{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:19:33Z","timestamp":1788178773944,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To investigate whether there is a difference in optical coherence tomography (OCT) parameters between patients who respond to treatment for amblyopia, patients who do not respond to treatment, and children who do not have amblyopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Children were divided into three groups: those with full visual acuity after amblyopia treatment, Group 1; those without complete visual acuity, Group 2; and those without amblyopia, Group 3. Macular thickness (MT), retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and choroidal vascular index (CVI) parameters were measured by OCT and compared among the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>A total of 110 eyes of 55 patients with amblyopia and 37 eyes of 37 healthy children were included in the study. There was no difference between the three groups in the mean central MT, RNFL, GCC, and CVI. A difference in macular inner temporal value was detected between Group 1 and 2 amblyopic eyes and the control group. There was a statistically significant difference between the 3 groups in the RNFL Superior and RNFL SN. However, there was no statistically significant difference between Group 1 and Group 2 in the 9-region MT or 12-region RNFL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Although there was a difference in the macular inner temporal, RNFL SUP, and RNFL SN parameters when the control group and children who received amblyopia treatment were compared, there was no difference in OCT parameters in treatment responder and nonresponder children after amblyopia treatment. OCT parameters do not provide additional information about the response to treatment for amblyopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/sjopt.sjopt_330_24","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T07:00:37Z","timestamp":1759215637000},"page":"286-292","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of optical coherence tomography findings according to treatment response in patients with amblyopia"],"prefix":"10.4103","volume":"40","author":[{"given":"Pinar","family":"Orenc","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Osmaniye State Hospital, Osmaniye, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliha E.","family":"Sonmezay","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Gungel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Istanbul Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"R1-20260831","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.4103\/ijo.IJO_11_19","article-title":"Simplified updates on the pathophysiology and recent developments in the treatment of amblyopia: A review","volume":"67","author":"Gopal","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00417-019-04254-w","article-title":"The treatment of amblyopia: Current practice and emerging trends","volume":"257","author":"Papageorgiou","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R3-20260831","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3109\/02713683.2013.805233","article-title":"Comparison of macular and retinal nerve fiber layer thickness in untreated and treated binocular amblyopia","volume":"38","author":"Chen","year":"2013","journal-title":"Curr Eye Res"},{"key":"R4-20260831","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1136\/bjophthalmol-2018-312172","article-title":"New advances in amblyopia therapy I: Binocular therapies and pharmacologic augmentation","volume":"102","author":"Kraus","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ophtha.2020.01.041","article-title":"Evaluating amblyopia treatment success using the American Academy of Ophthalmology IRIS50 measures","volume":"127","author":"Shoshany","year":"2020","journal-title":"Ophthalmology"},{"key":"R6-20260831","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/08820538.2019.1620810","article-title":"Imaging amblyopia: Insights from optical coherence tomography (OCT)","volume":"34","author":"Gaier","year":"2019","journal-title":"Semin Ophthalmol"},{"key":"R7-20260831","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1177\/1120672119834179","article-title":"Evaluation of choroidal thickness in amblyopia using optical coherence tomography","volume":"30","author":"Zha","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"R8-20260831","first-page":"1967621","article-title":"Macular thickness, foveal volume, and choroidal thickness in amblyopic eyes and their relationships to the treatment outcome","author":"Liu","year":"2018","journal-title":"J Ophthalmol 2018"},{"key":"R9-20260831","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1097\/IAE.0000000000001040","article-title":"Choroidal vascularity index in central serous chorioretinopathy","volume":"36","author":"Agrawal","year":"2016","journal-title":"Retina"},{"key":"R10-20260831","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10633-013-9422-x","article-title":"Structural and functional comparison of the persistent and resolved amblyopia","volume":"128","author":"Tugcu","year":"2014","journal-title":"Doc