{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:18:21Z","timestamp":1787854701008,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n PURPOSE:<\/jats:title>\n The purpose of the study is to compare the short-term outcomes of corneal collagen crosslinking (CXL) using the conventional (Dresden) protocol and an accelerated CXL (ACXL) protocol to stop keratoconus (KC) progression.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n A chart review was performed for all the patients with KC who underwent CXL in the last 7 years. Data were compared at baseline and at all follow-up examinations for uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BCVA), keratometry (K), central corneal thickness, and complications of CXL. Pre- and post-intervention values were compared for each group.\n P<\/jats:italic>\n < 0.05 was statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n After the treatment, there was a statistically greater improvement in UCVA in the conventional CXL (CCXL) group (49%) compared to the ACXL group (34%) (\n P<\/jats:italic>\n = 0.028). The improvement in BCVA was similar between the groups (\n P<\/jats:italic>\n = 0.060). Gain of two lines of UCVA and stability were comparable between groups (\n P<\/jats:italic>\n = 0.078 and\n P<\/jats:italic>\n = 0.060, respectively). The average flat K and steep K values fluctuated remarkably across different follow-up assessments in both the groups. At 3 months of follow-up, there was a statistically significantly faster return to baseline levels of flat and steep Ks in the CCXL group (\n P<\/jats:italic>\n = 0.028 and\n P<\/jats:italic>\n = 0.002, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n \n The findings of the current study confirm the efficacy and safety of accelerated high-fluence CXL compared to CCXL. Both protocols were effective in stabilizing KC at 9\n th<\/jats:sup>\n -month and the last follow-up visit. Larger prospective randomized controlled trials and longer follow-up are required to confirm our findings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/sjopt.sjopt_49_22","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:29:15Z","timestamp":1716186555000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Accelerated versus conventional corneal collagen 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