{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:58:04Z","timestamp":1792648684450,"version":"4.5.0"},"reference-count":102,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>A wide spectrum of phenotypic manifestations characterizes age-related macular degeneration (AMD). Drusen is considered the hallmark of AMD and is located underneath the retinal pigment epithelium (RPE). In contrast, subretinal drusenoid deposits (SDDs), also known as reticular pseudodrusens, are located in the subretinal space, on top of the RPE. SDDs are poorly detected by clinical examination and color fundus photography. Multimodal imaging is required for their proper diagnosis. SDDs are topographically and functionally related to rods. SDDs cause a deep impairment in retinal sensitivity and dark adaptation. SDDs are dynamic structures that may grow, fuse with each other, or regress over time. An intermediate step in some eyes is the development of an acquired vitelliform lesion. The presence of SDD confers an eye a high risk for the development of late AMD. SDD leads to macular neovascularization, particularly type 3, geographic atrophy, and outer retinal atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/tjo.tjo_18_22","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T10:02:41Z","timestamp":1653472961000},"page":"138-146","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Subretinal drusenoid deposits"],"prefix":"10.4103","volume":"12","author":[{"given":"Manuel","family":"Monge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihteh","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240830","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1167\/iovs.12-11073","article-title":"Association between geographic atrophy progression and reticular pseudodrusen in eyes with dry age-related macular degeneration","volume":"54","author":"Marsiglia","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R2-4-20240830","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/bjophthalmol-2014-306535","article-title":"Reticular drusen in eyes with high-risk characteristics for progression to late-stage age-related macular degeneration","volume":"99","author":"Steinberg","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"R3-4-20240830","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.survophthal.2018.05.005","article-title":"Subretinal drusenoid deposits AKA pseudodrusen","volume":"63","author":"Spaide","year":"2018","journal-title":"Surv Ophthalmol"},{"key":"R4-4-20240830","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/cxo.12842","article-title":"Reticular pseudodrusen: Current understanding","volume":"102","author":"Wightman","year":"2019","journal-title":"Clin Exp Optom"},{"key":"R5-4-20240830","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2147\/OPTH.S130165","article-title":"Spotlight on reticular pseudodrusen","volume":"11","author":"Rabiolo","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"R6-4-20240830","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.survophthal.2016.02.005","article-title":"Perspectives on reticular pseudodrusen in age-related macular degeneration","volume":"61","author":"Sivaprasad","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"R7-4-20240830","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/bjophthalmol-2014-305339","article-title":"Current knowledge on reticular pseudodrusen in age-related macular degeneration","volume":"99","author":"Alten","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"R8-4-20240830","first-page":"5","article-title":"A historical analysis of the quest for the origins of aging macula disorder, the tissues involved, and its terminology","volume":"8","author":"de Jong","year":"2016","journal-title":"Ophthalmol Eye Dis"},{"key":"R9-4-20240830","first-page":"409","article-title":"Drusen and disciform macular detachment and degeneration","volume":"70","author":"Gass","year":"1972","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R10-4-20240830","first-page":"511","article-title":"Macular drusen","volume":"13","author":"Mimoun","year":"1990","journal-title":"J Fr Ophtalmol"},{"key":"R11-4-20240830","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/IAE.0b013e3181ee5ce8","article-title":"Drusen characterization with multimodal imaging","volume":"30","author":"Spaide","year":"2010","journal-title":"Retina"},{"key":"R12-4-20240830","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0161-6420(91)32186-9","article-title":"The Wisconsin age-related maculopathy grading system","volume":"98","author":"Klein","year":"1991","journal-title":"Ophthalmology"},{"key":"R13-4-20240830","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00006982-199515030-00001","article-title":"Reticular pseudodrusen. 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