Ophthalmol"},{"key":"R11-20260831","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10792-016-0345-x","article-title":"Risk factors for treatment failure and recurrence of anisometropic amblyopia","volume":"37","author":"Kirandi","year":"2017","journal-title":"Int Ophthalmol"},{"key":"R12-20260831","doi-asserted-by":"crossref","first-page":"400","DOI":"10.5301\/ejo.5000583","article-title":"Meta-analysis of retinal changes in unilateral amblyopia using optical coherence tomography","volume":"25","author":"Li","year":"2015","journal-title":"Eur J Ophthalmol"},{"key":"R13-20260831","doi-asserted-by":"crossref","first-page":"e0174537","DOI":"10.1371\/journal.pone.0174537","article-title":"Thickness of retinal layers in the foveas of children with anisometropic amblyopia","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"R14-20260831","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4103\/ijo.IJO_1438_18","article-title":"Analysis of macular, foveal, and retinal nerve fiber layer thickness in children with unilateral anisometropic amblyopia and their changes following occlusion therapy","volume":"67","author":"Kavitha","year":"2019","journal-title":"Indian J Ophthalmol"},{"key":"R15-20260831","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s10792-015-0055-9","article-title":"Macular and retinal nerve fiber thickness in recovered and persistent amblyopia","volume":"35","author":"Yassin","year":"2015","journal-title":"Int Ophthalmol"},{"key":"R16-20260831","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10792-020-01624-w","article-title":"Macular capillary system and ganglion cell-layer complex of the amblyopic eye with optical cohorence tomography angiography and optical cohorence tomography","volume":"41","author":"Yilmaz Cinar","year":"2021","journal-title":"Int Ophthalmol"},{"key":"R17-20260831","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3109\/02713683.2013.779721","article-title":"The morpho-functional evaluation of retina in amblyopia","volume":"38","author":"Tugcu","year":"2013","journal-title":"Curr Eye Res"},{"key":"R18-20260831","first-page":"90","article-title":"Evaluation of peripapillary retinal nerve fiber layer, macula and ganglion cell thickness in amblyopia using spectral optical coherence tomography","volume":"6","author":"Firat","year":"2013","journal-title":"Int J Ophthalmol"},{"key":"R19-20260831","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.4103\/ijo.IJO_2875_21","article-title":"Retinal nerve fiber layer thickness in amblyopia","volume":"70","author":"Parikh","year":"2022","journal-title":"Indian J Ophthalmol"},{"key":"R20-20260831","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2147\/OPTH.S123273","article-title":"Measurement of peripapillary retinal nerve fiber layer thickness and macular thickness in anisometropia using spectral domain optical coherence tomography: A prospective study","volume":"11","author":"Singh","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"R21-20260831","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2147\/OPTH.S13145","article-title":"Retinal nerve fiber layer thickness in recovered and persistent amblyopia","volume":"4","author":"Miki","year":"2010","journal-title":"Clin Ophthalmol"},{"key":"R22-20260831","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.survophthal.2020.06.008","article-title":"Choroidal thickness and ocular growth in childhood","volume":"66","author":"Prousali","year":"2021","journal-title":"Surv Ophthalmol"},{"key":"R23-20260831","doi-asserted-by":"crossref","first-page":"21090","DOI":"10.1038\/srep21090","article-title":"Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci Rep"},{"key":"R24-20260831","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.survophthal.2018.11.002","article-title":"Choroidal imaging biomarkers","volume":"64","author":"Singh","year":"2019","journal-title":"Surv Ophthalmol"},{"key":"R25-20260831","doi-asserted-by":"crossref","first-page":"e0189735","DOI":"10.1371\/journal.pone.0189735","article-title":"Effect of optical correction on subfoveal choroidal thickness in children with anisohypermetropic amblyopia","volume":"12","author":"Nishi","year":"2017","journal-title":"PLoS One"},{"key":"R26-20260831","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1080\/02713683.2017.1315141","article-title":"Effect of amblyopia treatment on choroidal thickness in children with hyperopic anisometropic amblyopia","volume":"42","author":"Aslan Bayhan","year":"2017","journal-title":"Curr Eye Res"},{"key":"R27-20260831","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/cxo.12483","article-title":"Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?","volume":"100","author":"\u00d6ner","year":"2017","journal-title":"Clin Exp Optom"}],"container-title":["Saudi Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_330_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:02:17Z","timestamp":1788177737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_330_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/sjopt.sjopt_330_24","relation":{},"ISSN":["1319-4534","2542-6680"],"issn-type":[{"value":"1319-4534","type":"print"},{"value":"2542-6680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2024-12-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}