{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:20Z","timestamp":1787840540543,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This case report describes a 32-year-old male who underwent ketamine procedural sedation and experienced a generalized tonic\u2013clonic seizure. Despite its rapid onset and favorable tolerance profile, this case emphasizes the potential convulsive side effects of ketamine, which is commonly used for procedural sedation. While ketamine has shown promise in treating acute pain, refractory status epilepticus, and treatment-resistant depression and schizophrenia, it is associated with side effects such as hallucinations, visual disturbances, dizziness, nausea, and vomiting. The patient in this case received a carefully titrated dose of 40 mg of ketamine intravenously and underwent successful shoulder reduction while under sedation. However, within 60 s of receiving the ketamine, the patient experienced a 60-s seizure that was stopped with the administration of 5 mg of diazepam intravenously. The patient was hospitalized for further evaluation, including an electroencephalography (EEG) that showed no abnormalities. This case highlights the need for health-care professionals to be aware of the potential convulsive side effects of ketamine and to carefully monitor patients who receive ketamine sedation.<\/jats:p>","DOI":"10.4103\/tjem.tjem_67_24","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T17:00:08Z","timestamp":1727802008000},"page":"259-261","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Unexpected consequences: A case of ketamine-induced seizure in procedural sedation"],"prefix":"10.4103","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-6185","authenticated-orcid":false,"given":"Adem","family":"Az","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Haseki Training and Research Hospital, University of Health Sciences, Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-8777","authenticated-orcid":false,"given":"Yunus","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Mus State Hospital, Mus, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"R1-20241010","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and ketamine metabolite pharmacology:Insights into therapeutic mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol Rev"},{"key":"R2-20241010","first-page":"521","article-title":"Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists","volume":"43","author":"Cohen","year":"2018","journal-title":"Reg Anesth Pain Med"},{"key":"R3-20241010","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.ajem.2018.10.025","article-title":"Procedural sedation in children with autism spectrum disorders in the emergency department","volume":"37","author":"Brown","year":"2019","journal-title":"Am J Emerg Med"},{"key":"R5-20241010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0920-1211(00)00175-3","article-title":"Ketamine controls prolonged status epilepticus","volume":"42","author":"Borris","year":"2000","journal-title":"Epilepsy Res"},{"key":"R6-20241010","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41397-019-0120-2","article-title":"Ketamine in seizure management and future pharmacogenomic considerations","volume":"20","author":"Borsato","year":"2020","journal-title":"Pharmacogenomics J"},{"key":"R7-20241010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.7181\/acfs.2021.00094","article-title":"Ketamine-induced generalized convulsive seizure during procedural sedation","volume":"22","author":"Kim","year":"2021","journal-title":"Arch Craniofac Surg"},{"key":"R8-20241010","first-page":"433","article-title":"Pro-and anticonvulsant effects of anesthetics (part II)","volume":"70","author":"Modica","year":"1990","journal-title":"Anesth Analg"},{"key":"R9-20241010","doi-asserted-by":"crossref","first-page":"e24433","DOI":"10.1016\/j.heliyon.2024.e24433","article-title":"Ketamine:Pro or antiepileptic agent?A systematic review","volume":"10","author":"Shehata","year":"2024","journal-title":"Heliyon"}],"container-title":["Turkish Journal of Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tjem.tjem_67_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:44Z","timestamp":1787837084000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tjem.tjem_67_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/tjem.tjem_67_24","relation":{},"ISSN":["2452-2473","2452-2473"],"issn-type":[{"value":"2452-2473","type":"print"},{"value":"2452-2473","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}