{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:22:09Z","timestamp":1787772129520,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n                    We report the feasibility of a combined approach of very low low tidal volume (VT) and mild therapeutic hypothermia (MTH) to decrease the ventilatory load in a severe COVID-19-related acute respiratory distress syndrome (ARDS) cohort. Inclusion criteria was patients \u226518-years-old, severe COVID-19-related ARDS, driving pressure \u2206P &gt;15 cmH\n                    <jats:sub>2<\/jats:sub>\n                    O despite low-VT strategy, and extracorporeal therapies not available. MTH was induced with a surface cooling device aiming at 34\u00b0C. MTH was maintained for 72 h, followed by rewarming of 1\u00b0C per day. Data were shown in median (interquartile range, 25%\u201375%). Mixed effects analysis and Dunnett\u2019s test were used for comparisons. Seven patients were reported. Ventilatory load decreased during the first 24 h, minute ventilation (VE) decreased from 173 (170\u2013192) to 152 (137\u2013170) mL\/kg\/min (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.007), and mechanical power (MP) decreased from 37 (31\u201340) to 29 (26\u201334) J\/min (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.03). At the end of the MTH period, the VT,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    , and plateau pressure remained consistently close to 3.9 mL\/kg predicted body weight, 12 and 26 cmH\n                    <jats:sub>2<\/jats:sub>\n                    O, respectively. A combined strategy of MTH and ultraprotective mechanical ventilation (MV) decreased VE and MP in severe COVID-19-related ARDS. The decreasing of ventilatory load may allow maintaining MV within safety thresholds.\n                  <\/jats:p>","DOI":"10.4103\/tjem.tjem_339_22","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T10:00:27Z","timestamp":1712311227000},"page":"117-121","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Ventilatory load reduction by combined mild hypothermia and ultraprotective mechanical ventilation strategy in severe COVID-19-related acute respiratory distress syndrome: A physiological study"],"prefix":"10.4103","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-1254","authenticated-orcid":false,"given":"Pablo","family":"Cruces","sequence":"first","affiliation":[{"name":"Unidad de Paciente Cr\u00edtico Pedi\u00e1trico, Hospital El Carmen de Maip\u00fa, Santiago, Chile"},{"name":"Centro de Investigaci\u00f3n de Medicina Veterinaria, Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7853-3603","authenticated-orcid":false,"given":"Diego","family":"Moreno","sequence":"additional","affiliation":[{"name":"Unidad de Paciente Cr\u00edtico Pedi\u00e1trico, Hospital El Carmen de Maip\u00fa, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-1508","authenticated-orcid":false,"given":"Sonia","family":"Reveco","sequence":"additional","affiliation":[{"name":"Unidad de Paciente Cr\u00edtico Pedi\u00e1trico, Hospital El Carmen de Maip\u00fa, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-2038","authenticated-orcid":false,"given":"Yenny","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Unidad de Paciente Cr\u00edtico Pedi\u00e1trico, Hospital El Carmen de Maip\u00fa, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-074X","authenticated-orcid":false,"given":"Franco","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Unidad de Paciente Cr\u00edtico Pedi\u00e1trico, Hospital El Carmen de Maip\u00fa, Santiago, Chile"},{"name":"Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"R1-20240909","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","author":"Brower","year":"2000","journal-title":"N Engl J 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