{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:50:03Z","timestamp":1792277403270,"version":"4.4.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This interventional case series demonstrates the usefulness of anterior segment optical coherence tomography (AS-OCT) in guiding early postoperative management following XEN45 Gel Stent implantation, in conjunction with intraocular pressure (IOP) readings and slit lamp findings. Three primary open-angle glaucoma patients undergoing XEN45 Gel Stent implantation were included. Two patients received early postoperative needling because the IOP was not low enough and AS-OCT revealed that the XEN stent orifice was trapped by the Tenon's capsule. Immediately after needling, the distal tip of the XEN stent was freed and connected to a cystic space with significant IOP reduction. The third patient suffered from abrupt bleb flattening on the 5\n                      <jats:sup>th<\/jats:sup>\n                      postoperative day following XEN stent implantation. AS-OCT revealed internal occlusion of the XEN stent with exudative material, which resolved spontaneously after intensifying topical steroids with improved bleb functioning 2 days later. AS-OCT provides in-depth microscopic evaluation of the XEN stent and its relationship with surrounding tissue. This information is helpful in identifying causes of impaired outflow, determining the timing, and effect of needling intervention in eyes with inadequate bleb functioning or IOP control, especially during the early postoperative period.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tjo.tjo_17_22","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T10:02:41Z","timestamp":1653472961000},"page":"495-498","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Optical coherence tomography-guided early postoperative management of XEN Gel implant"],"prefix":"10.4103","volume":"12","author":[{"given":"Yen-Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chieh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Jui-Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240830","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/ICU.0000000000000643","article-title":"Subconjunctival microinvasive glaucoma surgeries: An update on the Xen gel stent and the PreserFlo MicroShunt","volume":"31","author":"Do","year":"2020","journal-title":"Curr Opin Ophthalmol"},{"key":"R2-19-20240830","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.ophtha.2017.05.004","article-title":"Efficacy, safety, and risk factors for failure of standalone Ab interno gelatin microstent implantation versus standalone trabeculectomy","volume":"124","author":"Schlenker","year":"2017","journal-title":"Ophthalmology"},{"key":"R3-19-20240830","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1167\/iovs.15-16625","article-title":"Fluid dynamics of a novel micro-fistula implant for the surgical treatment of glaucoma","volume":"56","author":"Sheybani","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R4-19-20240830","first-page":"38","article-title":"Gel stent implantation \u2013 Recommendations for preoperative assessment, surgical technique, and postoperative management","volume":"11","author":"Vera","year":"2018","journal-title":"US Ophthalmic Rev"},{"key":"R5-19-20240830","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41433-018-0206-0","article-title":"Identifying the predictors of needling after XEN gel implant","volume":"33","author":"Midha","year":"2019","journal-title":"Eye (Lond"},{"key":"R6-19-20240830","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/JCMA.0000000000000430","article-title":"XEN45 gel stent implantation in eyes with primary open angle glaucoma: A study from a single hospital in Taiwan","volume":"84","author":"Chao","year":"2021","journal-title":"J Chin Med Assoc"},{"key":"R7-19-20240830","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.2147\/OPTH.S265695","article-title":"Surgical approaches for implanting xen gel stent without conjunctival dissection","volume":"14","author":"Vera","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"R8-19-20240830","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2147\/OPTH.S195457","article-title":"Recommendations for the management of elevated intraocular pressure due to bleb fibrosis after XEN gel stent implantation","volume":"13","author":"Vera","year":"2019","journal-title":"Clin 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Ophthalmol"},{"key":"R12-19-20240830","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.12688\/f1000research.12904.1","article-title":"Predictive value of early postoperative IOP and bleb morphology in Mitomycin-C augmented trabeculectomy","volume":"6","author":"Esfandiari","year":"2017","journal-title":"F1000Res"},{"key":"R13-19-20240830","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00417-019-04272-8","article-title":"Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN\u00ae stent implant","volume":"257","author":"Teus","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R14-19-20240830","doi-asserted-by":"crossref","first-page":"9364910","DOI":"10.1155\/2017\/9364910","article-title":"Evaluation of bleb morphology and reduction in IOP and glaucoma medication following implantation of a novel gel stent","volume":"2017","author":"Fea","year":"2017","journal-title":"J Ophthalmol"},{"key":"R15-19-20240830","first-page":"e231","article-title":"Longitudinal bleb morphology in anterior segment OCT after minimally invasive transscleral ab interno glaucoma gel microstent implantation","volume":"97","author":"Lenzhofer","year":"2019","journal-title":"Acta Ophthalmol"}],"container-title":["Taiwan Journal of 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