{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:26:59Z","timestamp":1786728419563,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"\n Acute dacryocystitis caused by\n Burkholderia Cepacia<\/jats:italic>\n and Sphingomonas Paucimobilis is uncommon. To the best of our knowledge, presence of mixed pathogens\n Burkholderia Cepacia<\/jats:italic>\n and Sphingomonas Paucimobilis causing acute dacryocystitis in immunocompetent patients never been described.\n Burkholderia Cepacia<\/jats:italic>\n and Sphingomonas Paucimobilis been reported only as a single microorganism causing other ocular infections in immunocompromised patients. Middle age, medically free female patient, presented to the emergency department at our hospital, with a history of nasolacrimal duct obstruct (NLDO) complaining of inferior preocular swelling associated with localized pain diagnosed as acute dacryocystitis. She was on oral Amoxicillin\/clavulanic acid, oral Nitroimidazole antimicrobial and topical Tobramycin from elsewhere. However, no improvement had been noticed. We kept the patient on the same medications and swaps taken for culture and sensitivity. Patient presented to the first follow-up appointment with no improvement on her status. Culture and sensitivity revealed 2 pathogens:\n Burkholderia Cepacia<\/jats:italic>\n and Sphingomonas Paucimobilis. We have changed the antibiotic to oral Trimethoprim\/ Sulfamethoxazole as it showed positive sensitivity to the pathogens based on the sensitivity chart. Second follow-up appointment patient\u2019s condition improved.\n <\/jats:p>","DOI":"10.4103\/sjopt.sjopt_29_23","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T03:31:12Z","timestamp":1719977472000},"page":"188-190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Acute dacryocystitis secondary to Burkholderia cepacia and Sphingomonas paucimobilis mixed infection: A novel case report"],"prefix":"10.4103","volume":"38","author":[{"given":"Nasser","family":"Alsobaie","sequence":"first","affiliation":[{"name":"Ophthalmology Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humoud","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Oculoplastics and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Madani","sequence":"additional","affiliation":[{"name":"Oculoplastics and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Sirajuddin","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan","family":"Althaqib","sequence":"additional","affiliation":[{"name":"Oculoplastics and Orbit Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12941-020-00407-6","article-title":"Clinico-microbiological profile of Burkholderia cepacia keratitis: A case series","volume":"20","author":"Ho","year":"2021","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jhin.2010.03.007","article-title":"Sphingomonas paucimobilis: A persistent Gram-negative nosocomial infectious organism","volume":"75","author":"Ryan","year":"2010","journal-title":"J Hosp Infect"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"787","DOI":"10.18240\/ijo.2021.05.24","article-title":"An unusual case report of Burkholderia cepacia endophthalmitis","volume":"14","author":"Chen","year":"2021","journal-title":"Int J Ophthalmol"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3341\/kjo.2008.22.1.63","article-title":"A case of postoperative Sphingomonas paucimobilis endophthalmitis after cataract extraction","volume":"22","author":"Seo","year":"2008","journal-title":"Korean J Ophthalmol"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.jcrs.2006.01.094","article-title":"Postoperative endophthalmitis caused by Sphingomonas paucimobilis","volume":"32","author":"Adams","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"R6-20260507","doi-asserted-by":"crossref","first-page":"e231642","DOI":"10.1136\/bcr-2019-231642","article-title":"Fulminant Sphingomonas paucimobilis keratitis: Case study and review of literature","volume":"12","author":"Agarwal","year":"2019","journal-title":"BMJ Case Rep"},{"key":"R7-20260507","first-page":"192864","article-title":"Posttraumatic Sphingomonas paucimobilis endophthalmitis","volume":"2015","author":"Droutsas","year":"2015","journal-title":"Case Rep Ophthalmol Med"},{"key":"R8-20260507","first-page":"115","article-title":"H. 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