{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:10:11Z","timestamp":1791259811234,"version":"4.1.0"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Over the past decade, advances in genetic and genomic analyses, including genome-wide association studies, have provided substantial insights into the pathogenesis of Beh\u00e7et\u2019s disease (BD). These studies revealed potential pathogenic mechanisms such as the preparation and presentation of peptides by HLA Class I antigens, mainly HLA-B51, and endoplasmic reticulum aminopeptidase 1, recognition of presented peptides by CD8 T cells, dysregulated innate and adaptive immune response, including autoinflammation, activation of Th17 cells, natural killer cells, and M1-polarized macrophages, as well as disordered mucosal barrier defense. The genetic architecture of BD shares similarities with Crohn\u2019s disease, spondyloarthritis, as well as childhood-onset autoinflammatory diseases such as familial Mediterranean fever, A20 haploinsufficiency, periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome, or late-onset autoinflammatory diseases such as VEXAS syndrome and trisomy 8-related autoinflammatory diseases. This review summarizes the current understanding of the immunogenetic basis of BD, emphasizing how the interplay between changing environmental exposures and inherited or acquired genetic variants contributes to its heterogeneous and variable phenotypic expression.<\/jats:p>","DOI":"10.4103\/sjopt.sjopt_416_25","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T17:00:15Z","timestamp":1764262815000},"page":"323-328","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Immunogenetics of Beh\u00e7et\u2019s disease: Is there a link to recent phenotypic changes?"],"prefix":"10.4103","volume":"39","author":[{"given":"Yohei","family":"Kirino","sequence":"first","affiliation":[{"name":"Department of Stem Cell and Immune Regulation, Graduate School of Medicine, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Yokohama City University, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"R1-20251201","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra2305712","article-title":"Beh\u00e7et's syndrome","volume":"390","author":"Saadoun","year":"2024","journal-title":"N Engl J Med"},{"key":"R2-20251201","first-page":"2393","article-title":"Target organ associations in Turkish patients with Beh\u00e7et's disease: A cross sectional study by exploratory factor analysis","volume":"29","author":"Tunc","year":"2002","journal-title":"J Rheumatol"},{"key":"R3-20251201","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13075-020-02406-6","article-title":"Changes in the proportion of clinical clusters contribute to the phenotypic evolution of Beh\u00e7et's disease in Japan","volume":"23","author":"Soejima","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"R4-20251201","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s10067-024-06995-4","article-title":"Clinical phenotypes of adult-onset Beh\u00e7et's syndrome: A comprehensive cross-sectional study in China","volume":"43","author":"She","year":"2024","journal-title":"Clin Rheumatol"},{"key":"R5-20251201","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s10067-011-1694-5","article-title":"Diagnostic value of pathergy test in Behcet's disease according to the change of incidence over the time","volume":"30","author":"Davatchi","year":"2011","journal-title":"Clin Rheumatol"},{"key":"R6-20251201","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13075-016-1115-x","article-title":"Continuous evolution of clinical phenotype in 578 Japanese patients with Beh\u00e7et's disease: A retrospective observational study","volume":"18","author":"Kirino","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"R7-20251201","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/bjd.12661","article-title":"Changing clinical expression of Beh\u00e7et disease in Korea during three decades (1983-2012): Chronological analysis of 3674 hospital-based patients","volume":"170","author":"Kim","year":"2014","journal-title":"Br J Dermatol"},{"key":"R8-20251201","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3906\/sag-2003-147","article-title":"Decreasing incidence and severity of Beh\u00e7et's disease: A changing trend in epidemiological spectrum possibly associated with oral health","volume":"50","author":"Mumcu","year":"2020","journal-title":"Turk J Med Sci"},{"key":"R9-20251201","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s10384-020-00809-1","article-title":"Epidemiology of uveitis in Japan: A 2016 retrospective nationwide survey","volume":"65","author":"Sonoda","year":"2021","journal-title":"Jpn J Ophthalmol"},{"key":"R10-20251201","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1159\/000534316","article-title":"A comparison of adult and juvenile Behcet patients and a look at clinical trends: Retrospective data from a Turkish follow-up cohort