{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:33:21Z","timestamp":1786739601080,"version":"build-2736575974"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Objectives:<\/jats:title>\n Angiopoietin-like protein 3 (ANGPTL3) regulates triglyceride metabolism by reversibly inhibiting the lipoprotein lipase activity. Metabolic syndrome (MetS) is an independent risk factor for further cardiovascular disease. This study evaluated the relationship between the fasting serum ANGPTL3 levels and MetS in patients with coronary artery disease (CAD).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Fasting blood samples were obtained from 90 patients with CAD. Serum ANGPTL3 levels were measured using a commercial enzyme-linked immunosorbent assay kit. MetS and its components were defined using the diagnostic criteria of the International Diabetes Federation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Fifty-three patients (58.9%) had MetS. The hypertension (\n P<\/jats:italic>\n = 0.001), diabetes (\n P<\/jats:italic>\n < 0.001), body weight (\n P<\/jats:italic>\n = 0.027), body mass index (\n P<\/jats:italic>\n = 0.001), waist circumference (\n P<\/jats:italic>\n < 0.001), systolic blood pressure (\n P<\/jats:italic>\n = 0.001), fasting glucose (\n P<\/jats:italic>\n < 0.001), triglycerides (\n P<\/jats:italic>\n < 0.001), blood urea nitrogen (\n P<\/jats:italic>\n = 0.044), C-reactive protein (\n P<\/jats:italic>\n = 0.010), insulin (\n P<\/jats:italic>\n = 0.040), homeostasis model assessment of insulin resistance (\n P<\/jats:italic>\n = 0.002), and ANGPTL3 level (\n P<\/jats:italic>\n = 0.001) of CAD patients who had MetS were higher, and the high-density lipoprotein cholesterol (\n P<\/jats:italic>\n = 0.001) and estimated glomerular filtration rate (\n P<\/jats:italic>\n = 0.016) were lower. A binary logistic regression analysis of the significant variables also revealed that the ANGPTL3 level (odds ratio: 1.023, 95% confidence interval: 1.008\u20131.038,\n P<\/jats:italic>\n = 0.002) was an independent predictor of MetS in patients with CAD.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The results of our study indicated that the fasting ANGPTL3 level was positively associated with MetS among patients with CAD.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/tcmj.tcmj_49_21","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T08:07:42Z","timestamp":1628842062000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Positive correlation of serum angiopoietin-like protein 3 levels with metabolic syndrome in patients with coronary artery disease"],"prefix":"10.4103","volume":"34","author":[{"given":"Sy-Harn","family":"Lian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang-Gee","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240828","first-page":"e29","article-title":"Heart disease and stroke statistics \u2013 2015 update: A report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"R2-12-20240828","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s12041-015-0547-4","article-title":"Genetic epidemiology of coronary artery disease: An Asian Indian perspective","volume":"94","author":"Jayashree","year":"2015","journal-title":"J Genet"},{"key":"R3-12-20240828","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13098-017-0247-8","article-title":"Low serum adiponectin level is associated with metabolic syndrome and is an independent marker of peripheral arterial stiffness in hypertensive patients","volume":"9","author":"Chen","year":"2017","journal-title":"Diabetol Metab Syndr"},{"key":"R4-12-20240828","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/diabetes.52.5.1210","article-title":"Third National Health and Nutrition Examination Survey (NHANES III); National Cholesterol Education Program (NCEP). NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older","volume":"52","author":"Alexander","year":"2003","journal-title":"Diabetes"},{"key":"R5-12-20240828","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2337\/diacare.24.4.683","article-title":"Cardiovascular morbidity and mortality associated with the metabolic syndrome","volume":"24","author":"Isomaa","year":"2001","journal-title":"Diabetes Care"},{"key":"R6-12-20240828","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1463-1326.2004.00409.x","article-title":"The prevalence of the metabolic syndrome in Greece: The MetS-Greece Multicentre Study","volume":"7","author":"Athyros","year":"2005","journal-title":"Diabetes Obes Metab"},{"key":"R7-12-20240828","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","article-title":"Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections","volume":"21","author":"King","year":"1998","journal-title":"Diabetes Care"},{"key":"R8-12-20240828","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3109\/1061186X.2014.928715","article-title":"Angiopoietin-like proteins 3, 4 and 8: Regulating lipid metabolism and providing new hope for metabolic syndrome","volume":"22","author":"Li","year":"2014","journal-title":"J Drug