{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:28:02Z","timestamp":1786739282781,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"\n \n \n We report a case of\n Alternaria chartarum<\/jats:italic>\n sclerokeratouveitis with an unfavorable response to treatment. To the best of our knowledge, there are no previous reports of this fungus invading the sclera. A 68-year-old diabetic farmer male patient presented with a 3-week history of pain and redness and a decrease in visual acuity occurring 5 days before admittance in the right eye. Examination revealed severe mixed hyperemia and a scleral calcified plaque with a surrounding area of ischemia and lysis. The cornea showed diffuse infiltrates, stromal edema, and hypopyon. Initial scrapings were negative, and empiric antibiotics were started. After a fungus was reported, topical and systemic antifungals were initiated, but there was no clinical response. The eye was enucleated. A slow-growing fungus\n A. chartarum<\/jats:italic>\n , resistant to voriconazole, was isolated. Fungal etiology must be kept in mind when dealing with infectious scleritis. Despite treatment, the outcome of this case was unfavorable due to the slow-growing nature of the fungus and this strain's resistance to voriconazole.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/tjo.tjo_17_19","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T05:07:46Z","timestamp":1587964066000},"page":"190-192","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Alternaria chartarum sclerokeratouveitis"],"prefix":"10.4103","volume":"11","author":[{"given":"Luz Elena","family":"Concha del R\u00edo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ramirez-Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Vanzzini-Zago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Arellanes-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20240830","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/ICO.0b013e318259c952","article-title":"Epidemiology and visual outcomes in patients with infectious scleritis","volume":"32","author":"Hodson","year":"2013","journal-title":"Cornea"},{"key":"R2-14-20240830","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/ICO.0000000000000174","article-title":"Infectious scleritis in Taiwan-a 10-year review in a tertiary-care hospital","volume":"33","author":"Ho","year":"2014","journal-title":"Cornea"},{"key":"R3-14-20240830","first-page":"2113","article-title":"Clinical characteristics and visual outcomes in infectious scleritis: A review","volume":"7","author":"Ramenaden","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"R4-14-20240830","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s12348-012-0062-1","article-title":"Early surgical debridement in the management of infectious scleritis after pterygium excision","volume":"2","author":"Tittler","year":"2012","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"R5-14-20240830","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/jac\/46.2.337","article-title":"In vitro antifungal susceptibility of Alternaria spp.and Ulocladium spp","volume":"46","author":"Pujol","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"R7-14-20240830","doi-asserted-by":"crossref","first-page":"536985","DOI":"10.1155\/2014\/536985","article-title":"Clinical characteristics of alternaria keratitis","volume":"2014","author":"Hsiao","year":"2014","journal-title":"J Ophthalmol"},{"key":"R8-14-20240830","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1128\/JCM.41.7.3358-3360.2003","article-title":"Rapid molecular diagnosis of posttraumatic keratitis and endophthalmitis caused by Alternaria infectoria","volume":"41","author":"Ferrer","year":"2003","journal-title":"J Clin Microbiol"},{"key":"R9-14-20240830","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4103\/0301-4738.121085","article-title":"Infectious scleritis: Clinical spectrum and management outcomes in India","volume":"61","author":"Pradhan","year":"2013","journal-title":"Indian J Ophthalmol"},{"key":"R10-14-20240830","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/09273948.2017.1372484","article-title":"Interventions and outcomes in patients with infectious Pseudomonas scleritis: A 10-year perspective","volume":"27","author":"Ahmad","year":"2019","journal-title":"Ocul Immunol Inflamm"}],"container-title":["Taiwan Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_17_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:27:34Z","timestamp":1786735654000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/tjo.tjo_17_19"}},"subtitle":["A new fungus cause"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/tjo.tjo_17_19","relation":{},"ISSN":["2211-5056"],"issn-type":[{"value":"2211-5056","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}