study","volume":"239","author":"Boyvat","year":"2023","journal-title":"Dermatology"},{"key":"R11-20251201","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/s10165-006-0541-z","article-title":"HLA-B51 and cigarette smoking as risk factors for chronic progressive neurological manifestations in Beh\u00e7et's disease","volume":"17","author":"Aramaki","year":"2007","journal-title":"Mod Rheumatol"},{"key":"R12-20251201","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.autrev.2014.11.009","article-title":"Beh\u00e7et's syndrome patients exhibit specific microbiome signature","volume":"14","author":"Consolandi","year":"2015","journal-title":"Autoimmun Rev"},{"key":"R13-20251201","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/rheumatology\/keh236","article-title":"Oral health is impaired in Beh\u00e7et's disease and is associated with disease severity","volume":"43","author":"Mumcu","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"R14-20251201","doi-asserted-by":"crossref","first-page":"8867","DOI":"10.1073\/pnas.1406575111","article-title":"Beh\u00e7et disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity","volume":"111","author":"Ombrello","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R15-20251201","doi-asserted-by":"crossref","first-page":"1354969","DOI":"10.3389\/fimmu.2024.1354969","article-title":"Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Beh\u00e7et disease: A prospective registry study","volume":"15","author":"Hirahara","year":"2024","journal-title":"Front Immunol"},{"key":"R16-20251201","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0140-6736(73)93343-6","article-title":"Letter: HL-A5 and Beh\u00e7et's disease","volume":"2","author":"Ohno","year":"1973","journal-title":"Lancet"},{"key":"R17-20251201","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Beh\u00e7et's disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nat Genet"},{"key":"R18-20251201","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nrrheum.2015.147","article-title":"MHC-I-opathy-unified concept for spondyloarthritis and Beh\u00e7et disease","volume":"11","author":"McGonagle","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"R19-20251201","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","article-title":"Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh\u00e7et's disease","volume":"42","author":"Remmers","year":"2010","journal-title":"Nat Genet"},{"key":"R20-20251201","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/ng.3786","article-title":"Dense genotyping of immune-related loci implicates host responses to microbial exposure in Beh\u00e7et's disease susceptibility","volume":"49","author":"Takeuchi","year":"2017","journal-title":"Nat Genet"},{"key":"R21-20251201","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.1306352110","article-title":"Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Beh\u00e7et disease","volume":"110","author":"Kirino","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R22-20251201","doi-asserted-by":"crossref","first-page":"14405","DOI":"10.1073\/pnas.2002051117","article-title":"Common genetic susceptibility loci link PFAPA syndrome, Beh\u00e7et's disease, and recurrent aphthous stomatitis","volume":"117","author":"Manthiram","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R23-20251201","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/s41467-019-08923-6","article-title":"Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci","volume":"10","author":"Dudding","year":"2019","journal-title":"Nat Commun"},{"key":"R24-20251201","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/ard-2022-222852","article-title":"EULAR study group on 'MHC-I-opathy': Identifying disease-overarching mechanisms across disciplines and borders","volume":"82","author":"Kuiper","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"R25-20251201","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.0603095103","article-title":"Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance","volume":"103","author":"York","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R26-20251201","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nat Genet"},{"key":"R27-20251201","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Strange","year":"2010","journal-title":"Nat Genet"},{"key":"R28-20251201","first-page":"4333","article-title":"Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(birdshot) uveitis","volume":"27","author":"Kuiper","year":"2018","journal-title":"Hum Mol Genet"},{"key":"R29-20251201","doi-asserted-by":"crossref","first-page":"9680","DOI":"10.1074\/jbc.M117.789180","article-title":"The Beh\u00e7et's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing","volume":"292","author":"Guasp","year":"2017","journal-title":"J Biol Chem"},{"key":"R30-20251201","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/BOR.0000000000000189","article-title":"Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: Genetics","volume":"27","author":"Ombrello","year":"2015","journal-title":"Curr Opin