journal-title":"Dermatol Wochenschr"},{"key":"R22-20250325","first-page":"674","article-title":"A propos d'une entite morbide due probablement a un virus special donnant lieu a une infection generalisee se manifestant par poussees recidivantes en trois regions principales et occasionnant en particulier des iritis repetes","volume":"46","author":"Beh\u00e7et","year":"1939","journal-title":"Bull Soc Fr Dermatol Syph"},{"key":"R23-20250325","first-page":"1222","article-title":"Einige bemerkungen zu meinen beobachtungen uber den trisymptomencomplex","volume":"13","author":"Beh\u00e7et","year":"1939","journal-title":"Med Welt"},{"key":"R24-20250325","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000253787","article-title":"Some observations on the clinical picture of the so-called triple symptoms complex","volume":"81","author":"Beh\u00e7et","year":"1940","journal-title":"Dermatologica"},{"key":"R25-20250325","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3349\/ymj.1997.38.6.327","article-title":"Life story of Dr. Hulusi Beh\u00e7et","volume":"38","author":"Saylan","year":"1997","journal-title":"Yonsei Med J"},{"key":"R26-20250325","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1523-1747.2002.01798.x","article-title":"A historical review of early descriptions of Adamantiades-Beh\u00e7et's disease","volume":"119","author":"Zouboulis","year":"2002","journal-title":"J Invest Dermatol"},{"key":"R27-20250325","first-page":"68","article-title":"L'iridectomia come intervento nell'ipopion recidivante","volume":"6","author":"Neuschuler","year":"1898","journal-title":"Ann Ottalmol"},{"key":"R28-20250325","first-page":"S2","article-title":"On relapsing, aphthous ulcers of the mouth, eye and genitalia caused by a virus. 1937","volume":"28","author":"Beh\u00e7et","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"R29-20250325","first-page":"271","article-title":"Sur un cas d'iritis a hypopion recidivant","volume":"168","author":"Adamantiades","year":"1931","journal-title":"Ann Ocul"},{"key":"R30-20250325","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1365-2133.1934.tb09758.x","article-title":"Recurrent buccal and vulvar ulcers with associated embolic phenomena in the skin and the eye","volume":"46","author":"Withwell","year":"1934","journal-title":"Br J Dermatol Syph"},{"key":"R31-20250325","first-page":"697","article-title":"Un nouveau syndrome:Iritis, ulcers aigus del la bouche et de la vulve. Sa parente avec l'iritis recidivante a hypopion","volume":"2","author":"Weekers","year":"1938","journal-title":"Arch Ophtalmol (Paris)"},{"key":"R32-20250325","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1136\/bjo.2007.123554","article-title":"Ocular features of Behcet's disease:An international collaborative study","volume":"91","author":"Kitaichi","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"R33-20250325","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s10067-010-1430-6","article-title":"Beh\u00e7et's disease:From East to West","volume":"29","author":"Davatchi","year":"2012","journal-title":"Clin Rheumatol"},{"key":"R34-20250325","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/09273948.2015.1094095","article-title":"Ocular Beh\u00e7et's disease:Changing patterns over time, complications and long-term visual prognosis","volume":"25","author":"Accorinti","year":"2017","journal-title":"Ocul Immunol Inflamm"},{"key":"R35-20250325","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ajo.2004.03.022","article-title":"Uveitis in Beh\u00e7et disease:An analysis of 880 patients","volume":"138","author":"Tugal-Tutkun","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"R38-20250325","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4103\/ojo.ojo_68_22","article-title":"Visual outcomes and factors predictive of visual loss in Behcet's disease in Sultan Qaboos university hospital, Oman","volume":"15","author":"Al Kharousi","year":"2022","journal-title":"Oman J Ophthalmol"},{"key":"R39-20250325","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.sjopt.2013.06.012","article-title":"Ocular manifestations of Beh\u00e7et's disease in Jordanian patients","volume":"27","author":"Abu-Ameerh","year":"2013","journal-title":"Saudi J Ophthalmol"},{"key":"R40-20250325","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1365-2133.2007.08116.x","article-title":"Clinical features and natural course of Beh\u00e7et's disease in 661 cases:A multicentre study","volume":"157","author":"Alpsoy","year":"2007","journal-title":"Br J Dermatol"},{"key":"R41-20250325","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/1756-185X.12691","article-title":"Adult Behcet's disease in Iran:Analysis of 6075 patients","volume":"19","author":"Davatchi","year":"2016","journal-title":"Int J Rheum Dis"},{"key":"R43-20250325","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10792-008-9273-8","article-title":"Spectrum of Beh\u00e7et's disease in the Indian population","volume":"29","author":"Sachdev","year":"2009","journal-title":"Int Ophthalmol"},{"key":"R44-20250325","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"R45-20250325","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.12107","article-title":"International criteria for Beh\u00e7et's disease (ICBD):A collaborative study of 27 countries on the sensitivity and specificity of the new criteria","volume":"28","author":"Davatchi","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R46-20250325","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bjophthalmol-2017-311334","article-title":"Neuro-ophthalmological manifestations of Beh\u00e7et's disease","volume":"103","author":"Alghamdi","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"R47-20250325","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4274\/tjo.galenos.2019.60308","article-title":"Beh\u00e7et's uveitis:Current diagnostic and therapeutic approach","volume":"50","author":"\u00c7akar \u00d6zdal","year":"2020","journal-title":"Turk J Ophthalmol"},{"key":"R48-20250325","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/112067210201200514","article-title":"Posterior segment involvement in ocular Beh\u00e7et's disease","volume":"12","author":"Ozdal","year":"2002","journal-title":"Eur J Ophthalmol"}],"container-title":["Saudi Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_216_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:45:19Z","timestamp":1787773519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_216_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/sjopt.sjopt_216_24","relation":{},"ISSN":["1319-4534","2542-6680"],"issn-type":[{"value":"1319-4534","type":"print"},{"value":"2542-6680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}