Target"},{"key":"R10-12-20240828","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2017.02.030","article-title":"ANGPTL3 deficiency and protection against coronary artery disease","volume":"69","author":"Stitziel","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"R11-12-20240828","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MOL.0000000000000290","article-title":"Regulation of lipid metabolism by angiopoietin-like proteins","volume":"27","author":"Dijk","year":"2016","journal-title":"Curr Opin Lipidol"},{"key":"R12-12-20240828","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1194\/jlr.R018689","article-title":"GPIHBP1, an endothelial cell transporter for lipoprotein lipase","volume":"52","author":"Young","year":"2011","journal-title":"J Lipid Res"},{"key":"R13-12-20240828","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1194\/jlr.M300031-JLR200","article-title":"A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice","volume":"44","author":"Ando","year":"2003","journal-title":"J Lipid Res"},{"key":"R14-12-20240828","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1056\/NEJMoa1002926","article-title":"Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia","volume":"363","author":"Musunuru","year":"2010","journal-title":"N Engl J Med"},{"key":"R15-12-20240828","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/MOL.0b013e328333269e","article-title":"Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events","volume":"21","author":"Miida","year":"2010","journal-title":"Curr Opin Lipidol"},{"key":"R16-12-20240828","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2147\/TCRM.S150476","article-title":"Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease","volume":"14","author":"Fu","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"R17-12-20240828","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1253\/circj.CJ-09-0568","article-title":"Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease","volume":"74","author":"Hsu","year":"2010","journal-title":"Circ J"},{"key":"R18-12-20240828","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cca.2017.08.030","article-title":"High serum adipocyte fatty acid binding protein level as a potential biomarker of aortic arterial stiffness in hypertensive patients with metabolic syndrome","volume":"473","author":"Chen","year":"2017","journal-title":"Clin Chim Acta"},{"key":"R19-12-20240828","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.2147\/TCRM.S172231","article-title":"Association between hyperleptinemia and cardiovascular outcomes in patients with coronary artery disease","volume":"14","author":"Chen","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"R20-12-20240828","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome \u2013 A new world-wide definition. A Consensus Statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet Med"},{"key":"R21-12-20240828","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabet Med"},{"key":"R22-12-20240828","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1440-1797.2012.01607.x","article-title":"Impact of metabolic syndrome on the incidence of chronic kidney disease: A Chinese cohort study","volume":"17","author":"Yang","year":"2012","journal-title":"Nephrology (Carlton"},{"key":"R23-12-20240828","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.metabol.2016.11.003","article-title":"An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study","volume":"67","author":"Huh","year":"2017","journal-title":"Metabolism"},{"key":"R24-12-20240828","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.2215\/CJN.02180311","article-title":"Metabolic syndrome and kidney disease: A systematic review and meta-analysis","volume":"6","author":"Thomas","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"R25-12-20240828","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/jama.291.7.844","article-title":"Predictors of new-onset kidney disease in a community-based population","volume":"291","author":"Fox","year":"2004","journal-title":"JAMA"},{"key":"R26-12-20240828","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N Engl J Med"},{"key":"R27-12-20240828","doi-asserted-by":"crossref","first-page":"18J","DOI":"10.1016\/S0002-9149(03)00612-X","article-title":"Insulin resistance, inflammation, and the prediabetic state","volume":"92","author":"Haffner","year":"2003","journal-title":"Am J Cardiol"},{"key":"R28-12-20240828","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.dsx.2015.02.009","article-title":"Biological markers, lifestyles and metabolic syndrome in workers","volume":"9","author":"Kawada","year":"2015","journal-title":"Diabetes Metab Syndr"},{"key":"R29-12-20240828","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/met.2014.0163","article-title":"Synergistic interactions among metabolic syndrome components and homeostasis model assessment of insulin resistance in a middle-aged general population over time","volume":"13","author":"Bonora","year":"2015","journal-title":"Metab Syndr Relat