{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:04:15Z","timestamp":1793271855896,"version":"4.5.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"\n OBJECTIVES:<\/jats:title>\n Effective sedation and analgesia during procedures not only provide relief of suffering but also frequently facilitate the successful and timely completion of the procedure. The aim of the study was to evaluate the efficacy of fentanyl and dexmedetomidine compared to fentanyl and midazolam in procedural sedation for tube thoracostomy in the emergency department (ED) in terms of analgesia and patient satisfaction with sedation during the procedure using Pain Numerical Rating Scale and a 7-point Likert-like verbal rating scale for comfort rating of sedation.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n A randomized control study was conducted in 64 subjects admitted to the ED. Tube thoracostomy was performed in patients after the decision for Intercostal drain (ICD) placement taken on radiographic and clinical assessment depending on their condition warranting it and after optimally stabilizing the patient in the ED. Of the total study participants that met the inclusion criteria, 32 participants randomly received dexmedetomidine and the other 32 received midazolam.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Pain rating scale means were 2.3 \u00b1 1.12 and 4.4 \u00b1 1.72, respectively (\n P<\/jats:italic>\n < 0.001), in dexmedetomidine and midazolam groups. With regard to adverse effects, a statistically significant difference was seen with dexmedetomidine causing hypotension (\n P<\/jats:italic>\n = 0.04) and midazolam causing desaturation (\n P<\/jats:italic>\n = 0.008). The results also suggested that midazolam achieved sedation levels quicker than dexmedetomidine and this finding was statistically significant (\n P<\/jats:italic>\n < 0.001). A statistically significant difference was observed (\n P<\/jats:italic>\n < 0.001) with regard to mean patient verbal ratings at recovery of sedation satisfaction between the two groups, 6 \u00b1 0.77 (dexmedetomidine group) versus 4.7 \u00b1 0.8 (midazolam group).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n When observed in terms of analgesia, anxiolysis, and better sedation, dexmedetomidine proved to be superior. Our study shows that this drug could be a better alternative to traditional benzodiazepines for procedural sedation in ED.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/tjem.tjem_175_24","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:02:01Z","timestamp":1744156921000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of fentanyl and dexmedetomidine versus fentanyl and midazolam in procedural sedation for tube thoracostomy in emergency department \u2013 A randomized control study"],"prefix":"10.4103","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-0387","authenticated-orcid":false,"given":"Sarat Chandra","family":"Uppaluri","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, AIG Hospitals, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-4059","authenticated-orcid":false,"given":"Anne Kiran","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0034-1422","authenticated-orcid":false,"given":"G. Suneel","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-5456","authenticated-orcid":false,"given":"Mohammed Ismail","family":"Nizami","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-9695","authenticated-orcid":false,"given":"Ashima","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Nizam\u2019s Institute of Medical Sciences, Hyderabad, Telangana, 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