{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:29:42Z","timestamp":1787761782038,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Mucormycosis is a progressive and life-threatening disease that has been increasingly reported in patients infected by coronavirus diseases 2019 (COVID-19). We describe a case of rhino-orbital mucormycosis with central nervous system involvement resulting in bilateral blindness and intracranial extension in a patient with uncontrolled diabetes mellitus (DM) and mild COVID-19 infection. A 35-year-old obese male, recently diagnosed with DM, presented to the emergency department suffering from dizziness, headache, speech difficulty, and facial weakness. His glycosylated hemoglobin was 10.4% and his reverse transcriptase\u2013polymerase chain reaction (PCR) test came positive for COVID-19. Ocular examination revealed left eye proptosis, ophthalmoplegia, and lid edema with no ocular movement. Imaging studies showed pansinusitis and periorbital and orbital cellulitis with intracranial involvement. Histopathology and biopsy examination confirmed mucormycosis. Medical management included glucose control and liposomal amphotericin B therapy. Septoplasty and functional endoscopic sinus surgery was performed as emergency procedures. The patient survived with bilateral blindness. In this case, we described the importance of considering mucormycosis in COVID-19 patients with uncontrolled diabetes, particularly those presenting with sinusitis, headache, and orbital edema symptoms. Despite intensive antifungal therapy and surgical intervention, it is a serious opportunistic fungal infection associated with long-term complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tjem.tjem_308_22","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T02:57:33Z","timestamp":1677639453000},"page":"62-65","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Rhino orbital cerebral mucormycosis"],"prefix":"10.4103","volume":"24","author":[{"given":"Hawra Ali Hussain","family":"Alsayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymen Ali","family":"Al-Qurain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyad Faoor","family":"Alrais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20240909","doi-asserted-by":"crossref","first-page":"e245343","DOI":"10.1136\/bcr-2021-245343","article-title":"Mucormycosis in a patient with COVID-19 with uncontrolled diabetes","volume":"14","author":"Shakir","year":"2021","journal-title":"BMJ Case Rep"},{"key":"R2-10-20240909","doi-asserted-by":"crossref","first-page":"e543","DOI":"10.1016\/S2666-5247(21)00237-8","article-title":"The emergence of COVID-19 associated mucormycosis: A review of cases from 18 countries","volume":"3","author":"Hoenigl","year":"2022","journal-title":"Lancet Microbe"},{"key":"R3-10-20240909","doi-asserted-by":"crossref","first-page":"815902","DOI":"10.3389\/fneur.2022.815902","article-title":"Rhino-orbital cerebral mucormycosis in a patient with diabetic ketoacidosis: A case report and literature review","volume":"13","author":"Dong","year":"2022","journal-title":"Front Neurol"},{"key":"R4-10-20240909","first-page":"251","article-title":"Rhino-orbital-cerebral mucormycosis in a young diabetic patient with COVID-19 in Ethiopia: A case report","volume":"15","author":"Alemayehu","year":"2022","journal-title":"Int Med Case Rep J"},{"key":"R5-10-20240909","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.bjoms.2021.06.013","article-title":"COVID-19 associated mucormycosis (CAM) in India:A formidable challenge","volume":"59","author":"Rao","year":"2021","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R6-10-20240909","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/1469-0691.12466","article-title":"Why is mucormycosis more difficult to cure than more common mycoses?","volume":"20","author":"Katragkou","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"R7-10-20240909","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.4103\/ijo.IJO_1565_21","article-title":"Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India \u2013Collaborative OPAI-IJO study on mucormycosis in COVID-19 (COSMIC), Report 1","volume":"69","author":"Sen","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R8-10-20240909","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/myc.13123","article-title":"Mucormycosis in the middle East and North Africa:Analysis of the FungiScope(\u00ae) registry and cases from the literature","volume":"63","author":"Stemler","year":"2020","journal-title":"Mycoses"},{"key":"R9-10-20240909","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41564-022-01172-2","article-title":"COVID-19-associated fungal infections","volume":"7","author":"Hoenigl","year":"2022","journal-title":"Nat Microbiol"},{"key":"R10-10-20240909","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12663-021-01604-2","article-title":"Current Understanding in the pathophysiology of SARS-CoV-2-Associated rhino-orbito-cerebral mucormycosis:A comprehensive review","volume":"20","author":"Jose","year":"2021","journal-title":"J Maxillofac Oral Surg"},{"key":"R11-10-20240909","doi-asserted-by":"crossref","first-page":"173854","DOI":"10.1016\/j.ejphar.2021.173854","article-title":"Dexamethasone:Therapeutic potential, risks, and future projection during COVID-19 pandemic","volume":"894","author":"Noreen","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"R12-10-20240909","doi-asserted-by":"crossref","first-page":"111643","DOI":"10.1016\/j.envres.2021.111643","article-title":"Mucormycosis: An opportunistic pathogen during COVID-19","volume":"201","author":"Mahalaxmi","year":"2021","journal-title":"Environ Res"},{"key":"R13-10-20240909","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1016\/S1473-3099(19)30312-3","article-title":"Global guideline for the diagnosis and management of mucormycosis: An initiative of the European confederation of medical mycology in cooperation with the mycoses study group education and research consortium","volume":"19","author":"Cornely","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"R14-10-20240909","first-page":"100057","article-title":"Mucormycosis in COVID-19 pandemic: Risk factors and linkages","volume":"2","author":"Kumar","year":"2021","journal-title":"Curr Res Microb Sci"},{"key":"R15-10-20240909","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/jamaophthalmol.2021.5201","article-title":"Cumulative mortality and factors associated with outcomes of mucormycosis after COVID-19 at a multispecialty tertiary care center in India","volume":"140","author":"Choksi","year":"2022","journal-title":"JAMA Ophthalmol"}],"container-title":["Turkish Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tjem.tjem_308_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:07:45Z","timestamp":1787760465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tjem.tjem_308_22"}},"subtitle":["A life-threatening complication of coronavirus diseases 2019 in an uncontrolled diabetic patient"],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/tjem.tjem_308_22","relation":{},"ISSN":["2452-2473"],"issn-type":[{"value":"2452-2473","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}