Disord"},{"key":"R30-12-20240828","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00535-006-1790-5","article-title":"Visceral fat accumulation and insulin resistance are important factors in nonalcoholic fatty liver disease","volume":"41","author":"Eguchi","year":"2006","journal-title":"J Gastroenterol"},{"key":"R31-12-20240828","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/01.ATV.10.6.1067","article-title":"Secretion of plasminogen activator inhibitor-1 from cultured human umbilical vein endothelial cells is induced by very low density lipoprotein","volume":"10","author":"Stiko-Rahm","year":"1990","journal-title":"Arteriosclerosis"},{"key":"R32-12-20240828","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1161\/01.CIR.0000093278.75565.87","article-title":"Remnant lipoprotein-induced smooth muscle cell proliferation involves epidermal growth factor receptor transactivation","volume":"108","author":"Kawakami","year":"2003","journal-title":"Circulation"},{"key":"R33-12-20240828","first-page":"230","article-title":"Angiopoietin-like protein 3: Development, analytical characterization, and clinical testing of a new ELISA","volume":"26","author":"Stejskal","year":"2007","journal-title":"Gen Physiol Biophys"},{"key":"R34-12-20240828","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12020-015-0838-9","article-title":"The role of ANGPTL3 in controlling lipoprotein metabolism","volume":"52","author":"Tikka","year":"2016","journal-title":"Endocrine"},{"key":"R35-12-20240828","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng814","article-title":"Angptl3 regulates lipid metabolism in mice","volume":"30","author":"Koishi","year":"2002","journal-title":"Nat Genet"},{"key":"R36-12-20240828","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M203215200","article-title":"ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase","volume":"277","author":"Shimizugawa","year":"2002","journal-title":"J Biol Chem"},{"key":"R37-12-20240828","first-page":"70","article-title":"Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans","volume":"119","author":"Romeo","year":"2009","journal-title":"J Clin Invest"},{"key":"R38-12-20240828","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1612790","article-title":"genetic and pharmacologic inactivation of ANGPTL3 and cardiovascular disease","volume":"377","author":"Dewey","year":"2017","journal-title":"N Engl J Med"},{"key":"R39-12-20240828","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1194\/jlr.M200367-JLR200","article-title":"Regulation of the angiopoietin-like protein 3 gene by LXR","volume":"44","author":"Kaplan","year":"2003","journal-title":"J Lipid Res"},{"key":"R40-12-20240828","doi-asserted-by":"crossref","first-page":"21344","DOI":"10.1074\/jbc.M213202200","article-title":"Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor","volume":"278","author":"Inaba","year":"2003","journal-title":"J Biol Chem"},{"key":"R41-12-20240828","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1089\/met.2015.0053","article-title":"A larger body mass index is associated with increased atherogenic dyslipidemia, insulin resistance, and low-grade inflammation in individuals with metabolic syndrome","volume":"13","author":"Ebron","year":"2015","journal-title":"Metab Syndr Relat Disord"},{"key":"R42-12-20240828","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/ATVBAHA.113.301397","article-title":"Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids","volume":"33","author":"Robciuc","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R43-12-20240828","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbrc.2004.03.151","article-title":"ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states","volume":"317","author":"Inukai","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R44-12-20240828","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbrc.2004.08.024","article-title":"Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor","volume":"322","author":"Shimamura","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R45-12-20240828","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/MEG.0b013e32832b77ae","article-title":"Serum concentrations of human angiopoietin-like protein 3 in patients with nonalcoholic fatty liver disease: Association with insulin resistance","volume":"21","author":"Yilmaz","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R46-12-20240828","doi-asserted-by":"crossref","first-page":"E1299","DOI":"10.1210\/jc.2015-1254","article-title":"regulation of angiopoietin-like proteins (ANGPTLs) 3 and 8 by insulin","volume":"100","author":"Nidhina Haridas","year":"2015","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Tzu Chi Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tcmj.tcmj_49_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:30:25Z","timestamp":1786735825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tcmj.tcmj_49_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/tcmj.tcmj_49_21","relation":{},"ISSN":["1016-3190"],"issn-type":[{"value":"1016-3190","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}