{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:28:52Z","timestamp":1786728532214,"version":"build-2736575974"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    is a versatile pathogen which can cause various mild to life-threatening infectious diseases. The evolution of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    resistance is notorious, from penicillin and oxacillin to vancomycin. Vancomycin, introduced in 1956, was once considered a most reliable antibiotic for methicillin-resistant\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    (MRSA); unfortunately, the first strain of\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    with decreased susceptibility to vancomycin emerged in 1996. Vancomycin has been approved in Taiwan since 1983, and the prevalence rates of heteroresistant vancomycin-intermediate\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    (hVISA) and vancomycin-intermediate\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    (VISA) in 2003 were 0.7% and 0.2%, respectively. However, a ten-fold increase of hVISA and VISA to 10% and 2.7%, respectively, in 2012\u20132013 could indicate a challenging clinical situation in Taiwan. The most commonly reported staphylococcal cassette chromosome\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    (SCC\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    ) types of hVISA and VISA are usually SCC\n                    <jats:italic toggle=\"yes\">mec<\/jats:italic>\n                    type III or II, typical nosocomial MRSA strains. Preventing the spread of resistant pathogens through infection control interventions and judicious antibiotic stewardship is a serious medical issue.\n                  <\/jats:p>","DOI":"10.4103\/tcmj.tcmj_145_17","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T08:43:15Z","timestamp":1525768995000},"page":"135-140","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility in Taiwan"],"prefix":"10.4103","volume":"30","author":[{"given":"Chien-Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Hsing","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Internal Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Hsiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hungkuang University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Mao","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"},{"name":"Division of Infectious Disease, Department of Internal Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"},{"name":"Department of Nursing, 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