{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:36:48Z","timestamp":1786653408951,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Adipocyte fatty acid-binding protein (A-FABP) has been implicated in atherosclerosis, and endothelial dysfunction is a critical contributor to cardiovascular outcomes in chronic kidney disease (CKD). This study evaluated links between serum A-FABP and endothelial function among patients with CKD who were not on dialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Fasting serum from 151 adults with CKD not on dialysis was analyzed for A-FABP using enzyme immunoassay. Endothelial function was measured noninvasively through digital thermal monitoring (DTM), yielding vascular reactivity index (VRI) scores categorized as poor (&lt;1.0), intermediate (1.0\u20131.99), or good (\u22652.0) vascular reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Vascular reactivity categorized by DTM-derived VRI was poor in 17.9% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 27), intermediate in 30.5% (n = 46), and good in 51.6% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 78). Poor reactivity correlated with older age (P = 0.013), higher blood urea nitrogen (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007), creatinine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009), urinary protein-to-creatinine ratio,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.010, higher serum A-FABP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and lower estimated glomerular filtration rate,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.007. In adjusted multivariable linear models, age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.044), log-transformed (log-glucose,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.045), and serum A-FABP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) were negatively associated with VRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher serum A-FABP independently correlated with reduced VRI, consistent with a potential modulatory role and supporting its use as a biomarker of endothelial dysfunction in nondialysis CKD patients.<\/jats:p>\n                  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