Rheumatol"},{"key":"R31-20251201","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1136\/annrheumdis-2015-209059","article-title":"A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Beh\u00e7et's disease in HLA-B*51 carriers","volume":"75","author":"Takeuchi","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"R32-20251201","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1136\/ard-2022-222277","article-title":"Beh\u00e7et's disease risk-variant HLA-B51\/ERAP1-Hap10 alters human CD8 T cell immunity","volume":"81","author":"Cavers","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"R33-20251201","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/ard.2009.108571","article-title":"Genetics of Beh\u00e7et disease inside and outside the MHC","volume":"69","author":"Meguro","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"R34-20251201","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","article-title":"Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh\u00e7et's disease susceptibility loci","volume":"42","author":"Mizuki","year":"2010","journal-title":"Nat Genet"},{"key":"R35-20251201","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"R36-20251201","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13075-018-1613-0","article-title":"GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh\u00e7et's disease","volume":"20","author":"Nakano","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"R37-20251201","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa0907206","article-title":"Inflammatory bowel disease and mutations affecting the interleukin-10 receptor","volume":"361","author":"Glocker","year":"2009","journal-title":"N Engl J Med"},{"key":"R38-20251201","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1056\/NEJMoa1816594","article-title":"Trial of apremilast for oral ulcers in Beh\u00e7et's syndrome","volume":"381","author":"Hatemi","year":"2019","journal-title":"N Engl J Med"},{"key":"R39-20251201","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1093\/rheumatology\/kez204","article-title":"Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis","volume":"58","author":"Mavropoulos","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"R40-20251201","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/annrheumdis-2013-204475","article-title":"FUT2: Filling the gap between genes and environment in Beh\u00e7et's disease?","volume":"74","author":"Xavier","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"R41-20251201","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/rheumatology\/keg232R","article-title":"Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet's disease","volume":"42","author":"Karasneh","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"R42-20251201","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3389\/fimmu.2019.01067","article-title":"Beh\u00e7et's disease: An overview of etiopathogenesis","volume":"10","author":"Leccese","year":"2019","journal-title":"Front Immunol"},{"key":"R43-20251201","doi-asserted-by":"crossref","first-page":"e14852","DOI":"10.1111\/1756-185X.14852","article-title":"A case of Beh\u00e7et syndrome presenting with acute coronary syndrome","volume":"27","author":"Akkuzu","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"R44-20251201","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00281-015-0502-8","article-title":"Pathogenesis of Beh\u00e7et's disease: Autoinflammatory features and beyond","volume":"37","author":"G\u00fcl","year":"2015","journal-title":"Semin Immunopathol"},{"key":"R45-20251201","doi-asserted-by":"crossref","first-page":"109630","DOI":"10.1016\/j.clim.2023.109630","article-title":"Beh\u00e7et disease, familial Mediterranean fever and MEFV variations: More than just an association","volume":"251","author":"Seyahi","year":"2023","journal-title":"Clin Immunol"},{"key":"R46-20251201","first-page":"797","article-title":"The International FMF consortium","volume":"90","year":"1997","journal-title":"Cell"},{"key":"R47-20251201","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature13449","article-title":"Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome","volume":"513","author":"Xu","year":"2014","journal-title":"Nature"},{"key":"R48-20251201","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10875-021-01021-7","article-title":"Rapid flow cytometry-based assay for the functional classification of MEFV variants","volume":"41","author":"Honda","year":"2021","journal-title":"J Clin Immunol"},{"key":"R49-20251201","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/s41590-020-0705-6","article-title":"Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis","volume":"21","author":"Park","year":"2020","journal-title":"Nat Immunol"},{"key":"R50-20251201","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1002\/art.27683","article-title":"Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis","volume":"62","author":"Cosan","year":"2010","journal-title":"Arthritis Rheum"},{"key":"R51-20251201","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/MCG.0b013e3182597992","article-title":"Association of the MEFV gene variations with inflammatory bowel disease in Turkey","volume":"47","author":"Akyuz","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"R52-20251201","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/ng.3459","article-title":"Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat Genet"},{"key":"R53-20251201","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13075-019-1928-5","article-title":"Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Beh\u00e7et's disease","volume":"21","author":"Tsuchida","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"R54-20251201","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.20160724","article-title":"Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration","volume":"214","author":"Badran","year":"2017","journal-title":"J Exp Med"},{"key":"R55-20251201","doi-asserted-by":"crossref","first-page":"e17160","DOI":"10.1371\/journal.pone.0017160","article-title":"The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans","volume":"6","author":"Di","year":"2011","journal-title":"PLoS One"},{"key":"R56-20251201","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jaut.2018.09.002","article-title":"Efficacy of the anti-IL 17 secukinumab in refractory Beh\u00e7et's syndrome: A preliminary study","volume":"97","author":"Di Scala","year":"2019","journal-title":"J Autoimmun"},{"key":"R57-20251201","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2188\/jea.JE20190349","article-title":"Estimated prevalence of Cronkhite-Canada syndrome, chronic enteropathy associated with SLCO2A1 gene, and intestinal Beh\u00e7et's disease in Japan in 2017: A nationwide survey","volume":"31","author":"Oba","year":"2021","journal-title":"J Epidemiol"},{"key":"R58-20251201","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3349\/ymj.2021.62.2.99","article-title":"Incidence and prevalence of inflammatory bowel disease across Asia","volume":"62","author":"Park","year":"2021","journal-title":"Yonsei Med J"},{"key":"R59-20251201","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/rheumatology\/ker428","article-title":"Relationships of HLA-B51 or B5 genotype with Behcet's disease clinical characteristics: Systematic review and meta-analyses of observational studies","volume":"51","author":"Maldini","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"R60-20251201","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/14397595.2019.1649103","article-title":"The influence of HLA-B51 on clinical manifestations among Japanese patients with Beh\u00e7et's disease: A nationwide survey","volume":"30","author":"Mizuki","year":"2020","journal-title":"Mod Rheumatol"},{"key":"R61-20251201","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"key":"R62-20251201","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2021.07.004","article-title":"Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease","volume":"161","author":"Marnell","year":"2021","journal-title":"J Mol Cell Cardiol"},{"key":"R63-20251201","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13075-023-03014-w","article-title":"Interplay between chronic inflammation and clonal haematopoiesis of indeterminate potential in Beh\u00e7et's disease","volume":"25","author":"Park","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"R64-20251201","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1056\/NEJMoa2026834","article-title":"Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease","volume":"383","author":"Beck","year":"2020","journal-title":"N Engl J Med"},{"key":"R65-20251201","doi-asserted-by":"crossref","first-page":"108996","DOI":"10.1016\/j.clim.2022.108996","article-title":"Beh\u00e7et's disease with a somatic UBA1 variant: Expanding spectrum of autoinflammatory phenotypes of VEXAS syndrome","volume":"238","author":"Matsumoto","year":"2022","journal-title":"Clin Immunol"},{"key":"R66-20251201","first-page":"S145","article-title":"A reappraisal of the association between Beh\u00e7et's disease, myelodysplastic syndrome and the presence of trisomy 8: A systematic literature review","volume":"33","author":"Esatoglu","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"R67-20251201","first-page":"1718","article-title":"Distinct features of trisomy 8-associated autoinflammatory disease from Beh\u00e7et's disease: Case series and systematic review","volume":"43","author":"Ichikawa","year":"2025","journal-title":"Clin Exp Rheumatol"}],"container-title":["Saudi Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_416_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:23Z","timestamp":1787068043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/sjopt.sjopt_416_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/sjopt.sjopt_416_25","relation":{},"ISSN":["1319-4534","2542-6680"],"issn-type":[{"value":"1319-4534","type":"print"},{"value":"2542-6680","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-10-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}